Clinical trials: Treatment Resistant
HIV
Antiretroviral Resistance Detection by Ultrasensitive Pyrosequencing of the HIV-1 Genome and Virological Response to Antiretroviral Rescue Treatment
This study aims to analyze the association between the baseline detection of resistance mutations through Ultra deep Sequencing (UDS) and the virological outcome of salvage antiretroviral therapy, in comparison with conventional…
- Trial name
- NCT01346878
- Where
- 4 sites in Spain
- Volunteers
- 143 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Metastatic Malignant Solid Neoplasm, Radiotherapy
Intestinal Low Dose Radiotherapy Combined With Immunotherapy in Immune-resistant Metastatic Solid Tumors
Preclinical and clinical studies have shown that intestinal low dose radiotherapy (ILDR) can enhance antitumor immunity and response to immune checkpoint blockade (ICB).
- Conditions
- Metastatic Malignant Solid Neoplasm, Radiotherapy, Immune Checkpoint Blockade, Resistance to Immunotherapy
- Trial name
- ILDR-01 (NCT06076135)
- Testing
- Intestinal Low Dose Radiotherapy-1Gy, PD-1/PD-L1 Inhibitors
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chuangzhen Chen
Lung Cancer, TKI Resistance
A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody
Lung cancer is the second most common malignancy and mortality rate in the world. In the United States and Europe, approximately 10% to 15% of NSCLC patients have epidermal growth factor receptor (EGFR)-sensitive mutations, with…
- Conditions
- Lung Cancer, TKI Resistance, EGFR Sensitive Mutation, Anlotinib
- Trial name
- NCT06048315
- Testing
- Anlotinib, Penpulimab
- Volunteers
- 52 people
- Sponsor
- Degan Lu
Prostate Cancer, Castrate Resistant Prostate Cancer
Docetaxel Alone or in Combination With Enzalutamide for mCRPC Previously Treated With Abiraterone at mHSPC Stage
New androgen pathway targeting agents (ARTA), including Abiraterone acetate, Apalutamide and Enzalutamide, are approved and used in treatment of metastatic hormonal sensitive prostate cancer(mHSPC).
- Trial name
- NCT05627752
- Testing
- Enzalutamide 40 MG, Docetaxel injection
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Uveitis
Outcome of Treatment of Uveitis With Biologic Drugs in Resistant Cases Vogt-koyanagi-Harada Disease
Reviewing the characteristics of patients with uveitis caused by Vogt-Koyanagi-Harada Syndrome treated at Assiut University Hospital at the Department of Ophthalmology and Department of Rheumatology, Physical Medicine, and…
- Trial name
- NCT05349747
- Testing
- Biologic drugs
- Volunteers
- 50 people
- Sponsor
- Assiut University
Helicobacter Pylori Treatment Failure
High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection
No trial has examined the the efficacy of high dose amoxicillin based quadruple therapy as second-line treatment for Helicobacter pylori infection.
- Trial name
- NCT02175927
- Testing
- Lansoprazole, Bismuth Potassium Citrate, Metronidazole
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Endometriosis
Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy
This study aims to analyze the salivary miRNA specific for patients diagnosed with endometriosis, specifically evaluating the miRNA profile of patients who respond versus those who do not respond to progestin therapy.
- Trial name
- ENDOmiRNA (NCT06414720)
- Testing
- Dienogest 2 MG
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Udine
Coronary Artery Disease
The EFFect of hIgh Dose ClopIdogrel treatmENT in Patients With Clopidogrel Resistance
Continuing high dose clopidogrel treatment after elective PCI decreased adverse cardiac events in patients with clopidogrel resistance
- Trial name
- EFFICIENT (NCT01032668)
- Testing
- Clopidogrel
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Bursa Postgraduate Hospital
Clomiphene Citrate, Resistant Ovary Syndrome
Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate
This study evaluate the addition of PTX and ALA to clomiphene citrate in the treatment of polycystic ovary.
