Clinical trials: Treatment Resistant Major Depression
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Major Depressive Disorder
Intranasal Ketamine in Treatment-Resistant Depression
The objective of the current study is to investigate the safety and efficacy of a single dose of intranasal (IN) ketamine in treatment-resistant depression (TRD).
- Trial name
- NCT01304147
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James Murrough
Major Depressive Disorder, Treatment Resistant Depression
MAO-B Occupancy in Depressed Patients
The study is looking at assessing monoamine oxidase B (MAO-B) occupancy in depressed patients before and after medication treatment using positron emission tomography (PET) scan.
- Trial name
- MOCP (NCT04841798)
- Testing
- [11C]SL25.1188 PET radiotracer
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, MDD
A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD)
The study will only detect hypomanic symptoms in treatment resistant MDD patients by mean of HCL-32 administration. Further re-evaluation of MDD diagnosis is not a direct aim of the study.
- Trial name
- Improve (NCT01344733)
- Where
- 29 sites in Italy
- Volunteers
- 660 people
- Sponsor
- AstraZeneca
Depressive Disorder, Major
Ketamine for Treatment Resistant MDD
This study aims to openly test the long-term safety, tolerability and effectiveness of repeated administration of IM/SC ketamine for treatment resistant MDD.
- Trial name
- NCT04021433
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Major Depressive Disorder
Adjunct Minocyline in Treatment-resistant Depression
This study examines the antidepressant efficacy of minocycline as an adjunct to an antidepressant standard treatment (AD-ST), for patients with unipolar major depressive disorder (MDD).
- Trial name
- Mino-TRD (NCT02456948)
- Testing
- Minocycline
- Where
- 9 sites in Germany
- Volunteers
- 168 people
- Sponsor
- Charite University, Berlin, Germany
Major Depressive Disorder, Treatment Resistant Depression
DBS for TRD With the Medtronic Percept PC
Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant.
- Trial name
- NCT05773755
- Testing
- Medtronic Percept PC DBS system
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helen Mayberg, MD
Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder
Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression
The goal of this clinical trial is to evaluate whether precision closed-loop neuromodulation treatments can improve depressive symptoms and daily functioning in people with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT07783906
- Testing
- Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
The objective of this study is to evaluate the safety, tolerability, and preliminary efficacy of the Motif eXternally powered Cortical Stimulation (XCS) System when used as indicated for treatment-resistant depression (TRD).
- Trial name
- RESONATE (NCT07594483)
- Testing
- Motif XCS System
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Motif Neurotech, Inc.
Depression, Depressive Disorder
Assessment of the Safety and Effectiveness of Cortical Stimulation in Subjects With Major Depressive Disorder
The purpose of this study is to assess the safety and effectiveness of cortical stimulation to the cerebral cortex of subjects who have suffered from treatment-resistant depression and have failed routine attempts at controlling…
- Trial name
- PROSPECT (NCT00380042)
- Testing
- Cortical Stimulation
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Northstar Neuroscience
Major Depressive Disorder, Treatment Resistant Depression
DBS for TRD With the Medtronic Summit RC+S
Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant.
- Trial name
- NCT04106466
- Testing
- Medtronic Summit RC+S DBS system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen Mayberg, MD
Major Depressive Disorder
Vagal Nerve Stimulation for Treatment Resistant Major Depression
The purpose of this study is to 1) explore whether vagal nerve stimulation (nVNS) using a hand- held non-invasive device (gammaCore™) works to treat depression and 2) to confirm gammaCore™'s safety profile.
- Trial name
- NCT04990687
- Testing
- gammaCore™
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
MDD, Severe Depression
Sensation Seeking and TMS Response in TRD
his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD).
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- NCT07889739
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Major Depressive Disorder, Bipolar Disorder
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
- Trial name
- NCT05172271
- Testing
- MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Episode, Depression - Major Depressive Disorder
Personalized Ultrasonic Brain Stimulation for Depression (R61)
This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will be delivered using a range of stimulation…
- Conditions
- Major Depressive Episode, Depression - Major Depressive Disorder, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT06902298
- Testing
- LTFUS to SCC, LTFUS to ALIC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brian Mickey
Treatment Resistant Depression
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
This study is looking at the efficacy, durability, safety, and tolerability of multiple single doses of Ketamine vs. active placebo for treating patients with treatment resistant depression who are taking an antidepressant that…
- Trial name
- NCT01920555
- Testing
- Ketamine
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Clinical Trial on Efficacy of rTMS to Improve ECT in Treatment-Resistant Depression
It's a prospective, multicentric, randomized, controlled study concerning 56 patients with treatment-resistant depression (TRD).
- Trial name
- STIMAGNECT (NCT02830399)
- Testing
- active rTMS-ECT
- Where
- 3 sites in France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier du Rouvray
Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Depressive Disorder
Major Depressive Disorder (MDD) is one of the most prevalent mental illnesses in North America, in which 30% - 40% fail to respond to conventional treatment.
- Trial name
- NCT01515215
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Centre for Addiction and Mental Health
Treatment-Resistant Major Depressive Disorder
Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS)
Clinical trial aimed at evaluating whether a single infusion of tocilizumab, a medication that blocks the action of an inflammatory molecule called interleukin-6 (IL-6), can reduce symptoms of treatment-resistant major depression…
- Trial name
- NCT07052058
- Testing
- Tocilizumab, Normal Saline (0.9% NaCl)
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression - Major Depressive Disorder
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
About one in three people with major depression respond poorly to standard antidepressant treatments. This kind of depression is called treatment-resistant depression, and it can lead to long-term disability, financial…
- Trial name
- NCT07164755
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- King's College London