Clinical trials: Treatment of Periodontitis
Periodontal Diseases, Periodontal Inflammation
Electroacupuncture as an Adjunct to Non-Surgical Periodontal Therapy
The aim of this randomized, single-masked, controlled clinical trial study was to determine if the administration of electro acupuncture improves the outcomes obtained in combination with non-surgical periodontal therapy.
- Conditions
- Periodontal Diseases, Periodontal Inflammation, Periodontitis, Acupuncture
- Trial name
- NCT06247007
- Testing
- Electroacupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Didem OZKAL EMINOGLU
Treatment of Periodontitis, Guided Biofilm Therapy
Comparison of Current Subgingival Debridement Methods
Our study aimed to compare the effectiveness of current subgingival debridement methods used in the treatment of Stage 1 and Stage 2 periodontitis patients, the aesthetic condition achieved after these treatments, and the pain…
- Conditions
- Treatment of Periodontitis, Guided Biofilm Therapy, Subgingival Plaque, Subgingival Debridement
- Trial name
- NCT06835452
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Periodontitis
Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects
Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop…
- Trial name
- NCT07522684
- Testing
- Polynucleotide and hyaluronic acid-based gel, Control, Xenogeneic bone graft
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Non Surgical Periodontal Therapy
Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients
1. To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months)…
- Trial name
- NCT06270004
- Testing
- nonsurgical periodontal therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontitis
Advanced Platelet-Rich Fibrin Plus in Nonsurgical Periodontal Therapy
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to…
- Trial name
- NCT07782736
- Testing
- Scaling and Root Planing, Advanced Platelet-Rich Fibrin Plus
- Where
- Vietnam
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Oxidative Stress, Chronic Apical Periodontitis
Effect of Different Root Canal Sealers on Oxidative Stress Markers
The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session.
- Trial name
- NCT07059481
- Testing
- Root Canal Treatment and Sample Collection, PAI Score Comparasion
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- bengi gülgü
Peri-Implantitis, Type 2 Diabetes Mellitus
Surgical Treatment of Periimplantitis in Patients With Risk Factors
This study evaluates clinical and radiographic parameters among riks factor groups in patients with periimplantitis. This study will also treat and evaluate the patients response before and after surgical treatment.
- Conditions
- Peri-Implantitis, Type 2 Diabetes Mellitus, Smoking, Cigarette, Periodontal Diseases
- Trial name
- NCT03814434
- Testing
- Non-Surgical treatment, Surgical Treatment
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Luiz Antonio Pugliesi Alves de Lima
Chronic Periodontitis
Laser Assisted Nonsurgical Periodontal Treatment
Periodontitis is a chronic inflammatory disease caused by mixed infections with the subgingival microbiota being organized as a biofilm that, if untreated, may result in breakdown of the periodontal tissues in susceptible…
- Trial name
- NCT03387371
- Testing
- Ultrasonics, Gracey Curettes, Er:YAG Laser
- Volunteers
- 38 people
- Sponsor
- Bezmialem Vakif University
Periodontitis
Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis
The aim of the study was to assess the effect of nitazoxanide delivered subgingivally as thermosensitive hydrogel on the clinical and biochemical outcomes of SRP in patients with moderate periodontitis.
- Trial name
- NCT04768530
- Testing
- Scaling and Root Planing, Nitazoxanide hydrogel
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Maha Talaab
Periodontitis
Adjunctive Laser for Periodontal Intrabony Defects
Participants with periodontitis and presence of bilateral intrabony defect will be randomised to have one side of the mouth undergo root surface debridement using hand instruments and ultrasonic scaler alone, while the…
- Trial name
- NCT04847830
- Testing
- Er:YAG laser (Waterlase), root surface dbridement
- Volunteers
- 28 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Periodontitis, Bone Resorption
Sodium Alendronate in Non Surgical Periodontal Therapy
In the past few years, studies have evaluated the effect of systemic use of sodium alendronate, especially in the treatment of structural bone defects caused by periodontal diseases.
- Trial name
- SANSPET (NCT02470611)
- Testing
- Sodium alendronate
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Federal University of Minas Gerais
Chronic Periodontitis
Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol…
- Trial name
- NCT02800902
- Testing
- Rosuvastatin, Atorvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis, Laser
Clinical Evaluation of the Effect of LANAP as an Adjunct Treatment in Management of Patients With Chronic Periodontitis
this study evaluate the effect of LANAP (Laser Assisted New Attachment Procedure) as an Adjunct Treatment in Management of Patients With Chronic Periodontitis and assay the effect of LANAP on periodontal indexes like BOP, CAL…
- Trial name
- NCT03365167
- Testing
- LANAP (Laser Assisted New Attachment Procedure), LANAP off
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Diabetes Mellitus, Type 1, Periodontal Diseases
Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients
The aim of this study is to evaluate adjuvant effect of antimicrobial photodynamic therapy in periodontal treatment and salivary status of type 1 diabetes patients.
- Conditions
- Diabetes Mellitus, Type 1, Periodontal Diseases, Periodontal Pocket
- Trial name
- NCT03102892
- Testing
- Scaling root planing, Antimicrobial photodynamic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Chronic Periodontitis
Perio. Maint. With Diode LBR
The primary aim of this pilot study is to determine whether the test methods described feasibly achieve the goal defined for a future clinical study.
- Trial name
- NCT05276817
- Testing
- Epic Diode, HP
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Biolase Inc
Periodontal Diseases
Efficacy of Subgingival Erythritol Air Polishing in Treatment of Periodontal Pockets
Periodontitis is an inflammation associated with destruction of the periodontium that ultimately, if not treated, leads to tooth loss.
- Trial name
- NCT05798871
- Testing
- Subgingival erythritol air polishing, Conventional root planing
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Aggressive Periodontitis
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals.
- Trial name
- NCT05297084
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periapical Periodontitis, Root Canal Infection
Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using different methods of irrigation activation.
- Trial name
- NCT03990584
- Testing
- three irrigation activation methods, conventional needle irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
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