Clinical trials: Traumatic Injuries
Concussion, Brain
Comparison of Concussion Education Programs
Importance: Concussion underreporting leads to delays in diagnosis and treatment, resulting in prolonged recovery. Athletes' report of concussion symptoms is therefore an important component of risk reduction.
- Trial name
- NCT04492696
- Testing
- Education
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Stanford University
Concussion, Brain, Sports Injury
Wearables in Rugby Union: A Protocol for Multimodal Digital Sports-related Concussion Assessment
The investigators aim to use a repeated measures observational study utilising a battery of multimodal assessment tools (symptom, cognitive, visual, motor).
- Trial name
- NCT04938570
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Parent-Child Relations, PTSD
CAVEAT: An Open-Trial Feasibility Study
This is an open-clinical trial to study the feasibility of a brief manualized psychotherapy for mothers interpersonal violence-related posttraumatic stress disorder (PTSD) and their very young children ages 1-3 years, entitled…
- Conditions
- Parent-Child Relations, PTSD, Dissociation
- Trial name
- CAVEAT-OT (NCT06552832)
- Testing
- CAVEAT
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Aquired Brain Injury, Traumatic Brain Injuries
Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices
Background: Cardiovascular and neurological conditions are major causes of disability worldwide. Early, intensive rehabilitation is essential but often challenging to access in current healthcare systems.
- Conditions
- Aquired Brain Injury, Traumatic Brain Injuries, Stroke, Cardiovascular Diseases
- Trial name
- NCT06867081
- Testing
- The intervention will be the BRILLIANT Platform, an online platform which provides five Modules aimed at increasing coordination of care and direct rehabilitation time
- Where
- 2 sites in Canada
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Posttraumatic Stress Disorder
Clinical Trial to Preliminarily Assess the Safety and Feasibility of SAT-014, a Software for Alleviating Symptoms of Trauma and Stress-related Disorders
Failure to adapt to stress leads to functional impairments in various areas, including social, occupational, educational, and other significant domains, necessitating therapeutic intervention.
- Trial name
- NCT06439407
- Testing
- SAT-014(Software as Medical Device)
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Alpha Therapeutics, Inc.
Traumatic Brain Injury
Combinated Cues and Virtual Spatial Navigation
Many patients suffer from a topographical disorientation after a traumatic brain injury. Virtual Reality settings allow us to develop navigational cues, in order to rehabilitate patients or to help them in daily life.
- Trial name
- CombiVirtual (NCT03534128)
- Testing
- Evaluation of the effect of cues on virtual spatial navigation using a virtual district
- Where
- 4 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Ressources Francilien du Traumatisme Crânien
Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19
Digital Interventions to Understand and Mitigate Stress Response
Stress, anxiety, distress, and burnout are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Conditions
- Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19, Stress Reaction; Acute
- Trial name
- NCT05923398
- Testing
- Digital Intervention Group
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Stress Disorders, Post-Traumatic, Depression
Resettled Refugee Families for Healing
The goal of this type I hybrid effectiveness-implementation trial is to test a family strengthening (FS) model delivered through multiple family groups (MFG) combined with a virtual peer mentoring program called TeenAge Health…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Antisocial Personality Disorder, Anxiety
- Trial name
- RRF4H (NCT06176638)
- Testing
- RRF4H Combination Intervention
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Post Traumatic Stress Disorder, Resuscitated Sudden Cardiac Death
Psychological Sequelae After Sudden Cardiac Death in the Patient and His Relatives
This study will evaluate and describe the occurrence of Acute traumatic stress and persistence of Post Traumatic Stress Disorder (PTSD) after resuscitated sudden cardiac death (SCD) in patient and relatives present during the…
- Trial name
- TEMPO (NCT04921514)
- Testing
- SASRQ questionnaire, PCL-5 with LEC-5 questionnaire
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Brain Injuries, Traumatic, Spinal Cord Trauma
Characterization of Human Autoantibody Titers After Central Nervous System Insult
The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
- Conditions
- Brain Injuries, Traumatic, Spinal Cord Trauma, Intracranial Neoplasm
- Trial name
- CHAT CNS (NCT03089749)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Utah
TBI
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as…
- Trial name
- NCT02990078
- Testing
- Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Concussion
Control Study of Nautilus BrainPulse for the Detection of Concussion
To use the Nautilus BrainPulse to compare and contrast the signal patterns from this cohort's signal patterns with those of concussed high school athletes.
- Trial name
- NCT02350699
- Testing
- Nautilus BrainPulse
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Stress Disorders, Post-Traumatic, Tinnitus
Network Dysregulation Among Individuals With Comorbid Tinnitus and PTSD
Evaluation of the overlap between tinnitus-related distress and symptoms of Post Traumatic Stress Disorder (PTSD), to identify functional covariance among resting-state networks among individuals with tinnitus and PTSD
- Trial name
- NCT03702166
- Testing
- Cognitive Processing Therapy (CPT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cerebral Hypoxia, Severe Traumatic Brain Injury
Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit.
Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate.
- Trial name
- NCT06306950
- Testing
- Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Post-traumatic Stress Disorder, Acute Stress Disorder
Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience
The study aims to assess the feasibility of an online intervention platform based on the Immediate Stabilization Procedure (ISP®). This intervention targets early trauma reactions, aiming to reduce the risk of future PTSD.
- Trial name
- NCT06277973
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Stress Disorders, Post-Traumatic
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck)…
- Trial name
- NCT05889741
- Testing
- Ropivacaine injection, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Concussion, Mild, Convergence Insufficiency
Spectacles Lens in Concussed Kids
We will be looking at 3 treatment arms in the form of different type of glasses to see if one is superior to helping kids have sustained a concussion and are symptomatic.
- Conditions
- Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
- Trial name
- SLICK (NCT03123822)
- Testing
- Glasses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Post-traumatic Stress Disorder
Program for Alleviating and Resolving Trauma and Stress 2
This pilot RCT will test the preliminary efficacy of an intensive group model of Internal Family Systems (IFS) called the Program for Alleviating and Resolving Trauma and Stress (PARTS) compared with a Nature-Based Stress…
- Trial name
- PARTS2 (NCT05095428)
- Testing
- PARTS Program, NBSR-T Program
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Military Physical and Sexual Trauma, Combat Trauma
Deployment Health in Regular Military Women
The purpose of this study is to determine potential risk factors for physical and sexual assault in regular military women (as opposed to Reserve and National Guard).
- Conditions
- Military Physical and Sexual Trauma, Combat Trauma, PTSD, TBI
- Trial name
- DHRMS (NCT01692067)
- Where
- 2 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
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