Clinical trials: Treatment Of Obesity
Morbid Obesity, Perioperative Hemorrhage
Effect of Tranexamic Acid on Bleeding After Bariatric Surgery
Postoperative bleeding is an important complication of bariatric surgery and may lead to increased morbidity, prolonged hospitalization, and higher healthcare costs.
- Conditions
- Morbid Obesity, Perioperative Hemorrhage, Obesity, Tranexamic Acid
- Trial name
- TXA-BARI (NCT07754396)
- Where
- Greece
- Volunteers
- 140 people
- Sponsor
- G.Gennimatas General Hospital
Hyperphagia, Prader-Willi Syndrome
ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial
The goal of this clinical trial is to learn if ARD-101 works to treat hyperphagia-related behavior in patients with Prader-Willi syndrome (PWS). It will also teach us about the safety of ARD-101.
- Trial name
- HERO (NCT06828861)
- Testing
- ARD-101
- Where
- 31 sites in United States, Australia and 3 more
- Volunteers
- 68 people
- Sponsor
- Aardvark Therapeutics, Inc.
Obesity
A Study to Investigate the Safety, Tolerability, Pharmacokinetic/Pharmacodynamic Characteristics, and Food Effect of HSG4112
1. Study Objective: The objective of this phase 1 clinical trial is to evaluate the safety, tolerability, pharmacokinetic/pharmacodynamic characteristics and food effect of HSG4112 after oral administration in healthy male…
- Trial name
- NCT04732988
- Testing
- HSG4112
- Where
- 2 sites in South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Glaceum
Obesity, Visceral, Obesity; Endocrine
Study of Lipolysis of Visceral Reserve Fat Using Tecar Therapy.
The Scope of this study is to assess the visceral and subcutaneous fat loss in patients having Tecar (Radiofrequency) Therapy and its effects on other anthropometric variables, adipokines and inflammation.
- Trial name
- NCT06377358
- Testing
- Tecar Therapy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CAPENERGY MEDICAL, SL
Childhood Obesity
Gardner Packard Healthy Lifestyles Program
Gardner GOALS is a 6 month program for treatment of childhood obesity that consists of twice monthly telehealth meetings with a health educator.
- Trial name
- NCT05107648
- Testing
- Gardner GOALS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
Type 2 Diabetes
Treatment With Sitagliptin in Non-obese Japanese Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) results from early phase insulin secretory defect and insulin resistance. Studies have shown that most of the populations in which insulin resistance is considered to be the primary pathogenetic…
- Trial name
- NCT01642108
- Testing
- Sitagliptin
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Niigata Medical Center
Hypoglycemia, Obesity, Morbid
The Effect of 'Medical Nutrition Therapy' on Post-bariatric Hypoglycemia 2-4 Years After Gastric Bypass Surgery
This is a pilot study to explore the effect of 'medical nutritional therapy' in patients diagnosed with post-bariatric hypoglycemia (PBH), 2-4 years after gastric bypass surgery.
- Trial name
- NCT05011682
- Testing
- Regular diet, 10-point nutrition plan
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Helse Nord-Trøndelag HF
Obesity, Vitamin D Deficiency
Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients
As the use of bariatric surgery for treatment of extreme obesity adults continues to rise, clinicians must be aware of pre-existing nutritional deficiencies in overweight and obese patients.
- Trial name
- NCT01385098
- Testing
- Vitamin D3 and Calcium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vadim Sherman, MD
Obesity
Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery.
- Trial name
- NCT01845363
- Testing
- Cefazolin used in antimicrobial prophylaxis
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Federal de Pernambuco
Obesity
Behavior Therapy Prior to Bariatric Surgery
Obesity is an ever increasing public health problem in this country. Bariatric surgery is currently the most effective treatment for morbid obesity and two hundred thousand surgeries are performed in the United States each year.
- Trial name
- NCT01125397
- Testing
- LEARN group
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Obesity
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss.
- Trial name
- TRIUMPH-6 (NCT06859268)
- Testing
- Retatrutide
- Where
- 53 sites in United States, Canada and 1 more
- Volunteers
- 643 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients
Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disease, often compounded by obesity, that leads to serious long-term health complications.
- Trial name
- NCT07728318
- Testing
- Tirzepatide + Standard Therapy (Intervention Group), Standard Oral Antidiabetic Drugs (OADs)
- Volunteers
- 52 people
- Sponsor
- Akhtar Saeed Medical and Dental College
Binge-Eating Disorder
A Comparison of Methylphenidate and Cognitive Behavioural Therapy for the Treatment of Binge Eating Disorder
The purpose of this study is to determine whether methylphenidate is effective in the treatment of binge eating disorder, in a randomized controlled trial extended release methylphenidate versus cognitive behavioral therapy for…
- Trial name
- NCT01921582
- Testing
- Methylphenidate, Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Centre for Addiction and Mental Health
Type 2 Diabetes, Overweight
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Conditions
- Type 2 Diabetes, Overweight, ASCVD
- Trial name
- INTERCEPT (NCT07417618)
- Testing
- Dulaglutide, Semaglutide, Tirzepatide
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- Brigham and Women's Hospital
Obesity Type 2 Diabetes Mellitus
Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes
Investigation of the efficacy of fecal microbiota transplantation added to calorie-restricted diet and semaglutide versus calorie-restricted diet and semaglutide alone for weight loss and metabolic improvement in patients with…
- Trial name
- NCT07599046
- Testing
- Fecal microbiota transplantation (FMT), Semaglutide (1 Mg Dose), Calorie-restricted diet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Morbid Obesity, Diabetes
Prospective Comparison Between SADI-S and Gastric Bypass
Patients with BMI over 40 or with BMI over 35 and comorbidities are offered SADI-S with a variable limb length between 250 cm and 300 cm or gastric bypass.
- Trial name
- SADI-S-GB (NCT02768506)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital San Carlos, Madrid
Type 2 Diabetes Mellitus
Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients
It is well known that Long-term hyperglycemia (also known as glucose toxicity) contribute to impairment in islet β-cell function and development of insulin resistance.
- Trial name
- NCT01588743
- Testing
- insulin aspart
- Volunteers
- 130 people
- Sponsor
- Li Guangwei
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Overweight and Obesity
Effect Of Meal Frequency On Weight Loss And Body Composition Of Obese And Overweight Women
Studies showing the relationship between meal frequency, weight loss and anthropometric measurements are contradictory. This study is planned and conducted to observe the effects of meal frequency (3 meals+3 snacks vs 3 meals) on…
- Trial name
- NCT05581862
- Testing
- 3 meals+3 snacks, 3 meals
- Where
- Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Obesity, Morbid
Aspiration Therapy for Obese Adolescents
Interventional studies devoted to adolescents are relatively rare in the world. This has several reasons. Treatment and research on obesity are centered on advanced forms of obesity in adults, bearing in mind that social and…
- Trial name
- NCT03598920
- Testing
- AsspireAssist, Nutritional consulting
- Where
- 3 sites in Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Ostrava
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