Clinical trials: Traumatic Injuries
Posttraumatic Stress Disorder, PTSD
Mothers Overcoming and Managing Stress
The study is a randomized trial of two manualized 12-session one-to-one educational and therapeutic interventions for post-traumatic stress disorder (PTSD), to test and compare their efficacy for reducing PTSD symptoms as a means…
- Trial name
- MOMS (NCT00751244)
- Testing
- Trauma Affect Regulation: Guide for Education and Therapy, Present Centered Therapy (PCT) - psychotherapy, No-treatment "waitlist" group
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- UConn Health
Pediatric Traumatic Brain Injury
Validating a Blood Test for the Detection of Traumatic Brain Injury in Children
The primary objective of this study is to establish if Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) are predictive of computed tomography (CT) findings in pediatric traumatic brain…
- Trial name
- NCT06940232
- Testing
- Blood Test for Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acute Biomarkers
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Nebraska
Stress, Psychological, Post-Traumatic Stress Disorder
Intervention to Reduce Stress in 0-5 Year Olds With Burns
The objectives of this study are to test and validate a simple, feasible intervention to reduce pediatric burn traumatic stress in 0-5 year old children and their parents.
- Conditions
- Stress, Psychological, Post-Traumatic Stress Disorder, Major Injury
- Trial name
- NCT00844896
- Testing
- DEF-only, DEF + COPE
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Massachusetts General Hospital
Cranioplasty, Disability Physical
Does Cranioplasty Reduce Disability in Cases With Post Traumatic Skull Bone Defects
Background: The percentage of permanent infirmities following traumatic cranial bone cranial bone defects following trauma for restoration of function and cosmoses.
- Conditions
- Cranioplasty, Disability Physical, Trauma
- Trial name
- Cranioplasty (NCT04111562)
- Testing
- Cranioplasty
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Assiut University
Prolonged Post-traumatic Stress Disorder
Meditation for Emotional Numbing in Post-Traumatic Stress Disorder
For individuals suffering from posttraumatic stress disorder (PTSD), the emotional numbing and isolation that are a core aspect of their suffering and consistently impedes remediation often remains after first-line treatments are…
- Trial name
- NCT02163941
- Testing
- Compassion Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
Traumatic Brain Injury
Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells
The purpose of this study is to determine if bone marrow harvest, BMMNC separation, and re-infusion in adults with acute severe TBI is safe and will improve functional outcome.
- Trial name
- NCT01575470
- Testing
- autologous bone marrow mononuclear cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center, Houston
Subdural Hematoma, Subdural Hematoma, Chronic
Study On Histoacryl Used For Embolization Of Middle Meningeal Artery (MMA) In Chronic Subdural Hematoma (CSDH)
The aim of the study is to proof the effectiveness of Histoacryl® on preventing recurrence or progression of subdural hematoma after embolization of the middle meningeal artery.
- Trial name
- HARMONY (NCT07258069)
- Testing
- Histoacryl®
- Where
- 6 sites in Japan
- Volunteers
- 178 people
- Sponsor
- Aesculap AG
Traumatic Brain Injury
Gaining Real-Life Skills Over the Web
Gaining Real-life Skills Over the Web (GROW) is an online parenting-skills intervention for caregivers of children aged 0-4 who sustained traumatic brain injuries.
- Trial name
- GROW (NCT05160194)
- Testing
- Positive Parenting Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV, Stress Disorder
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
The purpose of this study is to create a smartphone, tablet and web-based application to help people deal with stress. Stress often increases fatigue in people with HIV infection, so successfully dealing with stress could help…
- Conditions
- HIV, Stress Disorder, Human Immunodeficiency Virus, Fatigue
- Trial name
- NCT03149094
- Testing
- CBSM-SMI, CBSM-SMI control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Dementia, Mixed, Dementia of Alzheimer Type
REACH Hope Intervention for Dementia and TBI Caregivers
This three-year randomized clinical trial will evaluate a behavioral intervention for caregivers of Veterans with traumatic brain injury (TBI) and Alzheimer's dementia or mixed Dementia (AD/MD) to reduce caregiver depression…
- Conditions
- Dementia, Mixed, Dementia of Alzheimer Type, TBI (Traumatic Brain Injury)
- Trial name
- REACH Hope (NCT04969796)
- Testing
- REACH Hope
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Memphis VA Medical Center
Post-Traumatic Stress Disorder, Depression
Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era
Little is known about the long-term health and mental health status of women Vietnam veterans. For many of these women, the effects of this war are still present in their daily lives.
- Conditions
- Post-Traumatic Stress Disorder, Depression, Diabetes, Cardiovascular Disease
- Trial name
- Health ViEWS (NCT00958061)
- Where
- United States
- Volunteers
- 4,219 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post-Concussion Syndrome, Mild Traumatic Brain Injury
Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury
Neck pain, dizziness and headache are common symptoms following mild traumatic brain injury (mTBI). The efficacy of cervical spine and vestibular-ocular system impairments intervention need to be determined.
- Conditions
- Post-Concussion Syndrome, Mild Traumatic Brain Injury, Vestibular Disorder, Whiplash Injuries
- Trial name
- NCT03677661
- Testing
- Conventional approach, Personalized rehabilitation program
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Post Traumatic Stress Disorder
Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress
Populations facing health disparities include groups with significantly higher rates of posttraumatic stress disorder than the general population who frequently experience lived experience stress, which may complicate…
- Trial name
- NCT07714083
- Testing
- Standard CPT, CPT-LEAP
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston University
Post-Traumatic Stress Disorder
Comparison of Two Treatments for Post-Traumatic Stress Disorder
This study will compare the short- and long-term effectiveness of two different treatments for people with post-traumatic stress disorder.
- Trial name
- NCT00127673
- Testing
- Sertraline, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Chronic Condition, Chronic Pain
RIVER At Home Ketamine Protocols
Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior.
- Conditions
- Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder
- Trial name
- NCT06070766
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- RIVER Foundation
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Pharmacokinetic Study, Post Traumatic Stress Disorder
Pharmacokinetic Study for IV Allopregnanolone
About 6.4% of the U.S. population suffers from posttraumatic stress disorder (PTSD). Trauma-focused psychotherapies are generally effective in PTSD, but responses vary greatly across individuals and PTSD subpopulations.
- Trial name
- NCT04468360
- Testing
- PK-1 Good Manufacturing Practices (GMP) allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis, PK-2 GMP allopregnanolone (Allo) with Dexolve in 0.9% saline for infusion manufactured by the University of California, Davis.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Depressive Symptoms, Emotional Depression
Parenting-STAIR Modular for Military Fathers and OCONUS Families
The goal of this clinical trial is to learn if a family-based treatment called Parenting-STAIR-Modular (PSTAIR-M) can help military parents recover from trauma, strengthen emotion regulation skills, and improve parent-child…
- Conditions
- Depressive Symptoms, Emotional Depression, Depression, Parent Child Relationship
- Trial name
- NCT07843654
- Testing
- Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 243 people
- Sponsor
- New York University
Brain Injury, Craniocerebral Trauma
PariS-TBI Study : Paris Severe Traumatic Brain Injury Study
The primary objective of the protocol is to study the long-term outcome of a large group of traumatic brain injury patients. This outcome is to be described in terms of activity, participation, quality of life, SOCIO-professional…
- Conditions
- Brain Injury, Craniocerebral Trauma, Trauma Nervous System
- Trial name
- PariS-TBI (NCT01437683)
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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