Clinical trials: Travelers' Diarrhea
Enterotoxigenic E. Coli (ETEC) Infection
ACE527 Safety and Immunogenicity Study
The purpose of this study is to evaluate the safety and immune response to ACE527.
- Trial name
- NCT00901654
- Testing
- ACE527 vaccine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TD Vaccines A/S
Antibiotic Resistant Infection, Antibiotic Resistant Strain
ESBL in Patients Returning to Sweden With Traveller's Diarrhoea
Patients with traveller's diarrhoea frequently harbour Extended Spectrum Betalactamase (ESBL)-producing Enterobacteriaceae (EPE) returning from EPE-endemic areas.
- Conditions
- Antibiotic Resistant Infection, Antibiotic Resistant Strain, Traveler's Diarrhea
- Trial name
- NCT03866291
- Testing
- No intervention, observational
- Where
- Sweden
- Volunteers
- 305 people
- Sponsor
- Lund University
Diarrhea
Safety and Immunogenicity Study of Traveler's Diarrhea Vaccine Patch
The purpose of this study is to evaluate and compare the safety and immune responses following a two vaccination regimen by transcutaneous immunization with heat-labile enterotoxin of E.
- Trial name
- NCT01067781
- Testing
- Heat-Labile Enterotoxin of E. coli (LT)
- Where
- 5 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Traveler's Diarrhoea
Etiological Diagnosis of Traveler's Diarrhoea
Traveler's diarrhoea or turista is the most common disease in travelers. It has been reported based on studies in 20 to 60% of travelers, depending among other conditions and travel destinations.
- Trial name
- DIAVOY (NCT02866201)
- Testing
- Rectal swab
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diarrhea
Rifaximin Versus Placebo in the Prevention of Travelers' Diarrhea
The purpose of this study is to evaluate the effectiveness of poorly absorbed rifaximin in the prevention of travelers' diarrhea among U.S. college students in Mexico for five weeks.
- Trial name
- NCT00098384
- Testing
- rifaximin
- Where
- Mexico
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- DuPont, Hurbert L., MD
Diarrhea
Rifaximin for Prevention of Travellers' Diarrhea
The purpose of this study is to determine if 600 mg of rifaximin, taken once a day for 14 days by healthy subjects, is safe and effective for the prevention of travellers' diarrhea compared to placebo.
- Trial name
- NCT00742469
- Testing
- Rifaximin
- Where
- Mexico
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Prevention of Travelers' Diarrhea
LT Vaccine Patch Self-Administration Study
To evaluate the immune responses achieved following self-administered heat-labile enterotoxin of E. coli (LT) vaccination by transcutaneous immunization compared to the immune responses achieved by clinician-administered…
- Trial name
- NCT00565461
- Testing
- heat-labile enterotoxin of E. coli (LT)
- Where
- 3 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Travelers' Diarrhea
Travelers' Diarrhea (TD) Vaccine Pivotal Efficacy Study
The purpose of this study is to evaluate the efficacy of the Travelers' Diarrhea Vaccine System to actively immunize against Enterotoxigenic Escherichia coli disease in a field setting.
- Trial name
- NCT00993681
- Testing
- TD Vaccine System
- Where
- 20 sites in Germany, Guatemala and 2 more
- Volunteers
- 2,036 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Gastroenteritis in Adult Travelers
Safety and Efficacy of Prulifloxacin Versus Placebo in Traveler's Diarrhea
The objective of this pivotal Phase III study is to investigate the safety and efficacy of prulifloxacin versus placebo in the treatment of subjects with acute bacterial gastroenteritis.
- Trial name
- NCT00392574
- Testing
- Prulifloxacin
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- Merck Sharp & Dohme LLC
Diarrhoea
Prophylactic Treatment of Travellers' Diarrhoea With Rifaximin
The aim of the study is to investigate the efficacy of the prophylactic treatment with rifaximin to prevent travellers diarrhoea.
- Trial name
- NCT00979056
- Testing
- Rifaximin, Lactose
- Where
- Germany
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Dr. Philipp Zanger, MD MSc DTM
Travelers' Diarrhea
Dose-Finding Study of WS6788A and LSN03-016011/A Enterotoxigenic E. Coli ETEC Challenge Strains That Express CS17
This will be a strain and dose-finding study in which LSN03-016011/A ETEC will be administered at a starting inoculum of 5x108 cfu to 5 subjects to establish a human disease model.
- Trial name
- NCT00564577
- Testing
- CFA/I and CS17 challenge strain
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Prevention of Travelers' Diarrhea
Traveler's Diarrhea (TD) Automated Process
To evaluate and compare the immune responses and safety following a two vaccination regimen by transcutaneous immunization with heat-labile enterotoxin of E. coli (LT) patches or placebo patches.
- Trial name
- NCT00751777
- Testing
- heat-labile enterotoxin of E. coli (LT)
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Travel Medicine
French Travelers' Knowledge of Risk of Acquiring ESBL-PE
Since it is not routine practice in France to raise public awareness about the risk of acquiring multidrug resistant Enterobacteriaceae (MRE) during international travel, the investigators aimed to determine, among French…
- Trial name
- MDR bacteria (NCT03339947)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 191 people
- Sponsor
- CHU de Reims
Campylobacter Infection
ACE393-103 Vaccination Challenge Study
The purpose of this study is to determine whether ACE393 vaccination can protect against Campylobacteriosis in a challenge model.
- Trial name
- ACE393-103VC (NCT00859716)
- Testing
- ACE393
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TD Vaccines A/S
Traveler's Diarrhea
Clinical Trial of CBS-2004 in Prevention of Travelers' Diarrhea
This study is designed as a randomized double-blinded treatment trial among travelers' to geographical areas with moderate-severe rates of traveler's diarrhea.
- Trial name
- NCT02736539
- Testing
- CBS 2004 (galacto-oligosaccharides)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Clasado Biosciences Ltd
Diarrhea
Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
This is a Phase II b, double-blind, randomized, placebo-controlled study in healthy adults (age 18-65 years) to evaluate the safety, immunogenicity, different diagnostic tools and efficacy of ETVAX.
- Trial name
- NCT03729219
- Testing
- E. coli ETVAX
- Where
- Finland
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Scandinavian Biopharma AB
Diarrhea
ETEC Logistics Trial (TREK)
This is a multicenter, double-blind, randomized, placebo-controlled field trial to evaluate the epidemiology of natural infection with ETEC occurring after transcutaneous immunization in a field setting.
- Trial name
- Trek (NCT00516659)
- Testing
- Heat-Labile Enterotoxin of Escherichia coli (LT)
- Where
- 19 sites in United States, Guatemala and 1 more
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Diarrhea
Prevention of Traveler's Diarrhea
The prevention of traveller's diarrhea makes use of the selection of foods and drinks, the purification of water, the use of pharmacological substances such as bismuth salicylate and rifaximin (which can only be taken for short…
- Trial name
- NCT06125626
- Testing
- Probiotical
- Where
- Italy
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Diarrhea
Study Comparing Rifaximin With Xifaxan 200 mg in Traveler's Diarrhea
The primary objective is to demonstrate rifaximin 200 milligrams (mg) tablets (test) and Xifaxan® 200 mg tablets (reference) are clinically bioequivalent with respect to the clinical cure rates when administered 3 times a day…
- Trial name
- NCT02498418
- Testing
- Rifaximin, Xifaxan®
- Where
- United States
- Volunteers
- 739 people
- Sponsor
- Actavis Inc.