Clinical trials: Traumatic Nerve Injury
Traumatic Brain Injury
Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation
The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous auricular vagus nerve stimulation (tVNS) to enhance cognitive recovery in patients with mild-moderate traumatic brain injury…
- Trial name
- NCT06589362
- Testing
- Transcutaneous auricular vagus active nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
PostTraumatic Stress Disorder
Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder
The tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs.
- Trial name
- NCT02992899
- Testing
- GammaCore/electroCore non-invasive VNS device, O-15 water
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Emory University
Traumatic Optic Neuropathy
Traumatic Optic Neuropathy Treatment Trial (TONTT)
The pathophysiology of Traumatic Optic Neuropathy (TON) is thought to be multifactorial, and some researchers have also postulated a primary and secondary mechanism of injury.TON is categorized as direct or indirect.In indirect…
- Trial name
- TONTT (NCT01783847)
- Testing
- Recombinant human erythropoietin (EPO), Observation, Methyl prednisolone
- Where
- 3 sites in Iran
- Volunteers
- 117 people
- Sponsor
- Tehran University of Medical Sciences
Soft Tissue Injuries, Distal Radius Fracture
Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers.
Trauma and soft injuries of the wrist, hand and fingers have a high incidence, and large social and healthcare costs are generated, mainly due to productivity loss.
- Conditions
- Soft Tissue Injuries, Distal Radius Fracture, Metacarpal Fracture, Carpal Fracture
- Trial name
- NCT04669704
- Testing
- Experimental: Tablet application, Comparator: Conventional treatment
- Where
- 2 sites in Spain
- Volunteers
- 663 people
- Sponsor
- University of Seville
Optic Nerve Sheath, Hypertonic Saline
Point of Care Optic Nerve Sheath Ultrasound to Assess Intracranial Pressure
Elevated intracranial pressure (ICP) is one of the most common symptoms encountered in a variety of traumatic injuries and diseases.
- Trial name
- NCT04686344
- Testing
- intermittent boluses of Hypertonic saline, continuous infusion of Hypertonic saline
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Leg Pain, Peripheral Nerve Discontinuities
Effect of Nerve Stimulation on Sciatic Nerve Injury Pediatric Patients
Brief Summary The goal of this study is to learn if Faradic Nerve Stimulation (FNS) can help children recover from a condition called Post-Injection Sciatic Nerve Injury (PISNI).
- Conditions
- Leg Pain, Peripheral Nerve Discontinuities, Muscle Weakness, Sciatic Nerve Compression
- Trial name
- PISNI (NCT06781060)
- Testing
- Faradic Nerve Stimulation Therapy+Standard Physiotherapy, Physiotherapy Standard Treatment with TENS machine therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Azeem Hospital, Multan
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Neuromodulation to Manage Chronic Pain
In Canada, veterans suffer from chronic pain at twice the rate of the general population. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Trial name
- VR & CN-NINM (NCT07065396)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Mindful RAVANS Study
This pilot study is testing a new treatment for people who still have frequent headaches months after a mild traumatic brain injury, with about half of the participants coming from military or veteran backgrounds.
- Conditions
- mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Headache
- Trial name
- RAVANS (NCT07872761)
- Testing
- Cala-RAVANS (Model CR-2)
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Finger Injuries, Procedural Pain
Topical Lidocaine for Digital Nerve Block Pain
The goal of this clinical trial is to determine whether topical lidocaine spray applied to the wound before digital nerve block can reduce injection-related pain in patients with finger lacerations.
- Trial name
- NCT07834866
- Testing
- Topical Lidocaine Spray
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Ankara City Hospital Bilkent
PTSD - Post Traumatic Stress Disorder
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma.
- Trial name
- SPARK-VNS (NCT06953388)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wayne State University
Traumatic Brain Injury
TCD and ONSD for Early Risk Stratification of Traumatic Brain Injury
This observational study aims to evaluate the combined use of transcranial Doppler (TCD) and optic nerve sheath diameter (ONSD) ultrasound for early risk stratification of adults with traumatic brain injury (TBI) presenting to…
- Trial name
- TCD-ONSD (NCT07820527)
- Testing
- Transcranial Doppler and Optic Nerve Sheath Diameter Assessment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Increase Intra Cranial Pressure, Traumatic Brain Injury
Diagnostic Accuracy of the Optic Nerve Deformability Index and Optic Nerve Sheath Diameter as a Noninvasive Predictor of Intracranial Pressure
The study will be carried out on 50 patients, dichotomized into high and normal ICP groups, and we will assess both ONSD and DI in all patients.
- Trial name
- NCT06884319
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Anxiety, PTSD
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
RESYNC-BH is a research study evaluating a personalized, non-drug brain-and-body treatment approach for adults with ongoing behavioral health symptoms such as depression, anxiety, trauma-related symptoms, sleep problems…
- Conditions
- Anxiety, PTSD, ADHD, Depression Disorders
- Trial name
- RESYNC-BH (NCT07812987)
- Testing
- AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Tactical Mind Research Coalition, Inc.
Neuropathic Pain
Improving Functions in Veterans With Post-traumatic Peripheral Neuropathic Pain
The proposed study will set the foundation for future multi-center studies. To validate tMS as a non-contact and non-invasive pain treatment option for reducing pain in Veterans with PTP-NP and improving their overall functions.
- Trial name
- PTP-NP (NCT02979925)
- Testing
- Active Transcutaneous Magnetic Stimulation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- VA Office of Research and Development
Traumatic Nerve Injury
A Comparative Post-marketing Study of Commercially Available Peripheral Nerve Gap Repair Options
This study is a comparison of sensory recovery outcomes following the use of AVANCE Nerve Graft or hollow tube conduit for peripheral nerve gap repairs in the hand.
- Trial name
- CHANGE (NCT00948025)
- Testing
- Hollow tube nerve conduit, synthetic or biosynthetic, Processed Human Nerve Tissue
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Axogen Corporation