Clinical trials: Treatment Resistant Anxiety Disorders
Obsessive-Compulsive Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant OCD
OCD is a chronic condition with a high rate of poor responders to conventional treatments, such as antidepressants and psychotherapy.
- Trial name
- NCT01043900
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Obsessive-compulsive Disorders and Symptoms, Obsessive-Compulsive Disorder
Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a highly disabling psychiatric illness, characterized by obsessional thoughts that cause patients to perform time-consuming and distressing compulsive rituals.
- Trial name
- RCT_TOC_16 (NCT03677947)
- Testing
- Exposure and response prevention, Inference-based cognitive therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Obsessive-compulsive Disorder
Electrophysiological Recording for Patients Receiving Deep Brain Stimulation Electrode for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this project is to study live recordings from neuronal population of the human nucleus accumbens during the implantation of deep brain stimulation (DBS) electrodes for the treatment-resistant obsessive compulsive…
- Trial name
- NCT01429558
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Treatment Resistant Anxiety Disorders
Anxiety Treatment Inspired by Dialectical Behavior Therapy (DBT)
The main interest in this study is to investigate if it is possible to use strategies from Dialectical Behavior Therapy (DBT) to increase effectiveness of ordinary Cognitive Behavioral Therapy (CBT) for patients with anxiety…
- Trial name
- NCT01571089
- Testing
- DBT-inspired anxiety treatment
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Örebro County Council
Obsessive Compulsive Disorder
Ondansetron Augmentation in Treatment-resistant OCD
The aim of this study is to evaluate whether ondansetron augmentation to SSRI will improve and ondansetron discontinuation will result in worsening of obsessive compulsive symptoms among obsessive compulsive disorder resistant…
- Trial name
- NCT01303536
- Testing
- Ondansetron
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Institute of Neuroscience, Florence, Italy
Obsessive-Compulsive Disorder (OCD)
RNS for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant obsessive-compulsive disorder…
- Trial name
- NCT06782867
- Testing
- Responsive Neurostimulation (RNS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive Compulsive Disorder
Augmentation in Tx-resistant OCD: an Open Label Trial
This study examines the use of Acamprosate (Campral(R)) in the treatment of Obsessive Compulsive Disorder (OCD). The treatment of this condition is difficulty and a large percentage of patients fail to respond to medications and…
- Trial name
- NCT00590642
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Creighton University
Chronic Pain, Musculoskeletal Pain
Multicomponent Exercise and Pain Science Education for Fall Prevention in Older Adults With Chronic Musculoskeletal Pain (MovePainFall)
Chronic musculoskeletal pain is common in older adults and is associated with reduced mobility, loss of function, poorer quality of life, fear of movement, fear of falling and a higher risk of falls.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Accidental Falls, Fear of Falling
- Trial name
- MovePainFall (NCT07889024)
- Testing
- MovePainFall multicomponent exercise programme, Pain science and fall-prevention education
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Instituto Politécnico de Bragança
Treatment Resistant Major Depression
Establishing Mobile Transcranial Magnetic Stimulation
In this pilot study, investigators propose to design and create a portable TMS unit, in a van, and then test out delivering TMS in three different locations in South Carolina, all affiliated with MUSC and within 2-hours driving…
- Trial name
- TMS (NCT06748209)
- Testing
- Left prefrontal Transcranial Magnetic Stimulation (TMS), FDA cleared TMS for treating depression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Obsessive-Compulsive Disorder
Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and that tolerance (loss of therapeutic effect) to the medication…
- Trial name
- NCT00363298
- Testing
- dextro-amphetamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
The Effect of Music Therapy on Pain and Anxiety
The effect of music therapy on pain and anxiety will be evaluated in individuals with diabetes who start insulin therapy for the first time. Music will be played during the training.
- Trial name
- NCT04971655
- Testing
- Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Abant Izzet Baysal University
Obsessive-Compulsive Disorder
Transcranial Direct Current Stimulation (tDCS) for Treatment-Resistant Obsessive-Compulsive Disorder (FRONT)
Neuromodulation techniques for the treatment of Obsessive-Compulsive Disorder (OCD) have expanded with the greater understanding of the brain circuits involved in this disorder.
- Trial name
- FRONT (NCT02743715)
- Testing
- Active tDCS (transcranial direct current stimulation)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Schizophrenia, Treatment Resistant Depression (TRD)
Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment
The disruption of immune system is a key candidate in the pathogenesis of psychiatric disorders, especially those resistant to traditional treatments.
- Conditions
- Schizophrenia, Treatment Resistant Depression (TRD), Bipolar Disorder (BD), Catatonia
- Trial name
- BIO-INM (NCT07741981)
- Testing
- Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier St Anne
Obsessive Compulsive Disorder (OCD), Treatment Resistant Obsessive Compulsive Disorder
Brain-Oscillation Synchronized Stimulation of the DMPFC
This trial aims to obtain initial evidence about the clinical efficacy and modulation of neurophysiological markers in obsessive compulsive disorder (OCD) using personalized (i.e., electroencephalography (EEG)-triggered)…
- Trial name
- BOSS-OCD (NCT06942559)
- Testing
- EEG-Triggered Repetitive Transcranial Magnetic Stimulation (rTMS), Non-EEG Triggered Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder
Double Blinded, Placebo-Controlled Trial of Paliperidone Addition in SRI-Resistant Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established treatments for OCD are a specific form of Cognitive Behavioral Therapy (CBT) and the Serotonin Reuptake Inhibitor…
- Trial name
- NCT00632229
- Testing
- Paliperidone
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of South Florida
Obsessive-Compulsive Disorder
Efficacy Study of add-on Therapy With N-Acetylcysteine in Resistant Obsessive-compulsive Disorder
The primary objective of this study is to determine if N-Acetylcysteine (NAC) has efficacy as an augmentation agent in the treatment of treatment-resistant obsessive-compulsive disorder (OCD).
- Trial name
- NACTOC (NCT01555970)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Panic Disorder
Self-Guided CBT Mobile App for Treatment-Resistant Panic Disorder (CBT) Cognitive Behavioral Therapy
Treatment-resistant panic disorder (TRPD) is characterized by persistent panic symptoms despite adequate pharmacological and/or psychotherapeutic treatment.
- Trial name
- (CBT) (NCT07391943)
- Testing
- Experimental - Self-Guided CBT Mobile App
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Major Depression Moderate, Major Depression Severe
EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in older age patients diagnosed with Major Depressive Episode, Major Depression, and Bipolar Disorder…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07740694
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Obsessive-Compulsive Disorder
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
This study will evaluate the safety and effectiveness of deep brain stimulation in treating people with severe and otherwise treatment-resistant obsessive-compulsive disorder.
- Trial name
- NCT00640133
- Testing
- Active DBS
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Butler Hospital
Obsessive-Compulsive Disorder, OCD
pBFS Guided rTMS Therapy for Treatment-resistant Obsessive-Compulsive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided rTMS therapy targeting DLPFC for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964049
- Testing
- active rTMS treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory