Clinical trials: Treatment Resistant
Hyperglycaemia, Hypoglycaemia
Continuous Glucose Monitoring by Subcutaneous Measurement Compared to Frequent Point of Care Measurement by Accu Chek in Critically Ill Patients
The purpose of this study is to evaluate the accuracy and reliability of the continuous glucose monitoring system the FreeStyle Navigator® (Abbott, Diabetes Care) in critically ill patients by comparing subcutaneous measuring…
- Trial name
- RESCUEII (NCT01526044)
- Testing
- Freestyle Navigator
- Where
- Netherlands
- Volunteers
- 178 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Metastatic Castration-resistant Prostate Cancer
PRostate Olaparib Real World Evidence Study
This French non-interventional longitudinal multicenter cohort study is conducted to study the added value of olaparib in the treatment of patients with mCRPC in the real world setting in terms of treatment sequencing…
- Trial name
- PROWESs (NCT06031805)
- Where
- 39 sites in France
- Volunteers
- 159 people
- Sponsor
- AstraZeneca
Antibiotic Resistant Infection, Critical Illness
Bolus Versus Continuous Infusion of Meropenem
This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units.
- Trial name
- MERCY (NCT03452839)
- Testing
- Meropenem
- Where
- 26 sites in Croatia, Italy and 2 more
- Volunteers
- 607 people
- Sponsor
- Università Vita-Salute San Raffaele
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02189694
- Testing
- Single-hormone closed-loop strategy, Dual-hormone closed-loop strategy, Insulin pump therapy
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Non Alcoholic Fatty Liver Disease
The Effect of Oral β- Glucan Supplement on Appetite and Insulin Resistance in Non Alcoholic Fatty Liver Disease
The Objective of This Study is Evaluating the Effect of oral β- glucan Supplement on Anthropometric Measurements, Appetite, Insulin Resistance, Liver echogenicity and Enzymes in Non Alcoholic Fatty Liver Patients Treating with…
- Trial name
- NCT02178839
- Testing
- β- glucan, Maltodextrin
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- Urmia University of Medical Sciences
PTSD, Post Traumatic Stress Disorder, Adolescents
MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents
The primary objective of this study is to determine the safety and feasibility of 3,4-methylenedioxymethamphetamine (MDMA) -assisted psychotherapy to treat resistant post-traumatic stress disorder (PTSD).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Adolescents, Psychotherapy
- Trial name
- NCT06353282
- Testing
- MDMA, Psychotherapy
- Where
- United States
- Sponsor
- University of California, Los Angeles
Malaria, Falciparum
A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC)
This study is an open-label randomised trial comparing standard ACT treatment with matching triple artemisinin-based combination therapies (TACTs), evaluating efficacy in safety and tolerability.
- Trial name
- TRACII (NCT02453308)
- Testing
- ACT, TACT
- Where
- 20 sites in Bangladesh, Burma and 6 more
- Volunteers
- 1,110 people
- Sponsor
- University of Oxford
Obesity
The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity
The primary aim of the study is to investigate the efficacy of metformin and topiramate on second-generation antipsychotic-induced obesity. The secondary domain we look at is the adverse effects of both drugs.
- Trial name
- NCT01384279
- Testing
- metformin, topiramate
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Beitou Armed Forces Hospital, Taipei, Taiwan
Clozapine Resistant Schizophrenia
Vitamin D for Schizophrenia
Background: Despite improvements in medications, treatment delivery and rehabilitation, schizophrenia outcomes remain suboptimal. There are a proportion of 30-40% treatment-resistant schizophrenia patients.
- Trial name
- NCT01759485
- Testing
- Vitamin D3
- Where
- Israel
- Volunteers
- 47 people
- Sponsor
- Geha Mental Health Center
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Cancer
REACT - Resistance Exercise After Cancer Treatment
Resistance exercise has been shown to improve several important health variables after cancer and cancer related treatment, but unfortunately the adherence to resistance exercise is low.