- Conditions
- Clomiphene Citrate, Resistant Ovary Syndrome, Polycystic Ovary Syndrome
- Trial name
- NCT05231980
- Testing
- Alpha lipoic acid (ALA), Pentoxifylline (PTX), Clomiphene Citrate
- Where
- 3 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Type 2 Diabetes, Endothelial Dysfunction
Endothelial Effects of Basal Insulin: Detemir Versus Glargine
Endothelial progenitor cell (EPC) level represents a surrogate marker of cardiovascular risk and an indicator of the ongoing vascular damage.
- Conditions
- Type 2 Diabetes, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT00699686
- Testing
- Glargine, Detemir
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Obesity & Overweight
EMS vs. Resistance Training in Overweight Women
This study aims to compare the effects of eight weeks of resistance training versus electrical muscle stimulation (EMS) on oxidative stress indicators and cellular health index in overweight and obese women aged 35-45 years.
- Trial name
- NCT07787286
- Testing
- Resistance Training, Electrical Muscle Stimulation, No Intervention
- Where
- Iran
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Hypertension, Resistant to Conventional Therapy
Resistant Hypertension and Physical Activity Performed in a Heated Pool
patients with resistant hypertension will be submitted to an exercise protocol in a heated pool for three months
- Trial name
- HAR (NCT01863082)
- Testing
- exercise
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Alzheimer s Disease, Alzheimer Blood Biomarkers
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease.
- Conditions
- Alzheimer s Disease, Alzheimer Blood Biomarkers, Insulin Sensitivity
- Trial name
- MIND-IT (NCT07265323)
- Testing
- Physiological Insulin Intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Pennington Biomedical Research Center
Major Depressive Disorder
Transcranial Direct Current Stimulation as an Augmenting Intervention for Major Depression
Transcranial direct current stimulation (tDCS) is a noninvasive method to activate or de-activate neurons in superficial regions of the brain through the induction of weak electric currents in the brain tissue delivered by two…
- Trial name
- NCT01450150
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Douglas Mental Health University Institute
Hepatitis C
Dose Escalation Study of IL-7 and Bi-therapy in HCV Patients Resistant After 12 Weeks of Bi-therapy (ECLIPSE 1)
This study will evaluate the safety of a new experimental drug, IL-7, in people with HCV infection resistant after 12 weeks of bi-therapy.
- Trial name
- ECLIPSE 1 (NCT01025596)
- Testing
- Interleukin-7
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 10 people
- Sponsor
- Cytheris SA
Psoriasis
Pioglitazone in Psoriasis- A Clinical and Molecular Study.
The study will assess the effectiveness of Pioglitazone on cellular and clinical levels in terms of improvement of both skin and systemic manifestations of psoriasis.
- Trial name
- NCT01133561
- Testing
- actozone A, actozone B
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Epilepsy, Cryptogenic, Epilepsy, Partial
IVIG Treatment for Refractory Immune-Related Adult Epilepsy
The purpose of the initial screening study is to find out if immune problems are an unrecognized cause of epilepsy in some patients.
- Conditions
- Epilepsy, Cryptogenic, Epilepsy, Partial, Seizure Disorder, Autoimmune Diseases, Nervous System
- Trial name
- NCT01545518
- Testing
- IVIG
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Hypertension, Metabolic Syndrome
Evaluation of the Integrated Radio Frequency Denervation System for the Treatment of Hypertension
The objective of the study is to evaluate the safety of renal denervation using the iRF System and to understand any potential improvement in hypertension.
- Trial name
- RADAR (NCT04740723)
- Testing
- iRF System Renal Denervation
- Where
- 2 sites in Georgia
- Volunteers
- 30 people
- Sponsor
- Metavention
Treatment-Resistant Hypertension
Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension
This application proposes to extend an ongoing NHLBI clinical trial (NCT02342808) examining the efficacy of a lifestyle intervention combining the Dietary Approaches to Stop Hypertension (DASH) diet with caloric restriction and…
- Trial name
- NCT03001427
- Testing
- Structured center-based lifestyle intervention, Standard education and physician advice
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Papillary Thyroid Cancer
Oxidative Stress and Mitochondrial TERT in Papillary Thyroid Cancer.
Oxidative stress (OS) could be involved in the progression of papillary thyroid cancer (PTC). Indeed, thyroid differentiation genes are silenced by a mechanism controlled by NOX4-derived OS.
- Trial name
- TEMPEST (NCT05752669)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Auxologico Italiano
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