Clinical trials: Traumatic Nerve Injury
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Concussion, Mild, Convergence Insufficiency
Effect of Vergence Exercises for Patients With Convergence Insufficiency After Concussion.
A large proportion of concussion patients with long-term consequences of concussion experience visually related symptoms such as headache, blurred vision, double vision, and fatigue.
- Trial name
- NCT05012384
- Testing
- Vergence exercises (Orthoptic exercises)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Danish College of Optometry and Vision Science
PTSD, Post Traumatic Stress Disorder
Targeted Plasticity Therapy for PTSD
Objectives of this study are to provide continued safety assessment for the ReStore system, and to gain further estimates of the effect size of Vagus Nerve Stimulation (VNS) therapy with Prolonged Exposure Therapy (PE) compared…
- Trial name
- NCT06266364
- Testing
- Active VNS stimulation
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC
Fibromyalgia (FM) pain and PTSD are highly prevalent and comorbid with associated increased risk of negative physical and mental health outcomes, including higher risk for opioid use and suicide.
- Trial name
- SWIFT-RELIEVE (NCT07718984)
- Testing
- tAN plus PEPC
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Traumatic Optic Neuropathy
Surgery for Traumatic Optic Neuropathy
The pathophysiology of Traumatic Optic Neuropathy (TON) include a primary and secondary mechanism of injury. At present, no studies validate a particular approach to the management of TON.
- Trial name
- NCT02711982
- Testing
- Optic canal and optic nerve sheath decompression, methylprednisolone
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Shanghai Changzheng Hospital
PTSD, Sleep Disturbance
Electrical Vestibular Nerve Stimulation (VeNS) as a Method of Sleep Management in People With PTSD
This double blind randomized controlled study will enroll 20 subjects and will be conducted remotely. The study will be randomized for an 8-week period with a 1:1 active to sham device allocation.
- Conditions
- PTSD, Sleep Disturbance, Insomnia
- Trial name
- NCT04780893
- Testing
- Modius Sleep
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Stress Disorders, Post-Traumatic
taVNS to Reduce PTSD Symptoms in WTC Responders
This study seeks to conduct a randomized, double-blind pilot study, to determine whether the Transcutaneous Auricular Vagus Nerve Stimulation and study procedure are feasible and acceptable for use with World Trade Center…
- Trial name
- taVNS (NCT05212714)
- Testing
- taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
TBI (Traumatic Brain Injury)
Asia Coma Electrical Stimulation (the ACES Trial)
This study is a prospective multicenter randomized controlled trial from Asian countries to compare the effect and safety of right median nerve stimulation versus traditional treatment for comatose patients at the early stage…
- Trial name
- ACES (NCT02645578)
- Testing
- Right median nerve stimulation
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Spinal Cord Injury, Acute, Neurogenic Bladder
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
- Trial name
- NCT03083366
- Testing
- PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase
Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography
The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter Measurement
- Trial name
- MHTS-ONSD (NCT07786324)
- Testing
- Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hip Fractures, Acute Pain
PENG Block for Traumatic Hip Fracture in the Emergency Department
The study is a multicenter single-blinded randomized comparative trial. Adult patients older than 20 years of age presenting with acute hip fracture in emergency department between January 1st, 2021 and December 31st, 2021 will…
- Conditions
- Hip Fractures, Acute Pain, Emergency Department
- Trial name
- NCT04997785
- Testing
- Ultrasound-guided Pericapsular Nerve Group (PENG) Block
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Dalin Tzu Chi General Hospital
Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED Bundle
The design of the present study will be a multicenter prospective observational protocol. Approximately 100 patients will be recruited over the 24-month period with Acute Brain Injury (trauma brain injury, intracerebral…
- Conditions
- Intra Cerebral Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Trauma, Brain, Hypertension Intracranial
- Trial name
- CLOSED (NCT06057155)
- Testing
- ultrasound optic nerve sheath diameter assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Traumatic Optic Neuropathy
Targeted Shortwave Diathermy Combined With Perceptual Training for Patients With Severe Traumatic Optic Neuropathy
Purpose: Patients with severe traumatic optic neuropathy (TON) have limited improvement in visual function despite therapy. The hypothesis of the study is that the targeted shortwave diathermy combined with perceptual training…
- Trial name
- NCT05140486
- Testing
- Rehabilitation: shortwave diathermy and perceptual training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hunan Provincial People's Hospital
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Subdural Hematoma, Anesthesia
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for…
- Trial name
- NCT05888389
- Testing
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Depression, Post-traumatic Stress Disorder
Trigeminal Nerve Stimulation for Post Traumatic Stress Disorder (PTSD) and Depression
This is a 20-subject, dose finding study to examine the use of external trigeminal nerve stimulation (TNS) as an adjunctive treatment for adults with major depressive disorder (MDD) co- occurring with posttraumatic stress…
- Trial name
- NCT01335217
- Testing
- Transcutaneous Electrical Nerve Stimulator (TENS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Cognitive Dysfunction
Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patients With Acute Traumatic Brain Injury
Currently, the treatment of cognitive dysfunction after acute TBI remains a challenge, and novel therapeutic methods are urgently needed.
- Trial name
- MARS-TBI (NCT07413562)
- Testing
- Median nerve stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Mild Traumatic Brain Injury, Brain Concussion
Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
The purpose of this single center, longitudinal, pilot study is to provide evidence for the use of an eye tracking system as an objective tool to identify mild traumatic brain injury (mTBI) related oculomotor dysfunction (OMD)…
- Conditions
- Mild Traumatic Brain Injury, Brain Concussion, Convergence Insufficiency, Accommodative Insufficiency
- Trial name
- NCT03319966
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Hennepin Healthcare Research Institute
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
Convergence Insufficiency
Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI
The design of this project is a pilot study, a type of feasibility study conducted in preparation for subsequent RCTs that will assess the effectiveness of office-based vergence/accommodative therapy with movement (OBVAM) for…
- Trial name
- TBEye (NCT06848673)
- Testing
- Office-Based Vergence/Accommodative Therapy with Movement (OBVAM)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salus University