Clinical trials: Treatment Resistant Depressive Disorder
Depressive Disorder, Major
European Deep Brain Stimulation (DBS) Depression Study
To evaluate the effects of two different programming settings of deep brain stimulation (DBS) in the subgenual white matter (Brodmann Area 25 WM) as an adjunctive treatment for treatment resistant Major Depressive Disorder…
- Trial name
- NCT01331330
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 9 people
- Sponsor
- Abbott Medical Devices
Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD)
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)
Psilocybin, a serotonin receptor agonist in the brain, significantly and quickly improves depressive symptoms while inducing profound acute subjective effects.
- Trial name
- PSILOTRAZ (NCT07210112)
- Testing
- Psilocybin 25 mg per os, Trazodone 5mg, Trazodone 30 mg
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier St Anne
Depressive Disorder
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Phase III, open label, randomised, multicentre, blind for evaluators clinical trial to evaluate the efficacy of esketamine nasal spray at flexible dosis compared to aripiprazole in elderly participants (>60 years) who suffer from…
- Trial name
- CESAR (NCT07153406)
- Testing
- Experimental regimen, Control regimen
- Where
- 9 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Depressive Disorder, Major
Ketamine for Treatment Resistant MDD
This study aims to openly test the long-term safety, tolerability and effectiveness of repeated administration of IM/SC ketamine for treatment resistant MDD.
- Trial name
- NCT04021433
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Major Depressive Disorder
Home-based Non-invasive Brain Stimulation for Treatment-resistant Depression Feasibility, Efficacy and Biomarker of Treatment Response
Depression has a yearly prevalence superior to 5%, but a 30% of patients cannot benefit of pharmacological treatment, resulting resistant to it.
- Trial name
- NCT05930509
- Testing
- Non-invasive transcranial direct current stimulation (tDCS)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Institut Guttmann
Major Depressive Disorder, Treatment Resistant Depression
pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression
To explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder.
- Conditions
- Major Depressive Disorder, Treatment Resistant Depression, MDD
- Trial name
- NCT05976009
- Testing
- active rTMS stimulating
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Changping Laboratory
Treatment-resistant Depression (TRD)
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD.
- Trial name
- NCT07553637
- Testing
- ALTO-207
- Where
- 63 sites in United States, United Kingdom
- Volunteers
- 178 people
- Sponsor
- Alto Neuroscience
Major Depressive Disorder, MDD
A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD)
The study will only detect hypomanic symptoms in treatment resistant MDD patients by mean of HCL-32 administration. Further re-evaluation of MDD diagnosis is not a direct aim of the study.
- Trial name
- Improve (NCT01344733)
- Where
- 29 sites in Italy
- Volunteers
- 660 people
- Sponsor
- AstraZeneca
Major Depressive Disorder, Treatment Resistant Depression
Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation
Major depressive disorder (MDD) is a complex and severe mental illness, characterized by multiple symptoms, and is a leading cause of non-fatal health loss.
- Trial name
- NCT06542094
- Testing
- Deep Brain stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- West China Hospital
Depressive Disorder, Mood Disorders
Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial
In this double blind randomised controlled pilot trial the investigators aim to determine the efficacy of minocycline as an adjunct to treatment as usual in patients with major depressive disorder.
- Conditions
- Depressive Disorder, Mood Disorders, Depressive Disorder, Treatment Resistant, Antidepressive Agents
- Trial name
- NCT02263872
- Testing
- Minocycline
- Where
- 3 sites in Pakistan
- Volunteers
- 41 people
- Sponsor
- Pakistan Institute of Living and Learning
Treatment Resistant Depression (TRD)
Neuronavigated aiTBS for TRD
The purpose of this study is to confirm the efficacy of two recently introduced repetitive transcranial magnetic stimulation (rTMS) interventions - accelerated intermittent theta-burst stimulation (aiTBS) and individualized…
- Trial name
- NCT07329153
- Testing
- aiTBS
- Where
- 3 sites in United States
- Volunteers
- 247 people
- Sponsor
- University of Texas Southwestern Medical Center
Treatment Resistant Depression
Psilocybin in Depression Resistant to Standard Treatments
A single centre clinical trial to evaluate the feasibility, safety and efficacy of psilocybin, given under supportive conditions, in a randomised, blinded design in adult participants with treatment resistant major depressive…
- Trial name
- PsiDeR (NCT04959253)
- Testing
- Psilocybin assisted therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Depression
Examining the Efficacy of Orbitofrontal Cortex rTMS for Depression
This trial will compare the efficacy of active inhibitory OFC-rTMS to sham OFC-rTMS in major depression. The trial will include structural and functional MRI, EEG, and behavioral measures obtained before, during, and after…
- Trial name
- OFC-rTMS (NCT02797210)
- Testing
- Continuous theta-burst stimulation
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Clinical, Cognitive and Neural Effects of Potentiation of ECT by rTMS in Treatment-Resistant Depression
Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression (TRD). However, due to response delay and cognitive impairment, ECT remains an imperfect treatment.
- Trial name
- STIMAGNECT2 (NCT06391723)
- Testing
- Active rTMS
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier du Rouvray
Treatment Resistant Depression
Efficacy of Deep Brain Stimulation(DBS) for Treatment-Resistant Depression(TRD)
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation in patients with Treatment-resistant Depression (TRD) targeting the ventral capsule/ventral striatum (VC/VS), Brodmann…
- Trial name
- DBS for TRD (NCT06542900)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Treatment Resistant Depression, Depression
Glutamate Emotion Memory Study
Clinical depression often includes a pessimistic view of things which have happened in the past and an impairment in the ability to experience pleasure or looking forward to things.
- Conditions
- Treatment Resistant Depression, Depression, Major Depressive Disorder
- Trial name
- GEMS (NCT05809609)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Depression
Post Marketing Study to Evaluate the Resource Utilization of Patients Suffering From Resistant Depression Treated With Deep TMS in Comparison to Treatment as Usual
The aim of the study is to evaluate the efficacy of the Deep TMS compare to TAU and the different in resource utilization of treating depression with Deep TMS compare to the TAU.
- Trial name
- NCT02260765
- Testing
- dTMS
- Where
- United States
- Sponsor
- Brainsway
Treatment Resistant Depression
Accelerated TBS in Late Life Depression
This study is a single-arm, open-label, feasibility trial for the assessment of the clinical effects of a course of accelerated bilateral sequential theta burst stimulation (TBS) for late life depression (LLD).
- Trial name
- NCT05119699
- Testing
- MagPro X100/R30 stimulator equipped with the B70 fluid-cooled coil
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Treatment Resistant Major Depression Disorder
DBS of the Habenula for Treatment- Resistant Major Depression
The habenula(Hb) is an epithalamic structure located at the center of the dorsal diencephalic conduction system, a pathway involved in linking forebrain to midbrain regions.
- Trial name
- NCT03347487
- Testing
- Deep brain stimuation system implantation
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Ruijin Hospital
Treatment Resistant Depression
Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms
This study will be an open-label 6-week (30 session) trial of active repetitive transcranial magnetic stimulation (rTMS) using a fixed frequency (10 Hz) but varying stimulation intensities using a 3+3 study design for safety and…
- Trial name
- NCT02611206
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS): intensity 80% MT, Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 100% of MT, Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 120% of MT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota