Clinical trials: Traumatic Injuries
Post-Traumatic Stress Disorder
Role of Substance P in Post-Traumatic Stress Disorder
This study will examine the role of substance P, a chemical messenger in the brain, in post-traumatic stress disorder (PTSD), a chronic anxiety disorder.
- Trial name
- NCT00102102
- Testing
- [18F]SPA-RQ
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Brachial Plexus Injury, Respiratory Evaluation
Surgical Repercussions in Respiratory System in Patients With Post-Traumatic Brachial Plexus Injuries: A Prospective Cohort Study
To evaluate the surgical repercussions in patients with traumatic brachial plexus injury in the respiratory and motor systems, trunk biomechanics, functional capacity and quality of life.
- Trial name
- NCT03377712
- Testing
- optoelectronic plethysmography, diaphragmatic ultrasound, Postural evaluation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Evaluation of Helmet Technology and Head Impact Exposure
The purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of football playing athletes grouped by helmet make and model.
- Trial name
- NCT03883451
- Testing
- Helmet Model
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression, Anxiety, PTSD
A Scalable Model for Promoting Functioning and Well-Being Among Veterans With a History of Mental Health Challenges Via Meaningful Social Interactions: Project V-SPEAK!
The goal of this study is to refine and test a strategy for engaging veterans with symptoms of depression and/or anxiety as volunteers to help English language learners (ELLs) improve their speaking skills via structured…
- Trial name
- V-SPEAK! (NCT05506839)
- Testing
- Intervention (videoconferencing)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post-Traumatic Stress Disorder, PTSD, Alcohol Use Disorder (AUD)
Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974
Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974
- Trial name
- NCT07488819
- Testing
- PF974
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yale University
Concussion, Mild
Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes
Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as measured by 31P MRS?
- Trial name
- TRMC-004 (NCT02721537)
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Traumatic Brain Injury
Traumatic Brain Injury and Yoga
This long-term goal of this project was to advance best practices in occupational therapy in conjunction with yoga. To address the long-term goal, this research team developed a pilot yoga intervention.
- Trial name
- NCT03008434
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Head Injury Trauma
Osteopathic Manipulative Treatment RCT and Computational Modeling for Head Injuries in Mixed Martial Artists
The purpose is to test how osteopathic medicine (OMM) improves recovery after a hit to the head during Mixed Martials Arts (MMA).
- Trial name
- NCT06851234
- Testing
- osteopathic manipulative medicine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Rotator Cuff Tear or Rupture, Not Specified as Traumatic
Superior Glenohumeral Translation in Patients With Degenerative Rotator Cuff Tears
Degenerative partial and complete rupture of the rotator cuff is a common injury among elder patients. However, the clinical manifestation varies largely with some patients having severe pain and limiting range of motion and…
- Trial name
- ROTCUFF (NCT03717571)
- Testing
- Glenohumeral translation assessment
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Brain Injuries, Traumatic, Post-traumatic Stress Disorder
Morning Bright Light to Improve Sleep Quality in Veterans
One of the principal complicating factors associated with traumatic brain injury (TBI) is sleep-wake disturbances (e.g., insomnia, excessive daytime sleepiness, and circadian rhythm sleep disorders).
- Trial name
- NCT03578003
- Testing
- Morning Bright Light Therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Traumatic Brain Injury
Evaluating Huddles as a Novel Approach to Improving Concussion Safety
Investigators will conduct a randomized controlled trial assessing the effectiveness and implementations of Pre-Game Safety Huddles (Huddles) in youth soccer.
- Trial name
- NCT06864611
- Testing
- Pre-Game Safety Huddles
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Concussion
Pathology in the Brain After mTBI - A Multimodal MRI Study
The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the…
- Trial name
- NCT01936792
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Substance Use Disorders, Drug Abuse
Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users
The unmet need for effective addiction treatment within the criminal justice system "represents a significant opportunity to intervene with a high-risk population" according to NIDA's 2016-2020 strategic plan.
- Conditions
- Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT04007666
- Testing
- Cognitive Processing Therapy, Control Group
- Where
- 2 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Brain Injuries, Brain Diseases
Influence of Physical Exercise on Cognitive Functioning of Traumatic Brain Injury Patients
The aim of this study is to determine the effects of an acute session of physical exercise on cognitive functioning and humor of traumatic brain injury patients and to investigate whether different cognitive responses can be…
- Conditions
- Brain Injuries, Brain Diseases, Central Nervous System Diseases, Craniocerebral Trauma
- Trial name
- NCT01395472
- Testing
- Acute Physical Exercise, Stretching protocol
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Post-Concussion Syndrome
Move&Connect: A Program for Youth With Concussion and Their Caregivers.
Move\&Connect is an interdisciplinary group-based program co-designed with youth and caregivers that provides skills training, mental health support, and psychoeducation to caregivers and combines these tenets with active…
- Trial name
- NCT05631301
- Testing
- Exercise Circuits, Goal Setting, Psychoeducation-Youth
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Concussion, Mild
Reverse King-Devick Test and History of Multiple Concussions
The purpose of this study is to examine the effects of concussion history and reading direction on baseline King- Devick Test (KDT) performance, a common component of sideline concussion assessments.
- Trial name
- NCT04560400
- Testing
- Conventional King-Devick test, Reverse King-Devick test
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Traumatic Stress Disorder
Exposing Narrative Exposure Therapy
The main purpose of the study is to further develop an existing measure of autobiographical memory integration (ABMI) to investigate and clarify the ABMI change process specific to narrative exposure therapy (NET).
- Trial name
- NCT05383846
- Testing
- Experimental Narrative Exposure Therapy
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
PTSD
Building Experience for Treating Trauma and Enhancing Resilience (BETTER)
Posttraumatic stress disorder (PTSD) is a significant problem among underserved populations who receive care in community health centers.
- Trial name
- BETTER (NCT05330442)
- Testing
- Written Exposure Therapy (WET)
- Where
- 10 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- RAND
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