- Trial name
- REACT (NCT07159815)
- Testing
- Digital follow-up, On-site follow-up, Resistance exercise
- Where
- 4 sites in Norway
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Inland Norway University of Applied Sciences
Metastatic Castration Resistant Prostate Cancer, 68Ga-PSMA PET/CT Positive
Radiometabolic Therapy (RMT) With 177Lu PSMA 617 in Advanced Castration Resistant Prostate Cancer (CRPC)
Radiometabolic Therapy (RMT) with 177Lu PSMA 617 in advanced castration resistant prostate cancer (CRPC): efficacy and toxicity evaluation
- Trial name
- LU-PSMA (NCT03454750)
- Testing
- 177Lu-PSMA
- Where
- Italy
- Volunteers
- 143 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Insulin Sensitivity, Type 2 Diabetes
Exercise and Diet in Type 2 Diabetic Women
The purpose of this study was to evaluate the effects of 12 weeks' increased daily physical activity versus diet restriction on regional fat distribution, insulin sensitivity and adipokines including retinol binding protein-4…
- Trial name
- NCT00763074
- Testing
- Standard life style modification for type 2 diabetes, Diet restriction, Exercise
- Volunteers
- 70 people
- Sponsor
- Eulji University Hospital
Metastatic Castration-resistant Prostate Cancer
Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to evaluate the efficacy and safety (including evaluating side effects) of combination of olaparib and abiraterone versus placebo and abiraterone in patients with metastatic castration-resistant…
- Trial name
- NCT03732820
- Testing
- olaparib, abiraterone acetate
- Where
- 132 sites in United States, Australia and 15 more
- Volunteers
- 895 people
- Sponsor
- AstraZeneca
Functional Bowel Disorders
Open Label Seroquel (Quetiapine) Study for Treatment Resistant Functional Bowel Disorder
Purpose: We are proposing to examine, via open label trial, the use of Seroquel® for patients with moderate to severe functional bowel symptoms who are not receiving adequate relief from their symptoms on their present regimen of…
- Trial name
- NCT00617396
- Testing
- Quetiapine (50 mg/day-100mg/day)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression
RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode
The study is a phase II, double-blind, randomized, placebo controlled, parallel, multicentric study in 110 patients with drug resistant depression.
- Trial name
- NCT03870776
- Testing
- MAP4343
- Where
- 10 sites in France
- Volunteers
- 126 people
- Sponsor
- Mapreg
Multi-Drug Resistant Nephrotic Syndrome, CAR-T Cell Therapy
Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cell Therapy in Patients With MDR-SRNS
This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-CD19 CAR-T cells in the treatment of patients with Multi-drug resistant SRNS
- Trial name
- NCT06842589
- Testing
- anti-CD19 CAR-T cells
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Obsessive-Compulsive Disorder (OCD)
DBS for Obsessive-Compulsive Disorder
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the alternative approach or a combination of the…
- Trial name
- DBS (NCT02773082)
- Testing
- Reclaim™ DBS Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Hepatitis C Virus
The Durability of Response and Persistence of Resistance to AbbVie's 2 Direct-acting Antiviral Agent (2D) Therapy in Japanese Subjects
This study seeks to assess the durability of response and persistence of resistance to ombitasvir/ paritaprevir/ritonavir in Japanese participants who enrolled in a Phase 2 or 3 clinical study with these agents for the treatment…
- Trial name
- NCT02581020
- Where
- 53 sites in Japan
- Volunteers
- 344 people
- Sponsor
- AbbVie
Ovarian Cancer, Carcinoma, Ovarian Epithelial
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation…
- Conditions
- Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
- Trial name
- NCT05116189
- Testing
- Pembrolizumab, Paclitaxel, Bevacizumab
- Where
- 187 sites in United States, Australia and 23 more
- Volunteers
- 643 people
- Sponsor
- Merck Sharp & Dohme LLC
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