Clinical trials: Treatment Resistant Disorders
Group Meetings
Feasibility of Therapy Integrating Peer-sharing, Technology, Aerobic and Resistance Training (TIPSTART)
The purpose of this randomized controlled clinical trial with first-generation college students with symptoms of mental illness is to test the preliminary feasibility and efficacy of TIPSTART, a multi-faceted, mental health and…
- Trial name
- TIPSTART (NCT04813198)
- Testing
- TIPSTART
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Malaria
Kilimanjaro IPTi Drug Options Trial
Malaria and anaemia are major causes of morbidity and mortality in children in sub-Saharan Africa. Administration of three courses of sulfadoxine/pyrimethamine (SP) as intermittent preventive treatment (IPTi) to infants when they…
- Trial name
- NCT00158574
- Testing
- sulphadoxine-pyrimethamine, mefloquine, Chlorproguanil-dapsone
- Where
- Tanzania
- Volunteers
- 2,419 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Insulin Resistance, Hyperglycemia
Biomarkers of Prednisolone Treatment (P05888)
Primary objective: To identify a biomarker or biomarker-set for the adverse metabolic effects of various doses of prednisolone treatment. Secondary objectives: To describe the PK of prednisolone and PD of a series of biomarkers.
- Conditions
- Insulin Resistance, Hyperglycemia, Glucose Intolerance
- Trial name
- NCT00971724
- Testing
- Prednisolone
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Periodontitis, Prediabetes
Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects
This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.
- Trial name
- PARODIA2 (NCT02830113)
- Testing
- non-surgical periodontal treatment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yaounde Central Hospital
Mental Disorders
Brain MRI (Magnetic Resonance Imaging) Scans of Patients With Treatment Resistant Depression (TRD) and Healthy Controls
Treatment resistant depression (TRD) is a major health concern, with 10% of patients with major depressive disorder not responding to conventional treatments.
- Trial name
- NCT01162434
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Bristol
HIV/AIDS
Characteristics and Outcomes of Patients Who Received Etravirine and/or Darunavir
The objectives of this data collection activity are to: 1. Describe the baseline demographics, clinical and laboratory profile of patients who ever received darunavir (DRV) and/or etravirine (ETR), at the time of initiation on…
- Trial name
- NewHorizon (NCT04194021)
- Where
- 5 sites in Cameroon, Eswatini and 3 more
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Advanced Pancreatic Adenocarcinoma, Pancreatic Adenocarcinoma
Resistance Training Intervention to Improve Physical Function in Patients With Pancreatic Cancer Receiving Combination Chemotherapy or Have Undergone Surgery, PancStrength Study
This clinical trial studies the safety of a real-time tele-exercise resistance training (training done using a tablet) in maintaining skeletal muscle, strength, physical function, and health-related quality of life in patients…
- Conditions
- Advanced Pancreatic Adenocarcinoma, Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT04837118
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Ascariasis
Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda
The goal of this prospective follow-up study nested within an open-label randomized controlled trial is to investigate the unexpectedly high prevalence of Ascaris lumbricoides infection observed 3-4 months after school-based mass…
- Trial name
- FACEIT-FU (NCT07873398)
- Testing
- Albendazole 400mg, Ivermectin 3 mg
- Where
- Uganda
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Depression, Major Depressive Disorder
Reward Emotion Learning and Ketamine Study
Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described.
- Conditions
- Depression, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- RELAKS (NCT04850911)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sleep Disorder
Better Days, Better Nights: Treatment for Sleep Difficulties (Telephone Coached)
The purpose of the Strongest Families (formerly Family Help Program)is to evaluate the effectiveness of the Strongest Families distance intervention compared to usual or standard care that is typically provided to children with…
- Trial name
- Sleep (NCT00338429)
- Testing
- FHP Sleep Program
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Pre Diabetes, Metabolic Syndrome
Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?
Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes.
- Trial name
- NCT06668714
- Testing
- Lactate + mixed meal, PET-scan, Mixed meal with 18F-FTHA
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Smoking Cessation, Diabetes Mellitus, Type 2
Incentivized Smoking Cessation for Diabetics
This pilot study aims to test the feasibility of providing incentives to patients with T2D contingent on remote biochemical verification using a smartphone carbon monoxide (CO) monitor.
- Trial name
- NCT03527667
- Testing
- Financial incentives
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Major Depressive Disorder, Treatment Resistant Depression
Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression
According to the World Health Organization, MDD is attributed as the leading cause of disability worldwide, leaving 300 million individuals affected.
- Trial name
- NCT03977038
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Prolactinoma, Insulin Resistance
Insulin Resistance in Women With Prolactinoma
Prolactin is suggested to influence insulin resistance, but scarce data is available on the metabolic profile of patients with prolactinoma.
- Conditions
- Prolactinoma, Insulin Resistance, Hyperlipidemia
- Trial name
- NCT00481299
- Where
- Brazil
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Depression, Mood Disorders
Rapid Antidepressant Effects of Ketamine in Major Depression
Depressive disorders may be severe, chronic and often life-threatening illnesses. Impairment in physical and social functioning resulting from depression can be just as severe as other chronic medical illnesses.
- Conditions
- Depression, Mood Disorders, Major Depresssion
- Trial name
- NCT00088699
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obesity and Overweight, Obesity, Morbid
Impact of Nutritional Intervention With Probiotics and Prebiotics on Obesity.
Obesity is one of the most severe and prevalent non-communicable diseases worldwide, affecting an estimated one-third of the population in Spain.
- Conditions
- Obesity and Overweight, Obesity, Morbid, Metabolic Syndrome
- Trial name
- MicoBeBioticos (NCT06722443)
- Testing
- Probiotic, Prebiotic, Synbiotic
- Where
- Spain
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Obstructive Sleep Apnea, Pregnancy Related
Obstructive Sleep Apnea Treatment and Insulin Sensitivity in Pregnancy
This study will evaluate the effect of treatment of obstructive sleep apnea on insulin sensitivity in pregnant women. Women in their third trimester of pregnancy will be randomized to receive treatment or no treatment for one…
- Conditions
- Obstructive Sleep Apnea, Pregnancy Related, Insulin Sensitivity
- Trial name
- NCT04013399
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Barnes-Jewish Hospital