Clinical trials: Treatment of Periodontitis
Periodontitis
Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis
This study is to determine whether scaling and root planing (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with SRP…
- Trial name
- NCT00297531
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 4 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Ondine Research Laboratories
Gingivitis
Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)
The purpose of this study is to evaluate the safety of oral topical application of Amnion-derived Cellular Cytokine Solution (ACCS) in subjects with gingivitis
- Trial name
- NCT02071199
- Testing
- 1X ACCS (Amnion-derived Cellular Cytokine Solution), Normal saline, 0.3X ACCS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Periodontitis
Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis
This study is to determine whether scaling and root planning (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with…
- Trial name
- NCT00297518
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ondine Research Laboratories
Periodontal Diseases, Periodontitis
Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis
This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long…
- Conditions
- Periodontal Diseases, Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05425784
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 3 sites in Finland
- Volunteers
- 41 people
- Sponsor
- Koite Health Oy
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Chronic Periodontitis
A Clinical Trial of YH14642 in Patients With Chronic Periodontal Disease
This study is designed to evaluate the efficacy and the safety of YH14642 in Korea patients with chronic periodontitis, in order to investigate the recommended therapeutic dose.
- Trial name
- YH14642 (NCT01499225)
- Testing
- YH14642 500mg Tab, INSADOL[Zea mays L. extract] 35mg Tab, DENTISTA[Doxycycline hyclate] 20mg Cap
- Where
- South Korea
- Volunteers
- 162 people
- Sponsor
- Yuhan Corporation
Periodontitis
PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave
This is a pivotal, prospective, randomized, blinded, multicenter study to evaluate two treatments of photodynamic disinfection in adults with chronic periodontal disease.
- Trial name
- NCT00336661
- Testing
- PerioWave
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Ondine Research Laboratories
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Chronic Periodontitis
IgY Efficacy on Periodontitis Patients
Patients visiting National Hospital of Odonto-Stomatology for treating periodontitis used a food supplement (lozenge) containing chicken egg antibody (IgY) against Porphyromonas gingivalis gingipains as an adjunct to conventional…
- Trial name
- NCT02705885
- Testing
- lozenges containing IgY
- Volunteers
- 60 people
- Sponsor
- Immunology Research Institute in Gifu
Periodontal Disease
Periodontal Disease Treatment of a Physically Challenged Population
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush.
- Trial name
- PDT (NCT01718912)
- Testing
- metronidazole-nystatin oral rinse
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oravital Inc
Apical Periodontitis
A Study to Compare Various Root Canal Cleaning Devices Based on Cavitation,Ultrasonic and Conventional Methods.
The goal of this clinical trial is to compare the effectiveness of various root canal cleaning devices based on the principle of cavitation, ultrasonics, and conventional methods in a normal healthy adult population aged between…
- Trial name
- NCT06005545
- Testing
- Passive Ultrasonic Irrigation (PUI) group, Endoclean (EC) group, Conventional group
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
Periodontal Disease
Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis
The purpose of this study is to determine whether ST266 will reduce pocket depth (PD) as an adjunctive to scaling and root planing (SRP) in subjects with moderate to severe periodontal disease.
- Trial name
- NCT02761993
- Testing
- ST266, Saline (0.9% NaCl)
- Where
- 6 sites in United States
- Volunteers
- 151 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Moderate to Severe Chronic Periodontitis
Evaluation of the KLOX BioPhotonic OraLum Gel With a LED Curing Lamp in Moderate to Severe Chronic Periodontitis
Multicenter, prospective, interventional open case series study using a randomized split-mouth design in moderate to severe chronic periodontitis patients having half-mouth treated with the KLOX BioPhotonic OraLum gel with a LED…
- Trial name
- NCT02325570
- Testing
- KLOX BioPhotonic OraLum Gel, Scaling and Root Planing (SRP)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- KLOX Technologies Inc.
Periodontitis, Plaque, Dental
Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health
This early-stage study is designed to determine the efficacy of the CE-approved, antibacterial, dual-light Lumoral method in periodontitis patients.
- Conditions
- Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05361590
- Testing
- Lumoral device
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Periodontitis, Coronary Disease
Periodontal Therapy in a Primary Prevention of Cardiovascular Disease
Cardiovascular diseases (CVD) are still considered the main cause of mortality and morbidity all over the world. In the last years, efforts have been made to define more effective therapeutic and preventive strategies.Periodontal…
- Trial name
- NCT02081976
- Testing
- Integrated Care Group, Standard Care Group
- Where
- India
- Volunteers
- 57 people
- Sponsor
- Macmillan Research Group UK
Parodontitis
Evaluation of the Efficacy of STERIFY GEL in the Treatment of Periodontitis Following Scaling and Root Planing
The purpose of this clinical study is to evaluate the safety and efficacy of treating periodontal disease with the STERIFY GEL medical device in combination with SRP procedure, in terms of periodontal pocket healing.
- Trial name
- SFYCT (NCT05975177)
- Testing
- Sterify Gel, Scaling and root planing
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Sterify S.r.l.
Periodontal Pocket, Periodontitis
Multicenter Study on the Use of a Collagen-based Hydrogel for the Treatment of 153 Periodontal Pockets in 38 Adults With Generalized Stage III Periodontitis
This is a prospective, observational, multicenter study designed to evaluate the real-world efficacy and safety of H42®, a collagen hydrogel, in the treatment of periodontal pockets.
- Trial name
- NCT07592377
- Testing
- H42® Collagen Hydrogel for the non-surgical treatment of periodontal pockets
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Bioteck S.p.A.
Periodontitis
Acceptance and Preference of Lidocaine Gel Compared to Injection Anesthesia After Non Surgical Periodontal Treatment
This project is a national, open label, multicenter, randomized split-mouth study in patients from 18 to 70 years of age to compare the efficacy and acceptability of lidocaine gel compared to injection anesthesia with articaine…
- Trial name
- NCT03354312
- Testing
- Lidocaine Hydrochloride 1% Gel, Articaine hydrochloride/epinephrine (adrenaline) hydrochloride
- Where
- 5 sites in Germany
- Volunteers
- 94 people
- Sponsor
- Chemische Fabrik Kreussler & CO GmbH
Probiotics, Periodontitis
Efficacy of Supplementation With Probiotics as Adjuvant to Mechanical Treatment in Chronic Periodontitis
It aims to demonstrate the superiority of a 6-week supplementation with Lactibiane Buccodental compared to placebo, as adjunctive therapy in chronic periodontitis in patients with generalized chronic periodontitis
- Trial name
- NCT03554187
- Testing
- Ultrasonic periodontal Debridement, with appropriate device, Analyzes of periodontopathogenic bacteria, IL1B test
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- PiLeJe
Periodontitis
Regular Home Use of Dual-light Photodynamic Therapy in the Management of Chronic Periodontitis
The study is a single site, randomized clinical trial designed to determine the efficacy of the Lumoral treatment in periodontitis patients.
- Trial name
- HOPE-CP (NCT05278416)
- Testing
- Lumoral treatment -device and Lumorinse tablets
- Where
- Finland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy