Clinical trials: Traumatic Injuries
Moderate Traumatic Brain Injury, Testican-1
Diagnostic Role of Serum Testican and Ubiquitin Levels in Patients With Head Trauma
We aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury.
- Conditions
- Moderate Traumatic Brain Injury, Testican-1, Ubiquitin
- Trial name
- NCT06537713
- Testing
- Testican-1
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Post Traumatic Stress Disorder, Anxiety
Level and Predictors of Trauma-symptoms Among Health Workers and Public Service Providers During the COVID-19 Outbreak
The aim of this study is to investigate the levels of trauma and mental symptoms (i.e., depression and anxiety) among health workers and public service providers during the strict social distancing government-initiated…
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT04374097
- Where
- Norway
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Concussion, Brain, Motor Vehicle Accident
Research Evaluating Sports ConcUssion Events - Rapid Assessment of Concussion and Evidence for Return
RESCUE-RACER is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. The RESCUE-RACER programme evaluates motorsports competitors at baseline (CArBON) and post-injury (CARS).
- Trial name
- RESCUE-RACER (NCT03844282)
- Testing
- Clinical assessment (SCAT5), ImPACT, CANTAB
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Brain Concussion
Effect of Soccer Head Gear to Reduce Concussions
This study will determine if protective soccer headgear reduces the incidence or severity of Sport Related Concussion injuries (SRCs) in US adolescent (high school) soccer players.
- Trial name
- Socheadgear (NCT02850926)
- Testing
- Soccer head gear
- Where
- United States
- Volunteers
- 3,050 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anger, Stress Disorders, Post-Traumatic
Remote Exercise for Learning Anger and Excitation Management
The immediate objective of this project was to demonstrate the feasibility of Remote Exercises for Learning Anger and Excitation Management (RELAX).
- Trial name
- RELAX (NCT02132793)
- Testing
- Anger Management Therapy, Anger Management Therapy & RELAX app
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Trauma, Brain
The Role of Hypoxia on Subconcussive Head Impacts
The purpose of this study is to examine the combined effects of hypoxia and a short bout of subconcussive head impacts on neurocognitive and ocular-motor function and plasma expression of brain-derived blood biomarkers.
- Trial name
- NCT04624152
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Mild Traumatic Brain Injury, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury
This feasibility study is being conducted to determine potential associations between a broad range of clinical neurological symptoms and magnetic resonance images (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- TBI (NCT02070588)
- Testing
- MRI
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Traumatic Brain Injury, Injury of Body Region
Neuroimaging & Plasma Markers for Predicting Outcomes After Mild Traumatic Brain Injury
This exploratory study aims to identify the most promising biomarkers that alone or in combination might predict development of mood disorders [i.e., major depression (MD], cognitive disorders [i.e., executive function deficits…
- Trial name
- NCT02891941
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Concussion
Recent Experiences With Concussions
College athletes will be recruited to complete a voluntary online survey that will take approximately 10 minutes. In this survey, they will answer a series of questions related to the concussion symptoms they have experienced in…
- Trial name
- NCT02626650
- Testing
- Symptom elicitiation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
PTSD
Psychological First Aid (PFA): RCT Adults Non-intentional Trauma Emergency Room
Psychological First Aid (PFA) is currently the most recommended early intervention for people affected by recent traumatic events, especially in the aftermath of natural disasters.
- Trial name
- PFA (NCT02608086)
- Testing
- Psychoeducation, Psychological First Aid
- Where
- 5 sites in Chile
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Post Traumatic Stress Disorder, Depression
Impact of COVID-19 Pandemic in Perinatal Mental Health (RISEUP-PPD-COVID-19)
Introduction: Coronavirus disease 2019 (COVID-19) is a new pathology, declared a public health emergency by the World Health Organization, which can have negative consequences for pregnant women and their newborns.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety, Psychological Distress
- Trial name
- NCT04595123
- Where
- 13 sites in Albania, Brazil and 11 more
- Volunteers
- 7,642 people, healthy volunteers welcome
- Sponsor
- University of Minho
Child Health, Bypass Graft Occlusion
Long-term Outcome in Pediatric Surgical Bypass Grafting After Traumatic Injury and Tumor Resection
Introduction: Vascular bypass surgery in children differs significantly from adults. It is a rarely performed procedure in the setting of trauma and tumor surgery to facilitate limb salvage.
- Trial name
- NCT04455373
- Testing
- pediatric vascular bypass grafting
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Post Traumatic Stress Disorder, Trauma, Psychological
Women's Responses to a Mindfulness-Based Body Scan: A Pilot Study
PTSD develops after trauma and is marked by intrusive memories, avoidance of reminders, negative changes in mood and cognitive processes, and dysregulated physical and emotional stress reactivity.
- Trial name
- NCT05137769
- Testing
- Body Scan
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Brain Concussion, Brain Injuries
An Evaluation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion
The HeadSense (HS) HS-1000 device, a new non-invasive brain monitor is expected to safely and accurately monitor concussed patients with minimal discomfort, potentially providing a new modality for concussion measurement.
- Trial name
- NCT02699346
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Concussion (Diagnosis), Sport-related Concussion
Longitudinal Monitoring of Head Impacts in Elite Junior Ice Hockey
This study aims to better understand how head impacts during ice hockey affect the brain and body, especially in young athletes.
- Conditions
- Concussion (Diagnosis), Sport-related Concussion, Hockey Player
- Trial name
- DRAK-CARE (NCT07341880)
- Testing
- Head impact monitoring, Heart rate variability monitoring, Dual-task cognitive and motor assessment
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Stress Disorders, Post-Traumatic
Probabilistic Risk Modeling for Disorder Post Traumatic Stress (PTSD) After the Attacks in Paris In November 2015
The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most…
- Trial name
- BV13 (NCT02853513)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Posttraumatic Stress Disorder
Relaxation Response Training for PTSD Prevention in US Military Personnel
The purposes of this study are to evaluate the acceptability and utility of a mind-body intervention on a convenience sample of Soldiers (n=120) who have screened positive through RESPECT-MIL for symptoms that may lead to…
- Trial name
- RR (NCT01725854)
- Testing
- Relaxation Response training
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- William Beaumont Army Medical Center
Depression, Anxiety
Enhancing the Effectiveness of Cognitive Behavioral Therapy Using Non-invasive Brain Stimulation
The purpose of the proposed study is to examine if a repeated treatment of High Definition Transcranial Direct Current Stimulation (HD-tDCS) can increase the functional connectivity between the left ventrolateral prefrontal…
- Conditions
- Depression, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT05555056
- Testing
- MxN-9 HD-tES Stimulator (Soterix Inc.)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
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