Clinical trials: Treatment of Periodontitis
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Periodontitis, Treatment Outcome
2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale
Objectives: Evaluation of endodontic treatment success is largely based on radiographical assessment of anatomical and treatment-related parameters of teeth with apical periodontitis (AP).
- Trial name
- NCT04495270
- Testing
- Analysis of treatment outcomes of teeth with apical periodontitis based on cone-beam computed tomography and estimated by means of Periapical and Endodontic Status Scale"
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Periodontitis, Coronariopathy
Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies
Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization.
- Trial name
- NCT02150005
- Testing
- Periodontal treatment
- Volunteers
- 22 people
- Sponsor
- Universidade Veiga de Almeida
Periodontal Diseases, Periodontitis
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy
This prospective cross-sectional study evaluates the frequency and risk factors of periodontal disease in head and neck cancer patients who have undergone radiotherapy.
- Trial name
- NCT06667362
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Ain Shams University
Peri-implantitis, Periodontitis
Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis
This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients…
- Conditions
- Peri-implantitis, Periodontitis, Non-surgical Periodontal Therapy
- Trial name
- MINST vs NSPT (NCT07466966)
- Testing
- Non-Surgical Peri-implant Therapy (NSPT), Minimally-Invasive Non-Surgical Therapy (MINST)
- Where
- Czechia
- Volunteers
- 106 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Periodontitis
Influence of Gum Disease Treatment on Long-term Dental Implant Success
The aim of this study is to evaluate the influence of periodontal care response on long term dental implant success. Investigator's hypothesis is that patients who do not well respond to periodontal care have more chance to…
- Trial name
- NCT03841656
- Testing
- PARORISKIMPLANT
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Periodontitis
Prevalence of Porphyromonas Gingivalis Fimbrial Subunit Genotype in Smokers and Nonsmokers After Periodontal Therapy
The aims of the present study will be identify 5 types of fimbrial subunit genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy.
- Trial name
- NCT02879903
- Testing
- Periodontal treatment, Microbiological collect, Questionnaire
- Volunteers
- 32 people
- Sponsor
- Universidade Federal Fluminense
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontitis, Depression
Impact of Periodontal Therapy on Mental Health Parameters
Objectives: Primary: To determine the efficacy of periodontal treatment on mental health outcomes in patients with major depression and periodontitis.
- Trial name
- LeakBrainRCT (NCT06036472)
- Testing
- Standard periodontal therapy (steps 1 & 2), supragingival debridement with anesthesia (step 1)
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Chronic Periodontitis
Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis
To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.
- Trial name
- NCT03043066
- Testing
- Scaling and root planing, scaling and root planing along with antibiotic intervention
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis, Clindamycin Gel
Comparing Aloe Vera Gel and Clindamycin Gel Added to Scaling and Root Planing for Periodontitis
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes…
- Conditions
- Periodontitis, Clindamycin Gel, Aloe Vera Gel, Scaling and Root Planing
- Trial name
- NCT07900802
- Testing
- Scaling and Root Planing
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
HIV/AIDS, Periodontal Diseases
Effects of Periodontal Treatment on HIV-infected Patients
Periodontal diseases, such as chronic periodontitis (CP), frequently occur in immunosuppressed patients, including HIV-infected patients.
- Trial name
- NCT03262402
- Testing
- Basic periodontal treatment
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Generalized Aggressive Periodontitis
Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic…
- Trial name
- NCT03933501
- Testing
- amoxicillin and metronidazole
- Volunteers
- 48 people
- Sponsor
- University of Campinas, Brazil
Periodontitis, Rheumatoid Arthritis
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis
Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum.
- Trial name
- NCT06245265
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Coronary Heart Disease, Periodontitis
Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
- Trial name
- NCT04305171
- Testing
- non-surgical periodontal treatment
- Where
- 3 sites in Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Periodontitis, Erectile Dysfunction
The Effects of Non -Surgical Periodontal Treatment on The Severity of Erectile Dysfunction
The aim of the present study is to study the influence of periodontal therapy (non-surgical) on the severity of erectile dysfunction(ED) among patients with chronic periodontitis and moderate or severe ED.
- Trial name
- NCT04129814
- Testing
- Non surgical periodontal therapy
- Volunteers
- 140 people
- Sponsor
- Taibah University
Chronic Kidney Disease Stage 5, Periodontitis
Effect of Non-surgical Periodontal Treatment and C-reactive Protein Levels in Hemodialysis Patients
The presence of periodontitis has been hypothesized as a risk factor for several systemic outcomes, including chronic kidney disease (CKD).
- Trial name
- NCT04262011
- Testing
- immediate treatment, postponed treatment
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Santa Maria
Periodontitis
Effect of Dietary Intake of Dried Whole Food Concentrates (Juice Plus) on Clinical Outcomes Following Periodontal Therapy: A Pilot Study
There are 3 hypotheses to be tested: 1. That daily supplementation with Juice Plus+ will significantly improve treatment outcomes over placebo supplementation, at 3-months post-therapy, when used as an adjunct to conventional…
- Trial name
- BHAM-NSA-05-01 (NCT00952536)
- Testing
- Daily Juice Plus+ with vegetable & fruit & berry capsule
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Birmingham Community Healthcare NHS
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
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