Clinical trials: Treatment Efficacy
Parkinson Disease, Tremor
Action Observation Therapy and Mirror Therapy in Parkinson's Disease
Small muscles of the hand are affected due to involuntary movements and slowing of voluntary movements seen in Parkinson's disease. There is a loss of fine dexterity and coordination in the hand.
- Trial name
- NCT05350709
- Testing
- mirror therapy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Gingivitis, Plaque
Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a positive control mouth rinse and a hydroalcohol control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT04921371
- Testing
- Colgate® Cavity Protection Toothpaste, Listerine® Cool Mint®, Concept Curve Winter Series Toothbrush
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Psoriasis
Study of a New Dressing for Use With Topical Medications
The purpose of this study is to determine if a new dressing designed to be used with topical medications will enhance the effects of these topical medications.
- Trial name
- NCT00234728
- Testing
- Occlusive dressing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Teikoku Pharma USA, Inc.
Hemophilia A
Phase 3 Study for Efficacy and Safety Outcomes Data in Japanese Patients With Severe Hemophilia A
This Phase III clinical study will evaluate the safety and effectiveness of valoctocogene roxaparvovec in Japanese patients with severe hemophilia A.
- Trial name
- GENEr8-JPN (NCT06224907)
- Testing
- Valoctocogene roxaparvovec
- Where
- 4 sites in Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BioMarin Pharmaceutical
Digestive System Disorders
Protocol: Phytomedicine-AMARGOL®, Clinical Trial for Efficacy Proof on Therapeutics
This is a Phase 3: Efficacy Study for AMARGOL® a phytomedicine used for asymptomatic digestive complaints.
- Trial name
- AMARGOL (NCT01485328)
- Testing
- AMARGOL®
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laboratorio Saude Ltda.
Dental Caries
Occlusal ART Restorations in Primary Molars Using 3 Different GIC
The aim of this study is to evaluate the survival rate and the cost-effectiveness of occlusal-ART restorations using three GIC brands (Fuji IX, GC Europe; Maxxion R, FGM; Vitro Molar, DFL) in primary molars.
- Trial name
- NCT02377297
- Testing
- Restoration with Fuji IX, Restoration with Vitro Molar, Restoration with Maxxion R
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Prolonged Grief Disorder (PGD)
Technology-supported Interventions for Prolonged Grief Disorder (PGD)
The main aim of this project is to test the efficacy of two formats of delivering an internet- based treatment(GROw) for Prolonged Grief Disorder (PGD) in order to enhance treatment adherence: in a blended format (that combines…
- Trial name
- NCT06932120
- Testing
- Internet-based treatment (GROw) combined with face-to-face videoconferencing sessions with a therapist in BF-GROw group, Internet-based treatment (GROw) supported by the App developed which contains the EMA and EMI tools in iGROw group.
- Where
- 2 sites in Spain
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Chronic Interstitial Cystitis
Pentosan Polysulfate Treatment's Effectiveness
To examine the relationship between symptoms and quality of life before and after oral pentosan polysulfate (PPS) treatment in cases diagnosed with interstitial cystitis/painful bladder syndrome (IC/BPS).
- Trial name
- NCT05744908
- Testing
- Pentosan Polysulphate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Psychological Resilience, Family Functioning
Does Group Therapy Improve Resilience and Family Functioning Among Mothers of Children With Intellectual Disabilities?
Abstract This study examined the effectiveness of a seven-week structured group therapy intervention designed to enhance the psychological resilience and family functioning of mothers of children with intellectual disabilities.
- Trial name
- NCT07738289
- Testing
- Structured Group Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sinop University
Mandibular Nerve, Mandibular Nerve Blocks
Comparative Assessment of Mental/Incisive and Inferior Alveolar Nerve Block Anesthesia in Root Canal Treatment of Mandibular Premolars
The goal of this clinical trial is to systematically compare the pain scores and anesthesia efficacy of IANB and MNB in the treatment of symptomatic mandibular first and second premolars.
