Clinical trials: Treatment Resistant Depressive Disorder
ASD, Autism Spectrum Disorder
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
- Conditions
- ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder
- Trial name
- RETSORE-RCT (NCT06670040)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression
Intravenous Ketamine Effects on Functional Neuroanatomy
The purpose of this study is to investigate the neuroanatomical effects of ketamine treatment on patients with treatment-resistant depression.
- Trial name
- NCT04205890
- Testing
- Ketamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neurological Associates of West Los Angeles
Treatment Resistant Depression (TRD)
Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression.
Major depressive disorder (MDD) is a major contributor to impaired health worldwide. Initial antidepressant treatment of MDD does not lead to response in up to 50 % of patients.
- Trial name
- DARE (NCT07843927)
- Testing
- Dehydroepiandrosterone (DHEA)
- Where
- 9 sites in Germany
- Volunteers
- 320 people
- Sponsor
- Charite University, Berlin, Germany
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Depressive Disorder, Treatment-Resistant
A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression
The purpose of this study is to evaluate how well esketamine nasal spray works in improving depressive symptoms in participants with treatment resistant depression (TRD).
- Trial name
- NCT07053345
- Testing
- Esketamine 56 mg, Esketamine 84 mg
- Where
- 6 sites in South Korea
- Volunteers
- 47 people
- Sponsor
- Janssen Korea, Ltd., Korea
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Treatment Resistant Depression
Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation
This study evaluates an association between brain-derived neurotrophic factor(BDNF) polymorphisms and the antidepressant efficacy of transcranial magnetic stimulation device in patients with treatment-resistant depression.
- Trial name
- NCT04076124
- Testing
- Active rTMS-DLPFC, Active iTBS-DLPFC
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Major Depressive Disorder
Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms
This project is a single-arm pilot trial to investigate the feasibility, acceptability, and plausible efficacy of a 16-week resistance exercise training (RET) program for treatment of major depressive disorder.
- Trial name
- NCT05695365
- Testing
- Resistance Exercise Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Iowa State University
Depression Disorder
Maintenance Individualized Neuromodulation and Depression-detection Via Sensors for Early Treatment
This proposal seeks to carry out a prospective, single-arm open label study aimed at sustaining treatment-resistant depression (TRD) response in patients with TRD who had responded to prior individualized resting-state functional…
- Trial name
- MINDSET (NCT07779330)
- Testing
- Individualized resting-state functional connectivity-guided iTBS, Symptom-titrated algorithm-based longitudinal ECT (STABLE) algorithm
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Autism Spectrum Disorder, Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in…
- Trial name
- RESTORE (NCT05271357)
- Testing
- Bilateral TMS, Unilateral TMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression, Major Depressive Disorder
pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided DMPFC target and high-dose rTMS therapy for the treatment of patients with treatment-resistant depression
- Conditions
- Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05964036
- Testing
- active TMS
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Changping Laboratory
Suicidal Ideation, Major Depressive Disorder
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Suicide attempts are a serious concern worldwide. Currently, existing drugs take about three weeks to show effect on suicidal thoughts and drives.
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Healthy Participants
- Trial name
- NCT02037503
- Testing
- Ketamine, Saline
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Resistant Major Depressive Disorder
DBS in Treatment Resistant Major Depression
This study aims at assessing efficacy and safety of DBS for treatment of patients suffering from resistant major depression, by means of a random, controlled and crossed study.
- Trial name
- NCT01268137
- Testing
- Deep Brain Stimulation
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
MDD, Severe Depression
Sensation Seeking and TMS Response in TRD
his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD).
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- NCT07889739
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Treatment Resistant Depression
Psilocybin for Treatment-Resistant Depression
The purpose of this study is to see if psilocybin, an investigational drug, is safe and well tolerated. Researchers also want to know if psilocybin can improve symptoms of depression.
- Trial name
- NCT05029466
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Brain and Cognition Discovery Foundation
Depression, Bipolar Disorder
Insulin Resistance in Patients With Mood Disorder
Insulin resistance is known to be associated with mood disorders and cognitive difficulties. The purpose of this study is to treat depressed patients with rosiglitazone (also known as [AKA] Avandia), therefore improving glucose…
- Conditions
- Depression, Bipolar Disorder, Insulin Resistance
- Trial name
- NCT00242619
- Testing
- rosiglitazone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Treatment-resistant Depression
Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression
The primary objective of this multicenter, randomized, sham-controlled, double blind (patient and observer blinded) clinical trial is to assess the antidepressant effect of Deep Brain Stimulation (DBS) in patients with treatment…
- Trial name
- FORESEE III (NCT03653858)
- Testing
- Vercise GEVIA deep brain stimulation (DBS) system
- Where
- 2 sites in France, Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Freiburg
Treatment Resistant Depression
COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression
The CoMPACT trial is a randomized double-blinded sham-controlled study aimed at testing a novel accelerated and personalized transcranial Magnetic Stimulation (TMS) treatment for patients with Treatment Resistant Depression…
- Trial name
- CoMPACT (NCT06895863)
- Testing
- MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Device: MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil.
- Where
- 3 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Major Depressive Disorder
The Antidepressant Advisor (Study 3): fMRI Study to Predict Treatment Response in Patients With Depression
This prospective observational study (ADeSS-Study3) investigates candidate biomarkers prospectively predicting response to antidepressant medications and prognosis in major depressive disorder (MDD).
- Trial name
- ADeSS_S3 (NCT04342299)
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression
Efficacy and Safety of Antidepressant Augmentation With Lamotrigine
This study reports a clinical trial evaluating lamotrigine safety and efficacy as an antidepressant augmentation agent in treatment resistant depression, therefore adding more empirical evidence to the limited number of studies…
- Trial name
- NCT00652171
- Testing
- Lamotrigine, Amide
- Volunteers
- 34 people
- Sponsor
- Institute of Social Security of the Civil Servants of Minas Gerais