Clinical trials: Treatment Of Obesity
Breast Cancer, Primary Hormone Receptor Positive Breast Cancer
A Study of the Body's Response to Exercise and a Plant-Based Diet in Overweight Postmenopausal Women With Breast Cancer
The purpose of this study is to find out what effects, if any, exercise and a plant-based diet have on aromatase levels in postmenopausal women who are overweight and being treated with an aromatase inhibitor for their HR+ breast…
- Trial name
- NCT04298086
- Testing
- Exercise Treatment, Plant-Based Diet, Physical activity
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity
Autophagy and Inflammasome in Obesity: Effect of Weight Loss and Potential Therapeutic Implications
The main aim of this project is to determine the implication of autophagy and inflammasome in the pathogenesis of obesity and related comorbidities, and to explore in depth the mechanisms associated with the activation of immune…
- Trial name
- NCT05071391
- Testing
- Roux-en-Y gastric bypass
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Milagros Rocha Barajas
Type 2 Diabetes Mellitus
Study of Immune Cells in Obese Patients With Type 2 Diabetes Mellitus Treated With Liraglutide
The purpose of this study is to determine the effect of exogenous glucagon-like peptide-1 on the immune system i.e on the regulation of immune cells important in diseases such as obesity and diabetes.
- Trial name
- NCT02201550
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Glucagon-Like Peptide-1 Receptor Agonists
HDM1002 Tablets in Chinese Overweight and Obese Adult Subjects
To assess the safety of multiple oral doses of HDM1002 tablets under different titrations in Chinese overweight and obese adult subjects.
- Trial name
- NCT06520540
- Testing
- HDM1002 100 mg QD 12weeks, HDM1002 200 mg QD 12weeks, HDM1002 400 mg QD 12weeks，Q 2W for titration
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Fatty Liver Disease, Obesity
Effect of Lyophilized Cornus Mas L. on Anthropometric and Biochemical Parameters in Metabolic Associated Fatty Liver Disease Patients
The aim of the study was to evaluate the effect of lyophilized Cornus mas L. fruit powder with/without diet therapy on biochemical parameters and anthropometric measurements in patients with metabolic associated fatty liver…
- Conditions
- Fatty Liver Disease, Obesity, Liver Fat
- Trial name
- NCT05546450
- Testing
- Diet, Cornus mas L.(Cornelian Cherry)
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Istanbul Gelisim University
Overweight, Obesity
RCT to Compare Orlistat and Polyglucosamine for the Management of Overweight and Obesity
This trial compares two treatment methods: 1. Orlistat 60 mg to be taken three times daily one capsule; indicated for weight loss in overweight adults.
- Trial name
- NCT02529631
- Testing
- orlistat 60 mg, polyglucosamine
- Where
- 2 sites in Germany, Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Certmedica International GmbH
Obesity, Poor Glycemic Control
The Consumption of Beef on Appetite and Cognitive Function
The purpose of the main study is to determine whether the daily consumption of protein-rich meals containing high quality, lean beef products improves appetite control and cognitive function during a weight maintenance diet.
- Conditions
- Obesity, Poor Glycemic Control, Dietary Interventions
- Trial name
- NCT02614729
- Testing
- Standard Protein-Plant, Even Distribution (SP-PLANT-EVEN), Standard Protein-Beef, Even Distribution (SP-BEEF-EVEN), High Protein-Beef, Even Distribution (HP-BEEF-EVEN)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity
Diastolic Dysfunction During Conservative Lifestyle Treatment
The Purpose of this study is to 1) investigate prevalence of diastolic dysfunction in patients with morbid obesity attending a conservative lifestyle change program, 2) investigate effects on cardiac function, cardiorespiratory…
- Trial name
- NCT02826122
- Testing
- Pai APP, FitBit APP
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- Norwegian University of Science and Technology
Eating Disorders, Binge-Eating Disorder
The Effects of Nutritional Intervention in Participants With Eating Disorders.
The goal of this clinical trial is to evaluate the effects of nutritional intervention in eating disorders. Participants underwent an intervention without a control group over 8 weeks.
- Conditions
- Eating Disorders, Binge-Eating Disorder, Binge Eating Disorder Associated With Obesity, Eating Behavior
- Trial name
- NCT06230107
- Testing
- Mindful Eating
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Obesity, Weight Gain
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition and physical activity in adolescents with obesity and multiple weight related…
- Trial name
- NCT06439277
- Testing
- Tirzepatide
- Where
- 69 sites in United States, Argentina and 10 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Hormone Receptor-Positive Breast Cancer
Estradiol Levels According to Body Mass Index in Premenopausal Patients With Breast Cancer
his prospective observational study will evaluate whether body mass index (BMI) is associated with serum estradiol levels in premenopausal women with hormone receptor-positive breast cancer.
- Trial name
- SIMPEC-E2 (NCT07833501)
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- D'Or Institute for Research and Education
Obesity, Abdominal Obesity
Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals
Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.
- Trial name
- KOBI (NCT05428137)
- Testing
- Probiotic, Postbiotic
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Obesity (BMI>30)
Resistance Training to Prevent Muscle Loss During Treatment With Tirzepatide
Incretin-based pharmacotherapies induce significant weight loss and represent a paradigm shift in obesity treatment. However, particularly fast weight loss may be accompanied by a significant loss of muscle mass, which is…
- Trial name
- RESIST (NCT07777575)
- Testing
- Dual GIP/GLP-1 Receptor Agonist Tirzepatide, Resistance Training
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Overweight, Childhood, Obesity Prevention
High Five! - School-based Prevention of Overweight and Obesity Among 6 to 9 Year Olds
The goal of this interventional study is to assess the effectiveness of the school-based "High Five!" program in reducing overweight, obesity and high blood pressure in children aged 7-9 years old.
- Conditions
- Overweight, Childhood, Obesity Prevention, Blood Pressure
- Trial name
- DINO-PL (NCT07357857)
- Testing
- High Five
- Where
- Poland
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Fatty Liver, Hepatitis
Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH)
The purpose of this study is to determine if orlistat (Xenical) therapy in overweight patients with NASH leads to enhanced weight loss over time, with subsequent improvement in the underlying necroinflammatory and fibrotic…
- Trial name
- NCT00160407
- Testing
- Orlistat (Xenical), 1400 kcal diet (30% fat)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Louis University
Diabetes Mellitus, Type 2, PreDiabetes
Mastering Diabetes Study
This is a program evaluation that will evaluate the effectiveness of Mastering Diabetes, a therapeutic lifestyle change (TLC) program to control prediabetes and type 2 diabetes.
- Trial name
- NCT04454957
- Testing
- Mastering Diabetes
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Ohio University
Body Weight Changes, Human Immunodeficiency Virus
Doravirine and Weight Gain in Antiretroviral Naive
The purpose of this study is determine whether different antiretroviral therapy (ART) changes the effects on body fat and predict the weight change in Black and Hispanic females.
- Conditions
- Body Weight Changes, Human Immunodeficiency Virus, ART, Obesity
- Trial name
- DAWN (NCT05457530)
- Testing
- DOR/3TC/TDF, DOR + FTC/TAF, BIC/FTC/TAF
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Prism Health North Texas
Community-Based Participatory Research
Evaluating Family & Community-Based Interventions to Improve Treatment Adherence in Metabolic Health Among Negev Bedouins (EFIT-BED)
Background: The Bedouin community in the Negev faces high rates of type 2 diabetes, low treatment adherence, and increased disease complications.
- Trial name
- EFIT-BED (NCT06575465)
- Testing
- Healthy lifestyle nutrition, culture and physical activity workshops, Usual care
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ariel University
Glucose Metabolism Disorders, Diabetes Mellitus, Type 2
Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4…
- Conditions
- Glucose Metabolism Disorders, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Empagliflozin
- Trial name
- NCT06145360
- Testing
- Empagliflozin 10 MG, Insulin+Metformin+DPP4 inhibitor (DPP4I)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- SINA Health Education and Welfare Trust
Prader-Willi Syndrome, Hyperphagia
Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome
This study is a phase 2 randomized double blind 8-week treatment trial of intranasal OXT vs. placebo in 50 subjects aged 5 to 17 years with PWS in order to assess IN-OXT's affect on measurements of (1) eating behaviors (2)…
- Trial name
- NCT03197662
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Eric Hollander
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.