Clinical trials: Traumatic Injuries
Post Traumatic Stress Disorder
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD
The goal of this exploratory, mixed-method design study is to gather qualitative and quantitative data obtained through interviews and questionnaires with veterans who are currently enrolled at the VA for healthcare.
- Trial name
- PMATAVP (NCT05895318)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Albany Research Institute, Inc.
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Stress Disorders, Post-Traumatic
Gene Expression Correlates of Post-Traumatic Stress Disorder (PTSD) Symptom Change After EFT (Emotional Freedom Techniques)
The purpose of the study is to measure the change in psychological symptoms and gene expression in war veterans after a series of 10 EFT coaching sessions.
- Trial name
- NCT01250431
- Testing
- EFT (Emotional Freedom Techniques)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Traumatic Brain Injury
Micronutrient Supplement Effects on Cognitive Outcomes in Post-Acute TBI
Traumatic brain injury (TBI) refers to neuronal damage occurring as the result of an external force being applied to brain tissue.
- Trial name
- NCT03032302
- Testing
- Swisse Womens 50+ Ultivite Multivitamin, Holland and Barrett Triple Strength Omega-3 Fish Oil
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Hallam University
Convergence Insufficiency
Home-based Vision Therapy
Post-concussive vision symptoms affect many Veterans who have experienced traumatic brain injury (TBI). One common issue is trouble with near vision, a problem that may persist long after the acute injury.
- Trial name
- NCT06886737
- Testing
- Virtual-reality convergence training game
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Computer Assisted Lessening of Intrusive Memories in the Emergency Department
During the COVID-19 pandemic, clinical staff working in frontline NHS hospital and pre-hospital departments (e.g. emergency department, intensive care unit, ambulance service) are being faced with difficult and stressful…
- Trial name
- CALM-ED (NCT04769999)
- Testing
- Simple cognitive task
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Oxford
Dizziness, Brain Injury
Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
The purpose of this project is to determine the effects of mild traumatic brain injury and blast exposure on the inner ear balance and central nervous systems.
- Trial name
- NCT01021137
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Subdural Hematoma
Tranexamic Acid Therapy For The Treatment of Subdural Hematomas
This Phase II randomized, placebo-controlled, double-blinded trial is the first step in our endeavor to improve the clinical outcomes of patients with chronic subdural hematomas (cSDH).
- Trial name
- NCT06718751
- Testing
- Tranexamic Acid 650 MG
- Volunteers
- 240 people
- Sponsor
- Baylor College of Medicine
Earthquake, Stress Disorders, Post-Traumatic
The Effect of Exercise on Post-traumatic Stress Disorder and Sleep Quality in Individuals Affected by the 2023 Kahramanmaraş Earthquakes
Natural disasters can have adverse impacts on both physical and mental health. Post-traumatic stress disorder (PTSD) and sleep disorders are among the most common problems seen after natural disasters.
- Trial name
- NCT06388876
- Testing
- Exercise, lifestyle advice
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Brain Injury, Chronic
Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT00810615
- Testing
- Hyperbaric oxygen @ 2.4 ATA
- Volunteers
- 50 people
- Sponsor
- San Antonio Military Medical Center
Stress Disorders, Post-Traumatic, Retinal Detachment
Diagnosis of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment
To investigate the prevalence of posttraumatic stress disorder (PTSD) in patients that underwent surgery for primary rhegmatogenous retinal detachment (RRD) and to determine variables associated with the disorder.
- Trial name
- NCT01233908
- Where
- Israel
- Volunteers
- 547 people
- Sponsor
- Sheba Medical Center
PTSD, Post Traumatic Stress Disorder PTSD
Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)
The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in…
- Conditions
- PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT07523685
- Testing
- non-invasive vagus nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Acacia Clinics
Brain Injury Traumatic Mild
Spotting and Managing Adult Repeated Traumas in the Brain
Emerging evidence suggests that concussions (a type of mild traumatic brain injury; mTBIs) may cause chronic neurological disturbances with effects lasting beyond 20 years, changing brain structure and nearly doubling the risks…
- Trial name
- SMARTBRAIN (NCT07025317)
- Testing
- Perceptual-cognitive
- Where
- 3 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Musculoskeletal Pain, Injuries
Modeling Post-traumatic Pain and Recovery: The SYMBIOME Longitudinal Cohort Study
This study will explore the contribution of stress-system activity to pain and functional disability in the acute stage of traumatic musculoskeletal injury, and to the maintenance of symptoms after 3, 6 and 12 months post-injury.
- Trial name
- SYMBIOME (NCT02711085)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stress Disorders, Post-Traumatic
Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder
This study, conducted at the University of Pennsylvania and at the National Institutes of Health in Bethesda, Maryland, will examine deficits in brain structure and function in people exposed to trauma who developed…
- Trial name
- NCT00069225
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder, Substance Use Disorders
Adaptation of Written Exposure Therapy in Substance Treatment
The purpose of this pilot non-randomized, uncontrolled clinical trial is to test the feasibility and efficacy of written exposure therapy (WET) for posttraumatic stress disorder (PTSD) as adapted for use within the context of…
- Trial name
- WEST (NCT07108608)
- Testing
- Written Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Potomac Health Foundations
Brain Concussion
Problem-Solving Training for Concussion
Mild traumatic brain injury (mTBI), also known as concussion, is a common injury sustained by Veterans. While most individuals who sustain mTBI experience a complete recovery within several weeks of injury, many Veterans with…
- Trial name
- PST-Concussion (NCT05837676)
- Testing
- Problem Solving Training for Concussion, Treatment as usual
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- VA Office of Research and Development
Concussion (Diagnosis)
Sports-related Concussion: Physiological, Biomechanical and Cognitive Methodology
The study aims to investigate the changes in physiological, biomechanical and cognitive performance under a traumatic sport-event (i.e., rugby match).
- Trial name
- NCT04841876
- Testing
- rugby matches
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Traumatic Brain Injury
Physical Work Capacity After Traumatic Brain Injury
The purpose of this study is to determine whether body weight supported treadmill training is more effective than traditional physical therapy at restoring gait in persons recovering from traumatic brain injury.
- Trial name
- NCT00653640
- Testing
- body weight supported treadmill training, traditional physical therapy
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- The University of Texas Medical Branch, Galveston
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