Clinical trials: Traumatic Injuries
Mild Traumatic Brain Injury, Concussion
A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury
This is a Phase IIa, randomized, double-blind, placebo-controlled pilot study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ONP-002 in adults with mild traumatic brain injury (mTBI).
- Trial name
- NCT06870240
- Testing
- Neurosteroid enantiomer
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Oragenics, Inc.
Stress Disorders, Post-Traumatic
Post Traumatic Stress Disorder (PTSD), Sleep Disordered Breathing And Genetics: Effects On Cognition
The current research program aims to study how sleep disordered breathing, age and genetics affect memory in older adult veterans with Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01120847
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Stanford University
Ankle Fractures, Post-traumatic Osteoarthritis
Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle. Research suggests that ankle arthritis develops following ankle fracture due, in part, to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP FPA CT (NCT05209347)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Sponsor
- University of Iowa
Trauma, Psychological, Traumatic Stress Disorder
The Effect of Dual Attention in an EMDR Intervention
Research to date indicates that trauma-focused treatments are safe and effective for PTSD, even when higher-risk comorbidities (e.g., psychosis or substance use) are present.
- Trial name
- DA_EMDR (NCT05600868)
- Testing
- A comprehensive third-generation intervention EMDR + dual attention, A comprehensive third-generation intervention EMDR + fixed point, A comprehensive third-generation intervention EMDR + exposition
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Post-Traumatic Headache
Behavior Therapy vs Education for Persistent Headache After Mild TBI
This study will test a new treatment, called Headache reprocessing, for persistent post-traumatic headache. The new treatment will be compared to a headache education intervention.
- Trial name
- NCT07229391
- Testing
- Headache reprocessing, Headache education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Depressive Symptoms, Stress Disorder, Acute
Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART)
In brief, ART is an innovative "mind-body" (body-centric) psychotherapy that makes use of established core components of trauma-focused therapy including imaginal exposure and imagery rescripting to promote memory…
- Conditions
- Depressive Symptoms, Stress Disorder, Acute, Prolonged Grief Disorder, Alcohol Abuse
- Trial name
- M-ART (NCT04121884)
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Depression, Panic Disorder
Evaluating the Effects of Stress in Pregnancy
This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy.
- Conditions
- Depression, Panic Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00525226
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- Emory University
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury
Adaptation of the STAIR-NT for First Responders
This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with…
- Trial name
- NCT07212140
- Testing
- Adapted STAIR-NT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Florida State University
Traumatic Brain Injury
Therapeutic Normothermia in TBI
This feasibility trial is the first step in testing the hypothesis that maintenance of normal body temperature, called therapeutic normothermia (TN), for 72 continuous hours in traumatic brain injury (TBI) patients can improve…
- Trial name
- MAMBA-FT (NCT06540768)
- Testing
- Therapeutic Normothermia Group
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre
Brain Injury Traumatic Severe, Disorder of Consciousness
Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness
This study first aims to validate the feasibility of a multimodal 5-day 20-minute tACS protocol in subacute brain-injured patients with a disorder of consciousness during their ICU stay, and conduct a clinical pilot study…
- Conditions
- Brain Injury Traumatic Severe, Disorder of Consciousness, Brain Injuries
- Trial name
- NCT05833568
- Testing
- Active Transcranial alternative current stimulation
- Volunteers
- 138 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Bone Marrow Transplant Complications
Virtual Reality Intervention for Patients Undergoing BMT
The goal of this research study is to test the feasibility and preliminary efficacy of using a virtual reality (VR) psychosocial intervention for improving quality of life and psychological distress in patients hospitalized for…
- Trial name
- NCT05629676
- Testing
- BMT-VR
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Acute Brain Injuries, TBI (Traumatic Brain Injury)
Dynamic and Static Autoregulation After Brain Injury
The aim of the study assesses static and dynamic cerebrovascular autoregulation daily over one week in patients with traumatic brain injury or intracranial hemorrhage to quantify the temporal profile of the autoregulatory status.
- Conditions
- Acute Brain Injuries, TBI (Traumatic Brain Injury), Intracranial Hemorrhages
- Trial name
- NCT01069250
- Testing
- There are no interventions in this study
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Johannes Gutenberg University Mainz
Intensive Care Unit
Citicholine-Amantadine Trial in Traumatic Brain Injury
This randomized study aims at comparing between the effects of amantadine, citcholine and its combinations on arousal and behavioral consequences in early phase of moderate Traumatic Brain injury (TBI).
- Trial name
- NCT03430817
- Testing
- Citicholine, Amantadine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Traumatic Brain Injury
Translation of Modified Fatigue Impact Scale in Urdu Language
Cross cultural analytical study to translate Modified fatigue impact scale MFIS) in Urdu language. Along with the translated version by evaluating its validity and reliability among the patients of traumatic brain injury.
- Trial name
- NCT05405517
- Where
- Pakistan
- Volunteers
- 105 people
- Sponsor
- Riphah International University
Alcohol Use Disorder, Mild Traumatic Brain Injury
Virtual Reality- Working Memory Retraining
This study will establish the acceptability and feasibility of enrolling and retaining heavy drinking Veterans with mild traumatic brain injury (mTBI) in an 8-week, randomized cross-over design trial of active VR working memory…
- Trial name
- VR-WMR (NCT03786276)
- Testing
- VR-WMR-Only, Exercise-only, Active VR-WMR
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics
To improve patient selection for head CT, a safe and high sensitivity screening neuroimaging modality is needed. Currently many clinicians must make treatment decisions based solely on the patients clinical exam, which has low…
- Trial name
- CUPID-Peds (NCT06697808)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Wake Forest University Health Sciences
Post Traumatic Stress Disorder
Online PTSD Treatment for Young People and Carers - Case Series
Post Traumatic Stress Disorder (PTSD) is prevalent and impairing in children and young people. Effective face to face treatments exist, including Cognitive Therapy for PTSD (CT-PTSD), developed by the researchers' group.
- Trial name
- OPTYC (NCT03935035)
- Testing
- internet-delivered Cognitive Therapy for PTSD (iCT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- King's College London
Traumatic Brain Injury (TBI) Patients
Chromatic Multifocal Pupillometer for Detection and Follow-up of Acute Head Injury
Traumatic Brain Injury (TBI) is a common injury in combat, terrorist attacks and sports such as football and hockey. Unnecessary delays in the diagnosis and treatment of brain damage in patients who can benefit from evacuation…
- Trial name
- NCT02030366
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cardiopulmonary Bypass, Intensive Care Units
Preventive Narrative Exposure Intervention for PTSD in ICU Patients After Cardiopulmonary Bypass Cardiac Surgery
This clinical trial aims to evaluate whether an ICU-based preventive narrative exposure intervention can help prevent posttraumatic stress symptoms in adult patients after cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiopulmonary Bypass, Intensive Care Units, Stress Disorders, Post-Traumatic
- Trial name
- ICU-pNET (NCT07632131)
- Testing
- ICU-Based Preventive Narrative Exposure Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
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