- Conditions
- Mandibular Nerve, Mandibular Nerve Blocks, Premolars, Mental Nerve Block
- Trial name
- NCT06679660
- Testing
- inferior alveolar nerve block with 4% articaine, Mental/Incisive Nerve Block (%4 Articaine)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney
Effectiveness of Thread Embedding Acupuncture Analgesia at the EX-B2 Point Combined With Standard Therapy After Laparoscopic Living Donor Nephrectomy
Kidney transplantation is the main option besides hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) to prolong and improve the quality of life for patients with end-stage renal disease.
- Conditions
- Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney, Quality of Life, Acupuncture Analgesia
- Trial name
- NCT06197620
- Testing
- Thread embedding acupuncture and standard therapy
- Where
- Indonesia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Malaria
Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal
In areas of seasonal malaria transmission the burden of severe disease and mortality due to malaria is mainly among children under 5 years of age.
- Trial name
- NCT00712374
- Testing
- sulfadoxine-pyrimethamine plus amodiaquine
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Urology
Efficacy and Safety of Two Bladder-preserving Treatment Durations With Disitamab Vedotin Plus Toripalimab Combination in Her2-expressing Muscle-invasive Bladder Cancer: A Phase II, Open-Label, Randomized Clinical Trial
This study aims to evaluate the efficacy of disitamab vedotin combined with toripalimab as a bladder-preserving treatment combination in patients with HER2 positive locally advanced MIBC, including one year bladder-intact DFS…
- Trial name
- NCT07151560
- Testing
- 6 cycle RC48 and JS001, 12 cycle RC48 and JS001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Iron Deficiency Anemia of Pregnancy
Iron Infusion Into a Vein Compared to Iron Tablet Taken by Mouth for Treating Iron Deficiency Anemia in Pregnancy (IVON)
Background: Anaemia in pregnancy is a public health burden with high incidence in Africa. Currently high dose oral iron is recommended for treatment of mild to moderate anaemia and blood transfusion for severe anaemia.
- Trial name
- IVON (NCT04976179)
- Testing
- Ferric carboxymaltose, Ferrous sulfate
- Where
- 11 sites in Nigeria
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- University of Lagos, Nigeria
Snake Bites
Safety and Effectiveness of PANAF-Premium TM Snake Venom Antiserum As Standard Treatment for Snakebites
Snakebite envenomation (SBE) is a major public health problem in many developing countries. Standard snake antivenom (SA) remains the primary treatment and has been shown to reduce mortality in observational studies conducted in…
- Trial name
- PMS (NCT06615960)
- Where
- Cameroon
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Premium Serums & Vaccines Pvt.Ltd.
Periodontitis
Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:
To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis
- Trial name
- resveratrol (NCT05874882)
- Testing
- resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients, chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Femoral Shaft Fracture, Pediatric ALL
Femoral Pediatric Fractures. Walking Spica Cast vs Synthetic Pants
Femoral pediatric shaft fractures are a common orthopedic injury. Conservative treatment is still the preferred method by orthopedic surgeons.
- Trial name
- NCT04311866
- Testing
- Synthetic pants, Spica cast
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Acute Mountain Sickness (AMS)
Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
The specific aim of this double blind, randomized phase III trial is to evaluate the safety and efficacy of T89 in preventing Acute Mountain Sickness (AMS) and relieving the symptoms of AMS after rapid ascent.
- Trial name
- NCT04993729
- Testing
- T89 capsule
- Where
- 3 sites in United States, China
- Volunteers
- 853 people, healthy volunteers welcome
- Sponsor
- Tasly Pharmaceuticals, Inc.
Obesity, Weight Loss
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis
Obesity is an epidemic in the US. With progression of obesity, Nonalcoholic steatohepatitis (NASH) has been a growing public health issue.
- Conditions
- Obesity, Weight Loss, Body Weight, Nonalcoholic Steatohepatitis
- Trial name
- NCT02933554
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Keith Pereira, MD:
Hypersensitivity
Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction
Tooth sensitivity reduction after dentifrices use
- Trial name
- Yeaple (NCT01040169)
- Testing
- Arginine/Calcium Carbonate, Mint Prophy paste - Fluoride free
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
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