Clinical trials: Traumatic Injuries
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Smoking, Stress Disorders, Post-Traumatic
CPT-SMART for Treatment of PTSD and Cigarette Smoking
Smoking is the leading cause of preventable illness, disability, and death in the United States. The rate of smoking is disproportionately higher among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- CPT-SMART (NCT03978442)
- Testing
- Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Chronic Troublesome Sialorrhea, Parkinson's Disease
Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions
The objective of this study is to investigate the efficacy and safety of two different dose levels of NT 201 (75 U or 100 U per cycle), compared with placebo, in reducing the salivary flow rate, and the severity and frequency of…
- Conditions
- Chronic Troublesome Sialorrhea, Parkinson's Disease, Post-stroke, Traumatic Brain Injury
- Trial name
- SIAXI (NCT02091739)
- Testing
- IncobotulinumtoxinA (100 Units), IncobotulinumtoxinA (75 Units)
- Where
- 31 sites in Germany, Poland
- Volunteers
- 184 people
- Sponsor
- Merz Pharmaceuticals GmbH
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Injury Traumatic
PRACT to Investigate Controlling Alcohol Related Harms in a Low-Income Setting; Emergency Department BIs in Tanzania
Alcohol use is rapidly increasing in low- and middle-income countries, where it is inexpensive, readily available, poorly regulated, and there are few resources devoted to promoting safe alcohol use.
- Conditions
- Alcohol Use Disorder, Injury Traumatic, Trauma
- Trial name
- PRACT (NCT04535011)
- Testing
- PPKAY (brief intervention), Standard Booster, Personalized Booster
- Where
- Tanzania
- Volunteers
- 673 people
- Sponsor
- Duke University
Stress Disorders, Posttraumatic, Depression
Re-Engineering Systems for the Primary Care Treatment for PTSD
The study is an evaluation of a systemic intervention to enhance the delivery of care according to practice guidelines for posttraumatic stress disorder (PTSD).
- Trial name
- RESPECT-PTSD (NCT00373698)
- Testing
- Three Component Model of Collaborative Care
- Where
- 4 sites in United States
- Volunteers
- 195 people
- Sponsor
- US Department of Veterans Affairs
Anxiety, Depression
Improving Obesity Self-Care Among Mentally Ill Veterans
The purpose of this study is to find out which of two programs, MH MOVE! or the enhanced usual care MOVE! program is most effective in improving participation in and completion of MOVE! among Veterans with depression, anxiety…
- Conditions
- Anxiety, Depression, PTSD, Obesity
- Trial name
- MH MOVE! (NCT02642536)
- Testing
- MH MOVE, Enhanced Usual Care
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Secondary Prevention With Paroxetine vs. Placebo in Subthreshold Posttraumatic Stress Disorder (PTSD)
The purpose of this study is: 1) To document the effectiveness and tolerability of paroxetine for the treatment of subthreshold posttraumatic stress disorder (PTSD) in veterans in the early post-deployment period; and 2) To…
- Trial name
- NCT00560612
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Durham VA Medical Center
Concussion
Protection Against Potential Brain Injury During Competitive Football
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). An externally-worn medical device that applies mild jugular compression according to the principle of the Queckenstedt Maneuver (the…
- Trial name
- NCT02696200
- Testing
- Q Collar
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Posttraumatic Stress Disorder, Depression
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to test the effectiveness of group psychotherapy designed specifically for male veterans and active-duty personnel with Post-traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD) and with…
- Conditions
- Posttraumatic Stress Disorder, Depression, Insomnia Disorder
- Trial name
- NCT00984698
- Testing
- Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
Posttraumatic Stress Disorder
Narrative Exposure Therapy (NET)
The purpose of this study is to learn more about Narrative Exposure Therapy for Justice Involved Veterans. This pilot study will examine the feasibility of this intervention in a justice-involved veteran population, and will see…
- Trial name
- NET (NCT03777553)
- Testing
- Narrative Exposure Therapy for Justice-Involved Veterans
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Depression, Stress Disorders, Post-Traumatic
Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs
Electronic screening is effective for timely detection of, and intervention for, suicidal ideation and other mental health symptoms.
- Conditions
- Depression, Stress Disorders, Post-Traumatic, Suicide
- Trial name
- NCT04506164
- Testing
- eScreening, Screening As Usual
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hemorrhagic Shock, Traumatic Brain Injury
Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
The LITES Network is an operational trauma center consortium which has the expertise, track record and confirmed capabilities to conduct prospective, multicenter, injury care and outcomes research of relevance to the Department…
- Trial name
- SWAT (NCT03402035)
- Where
- United States
- Volunteers
- 1,051 people
- Sponsor
- University of Pittsburgh
Blepharoptosis, Ptosis, Eyelid
Clinical Trial to Improve the Magnetic Levator Prosthesis
Blepharoptosis (incomplete opening of the eyelids) occurs because of a disruption in the normal agonist-antagonist neuro-muscular complex balance. An external device could restore eyelid movement.
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT03818204
- Testing
- Magnetic Levator Prosthesis (MLP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Major Depressive Disorder, Posttraumatic Stress Disorder
Comparing Group Therapies for Veterans With Depression and PTSD
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and PTSD. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost…
- Trial name
- NCT03979040
- Testing
- Group Transdiagnostic Behavior Therapy, Group Disorder-Specific Therapy (G-DSTs)
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Growth Hormone Deficiency, Traumatic Brain Injury
Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by GH stimulation testing.
- Trial name
- NCT00957671
- Testing
- Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Medical Branch, Galveston
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
TBI (Traumatic Brain Injury)
A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection
The purposes of this study are: 1. To determine the sensitivity and specificity of the Near-Infrared Spectroscopy (NIRS) measurements for identifying intracranial hematomas due to trauma. 2.
- Trial name
- NCT00576147
- Testing
- Infrascanner
- Where
- 4 sites in United States
- Volunteers
- 431 people
- Sponsor
- InfraScan, Inc.