Clinical trials: Treatment for Opioid Use Disorder
Stimulant Use Disorder
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
This project will evaluate the ability of Mirtazapine (MZP), a pharmacologically unique medication with a growing body of evidence to support its efficacy and safety for the treatment of methamphetamine (MA) use among medication…
- Trial name
- MIRROM (NCT06323837)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington State University
Opioid Use Disorder, HIV
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans
Opioid use disorder (OUD) confers a higher risk of acquiring and transmitting infectious diseases, which may have long-term health consequences in Veterans.
- Conditions
- Opioid Use Disorder, HIV, Hepatitis C Virus, Gonorrhea
- Trial name
- NCT06766331
- Testing
- Integrated care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder, Sleep Disturbance
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use…
- Trial name
- MOUD (NCT06104280)
- Testing
- Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Therapeutic Opioid Induced Constipation (Disorder)
Use of MgSO4 for Pain After Bariatric Surgery
The purpose of this study was to investigate the effect of magnesium sulfate on pain management for pain after sleeve gastrectomy operation
- Trial name
- NCT03355807
- Testing
- Magnesium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yeditepe University Hospital
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Opioid Use Disorder, Peer Recovery Supporters
Peer Recovery Support for Opioid Use Disorder Treatment Retention
The goal of this clinical trial is to learn whether adding peer recovery support services to standard opioid use disorder (OUD) treatment in primary care helps patients stay in treatment longer.
- Conditions
- Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care
- Trial name
- NCT07620171
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-use Disorder
Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.
The purpose of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or…
- Trial name
- ISTOP (NCT03212794)
- Testing
- Recovery coach
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Chronic Pain
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription…
- Conditions
- Pain, Chronic Pain, Opioid Dependence, Opioid Use
- Trial name
- NCT03576781
- Testing
- Real iTBS, Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Problems Related to Social Environment
Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder
Using a stepped-wedge randomized controlled trial, the study will test whether a clinic-level multidimensional intervention conducted in 36 opioid treatment programs (OTPs) will improve clinical decision making, regulatory…
- Trial name
- NCT05675735
- Testing
- Clinic-Level Multidimensional Intervention
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cocaine Dependence, Cocaine-Related Disorders
Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients
Background: The effectiveness of methadone maintenance for treatment of heroin addiction has been well established. However, patients maintained on methadone may relapse to cocaine use, even when they are enrolled in a…
- Conditions
- Cocaine Dependence, Cocaine-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT00780702
- Testing
- Airipiprazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Criminal Justice
Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews
This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a…
- Conditions
- Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
- Trial name
- NCT06354465
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lifespan
Chronic Pain, Pain, Musculoskeletal
Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment
This study will use multiple methods to assess the feasibility of conducting a fully powered multisite clinical trial to test the effectiveness of integrating mindfulness-based interventions into physical therapy for patients…
- Conditions
- Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
- Trial name
- PT-IN-MIND (NCT05875207)
- Testing
- Mindfulness based practice, Control/Standard Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Utah
Opioid-Related Disorders, Opioid Dependence
An Innovative Intervention for OUD Treatment
The Bridge Device (BD) is a neuromodulator medical device that has been cleared by the FDA for Opioid Use Disorder (OUD) treatment.
- Conditions
- Opioid-Related Disorders, Opioid Dependence, Opioid Addiction, Opioid Withdrawal
- Trial name
- Bridge (NCT04325659)
- Testing
- Bridge Device, Lofexidine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid-Related Disorders, Alcohol-Related Disorders
Imaging Biomarker for Addiction Treatment Outcome
Background: Many people suffer from drug addiction. But currently, treatments are not very effective. One group of patients in this study are enrolled in addiction treatment through physician health programs (PHPs).
- Trial name
- NCT03427424
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder, Treatment Adherence
Digital Health Intervention to Support Opioid Use Disorder Treatment
In prior studies, the investigative team developed a combined computer- and text message-delivered personalized-feedback intervention (iENDURE) designed to enhance motivation and improve tolerance of distress to support the early…
- Trial name
- iENDURE (NCT03842384)
- Testing
- iENDURE
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Psychoeducation
Cognitive Behavior Therapy for Depression, Stigmatization, Criminogenic Cognition, and Quality of Life Among Patients With Opioid Use Disorder (OUD): A Randomized Control Trial.
to investigate the impact of cognitive behavior therapy for psychiatric problems among patients with opioid use disorder with relapse condition.
- Trial name
- CBT with OUD (NCT06326515)
- Testing
- psychoeducation, Stigma Reduction and Relapse Management
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Opioid-Related Disorders
Youth Opioid Recovery Support: Improving Care Systems
Opioid addiction, also referred to as opioid use disorder, among young people is a growing health concern for patients and their families.
- Trial name
- YORS (NCT04015115)
- Testing
- Youth Opioid Recovery Support service model
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cannabis-Related Disorder, Cannabis Abuse
Implementing Screening for Cannabis and Other Drug Use Disorders in Primary Care: Impact on Diagnosis and Treatment
Our proposed evaluation study is designed to evaluate the impact of a recently completed stepped wedge cluster randomized trial, conducted at Kaiser Permanente Washington (KPWA), of an intervention to improve care and management…
- Conditions
- Cannabis-Related Disorder, Cannabis Abuse, Drug Abuse, Drug Use Disorders
- Trial name
- NCT06249542
- Testing
- Care Delivery Improvement Intervention
- Volunteers
- 363,936 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Community Reinforcement And Family Training, Family Health
We The Village Family Support Study
The United States is in the midst of an opioid crisis. Over-prescription of opioid analgesic pain relievers contributed to a rapid escalation of use and misuse of these substances across the country.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT04250077
- Testing
- Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Opioid-use Disorder, Overdose of Opiate
Patient Reported Outcomes for Opioid Use Disorder
The goal of the project is to build a clinical data research infrastructure that will begin to enhance capacity to use electronic health record (EHR) data and patient reported outcomes measures (PROs) to conduct opioid related…
- Conditions
- Opioid-use Disorder, Overdose of Opiate, Patient Participation
- Trial name
- NCT03985163
- Testing
- Patient Reported Outcomes Electronic Survey
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Yale University