Clinical trials: Treatment of Periodontitis
Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis
Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial
The goal of this clinical trial is to learn whether probiotics, double antibiotic paste (DAP), or calcium hydroxide paste help reduce postoperative pain after root canal treatment in adults with symptomatic irreversible pulpitis.
- Conditions
- Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis, Pulpitis - Irreversible, Post Operative Pain, Acute
- Trial name
- NCT07270159
- Testing
- Probiotic
- Where
- Pakistan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Periodontitis, Diabetes Mellitus Type 2
PDT and Periodontal Treatment in DMT2 Patients
The relationship between diabetes mellitus (DM) and periodontal disease is bidirectional. DM is a predisposing and modifying factor of periodontitis, which, in turn, worsens glycemic control and increases proteins found in the…
- Trial name
- PDTDMT2 (NCT01964833)
- Testing
- Periodontal treatment, Periodontal treatment and PDT
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Nove de Julho
Apical Periodontitis
Comparative Analysis of Photodynamic Therapy on Periapical Healing
As a result of tooth decay, lesions caused by infection occur at the root tip. These teeth can heal with root canal treatment. In this study, additional applications will be made to increase the success of root canal treatment.
- Trial name
- NCT06553144
- Testing
- control, methylene blue, erythrosine b
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Gaziantep
Periodontitis
Periodontitis in Young Individuals, Follow up of Treatment and Disease Progression Over 10 Years
The general aim of this project is to get a better understanding how periodontitis develop in young individuals over time and identify factors that contribute to disease recurrence.
- Trial name
- NCT04926519
- Testing
- Type of periodontal treatment
- Where
- Sweden
- Volunteers
- 471 people
- Sponsor
- Folktandvården Stockholms län AB
Intracanal Medicament
Comparison of Inter-appointment Pain Reduction During Root Canal Treatment in Symptomatic Apical Periodontitis by Using Intracanal Medicaments; Chlorhexidine Gel and Single Antibiotic Paste Nitrofurantoin
This study is being conducted to find out which of two medications-Chlorhexidine Gel or Nitrofurantoin-works better in reducing pain between root canal treatment visits.
- Trial name
- NCT07198919
- Testing
- Chlorhexidine gel, Nitrofurantoin 100 MG
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Altamash Institute of Dental Medicine
Chronic Periodontitis
Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
- Trial name
- NCT05759416
- Testing
- Melatonin2%gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontal Diseases
Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Hypothesis: There will be an additional reduction of pocket depth and gain of clinical attachment when dehydrated human amnion-chorion membrane (dHACM) is placed into the periodontal disease defect after mechanical scaling and…
- Trial name
- NCT03836378
- Testing
- BioXclude™
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Periodontitis, Probiotics
Effects of Probiotic Therapy in the Treatment of Periodontitis.
The aim of this study is to evaluate the effect of the probiotic therapy as an adjunct to non-surgical periodontal treatment in patients diagnosed with Generalized Chronic Periodontitis.
- Trial name
- NCT03408548
- Testing
- Scaling root planning, Probiotic
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Sao Paulo
Post Operative Pain, Post-Op Complication
Effect of Occlusal Reduction on Relief of Pain and Sensitivity to Percussion in Patients With Irreversible Pulpitis
One of the most important aspects of endodontic practice is to abate pain during and post root canal treatment. An endodontist by all means should provide a painless endodontic treatment to their patients.
- Trial name
- NCT05306535
- Testing
- Occlusal reduction
- Where
- Pakistan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Chronic Periodontitis, Periodontal Pocket
Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis
Chronic periodontitis is an inflammatory and polymicrobic disease characterized by the irreversible loss of alveolar bone and connective tissue attachment of the teeth.
- Conditions
- Chronic Periodontitis, Periodontal Pocket, Periodontal Attachment Loss, Periodontal Diseases
- Trial name
- NCT04082949
- Testing
- autologous fibrin glue application as an adjunct to nonsurgical periodontal treatment of chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Inonu University
Chronic Periodontitis
Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of Nano-crystalline hydroxyapatite silica gel in comparison with open flap debridement for management of periodontal intrabony defects.
- Trial name
- NCT02507596
- Testing
- Nano-crystalline hydroxyapatite silica gel, open flap debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Periodontal Diseases
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
This study is meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with papilla preservation flap versus papilla…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket, Intrabony Periodontal Defect
- Trial name
- NCT03588507
- Testing
- PPF+NCHA bone graft substitute
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Advanced Platelet-Rich Fibrin Plus in Nonsurgical Periodontal Therapy
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to…
- Trial name
- NCT07782736
- Testing
- Scaling and Root Planing, Advanced Platelet-Rich Fibrin Plus
- Where
- Vietnam
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periodontitis, Smoking ( Cigarette)
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis.
- Trial name
- NSPT-Biomarker (NCT07547202)
- Testing
- Non-surgical periodontal therapy (Scaling and root planing)
- Where
- 2 sites in Iraq
- Volunteers
- 44 people
- Sponsor
- Al-Mustansiriyah University
Chronic Periodontitis
Efficacy of a Probiotic Lozenges in Chronic Periodontitis Patients.
Periodontal disease is an infectious disease resulting in inflammation within supporting tissues of the teeth, progressive attachment loss, and bone loss.
- Trial name
- NCT02121665
- Testing
- Probiotic (Inersan)
- Where
- India
- Volunteers
- 42 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Teeth, Endodontically-Treated, Tooth, Nonvital
Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair
This is a randomized, prospective, double-blind, controlled clinical trial designed to evaluate 3 distinct clinical approaches used during endodontic therapy: Group 1- Root canal treatment in single visit (RCT-SV); Group 2- Root…
- Conditions
- Teeth, Endodontically-Treated, Tooth, Nonvital, Periapical Periodontitis, Chronic Nonsuppurative, Periapical Granuloma
- Trial name
- NCT05256667
- Testing
- RCT-SV, RCT-TVWD, RCT-TVWOD
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- New York University
Periodontitis
Effects of Azithromycin as an Adjunct to Scaling and Root Planning in the Treatment of Periodontitis
The growing interest in the possibilities of modulating macrophages in inflammatory diseases with therapeutic purpose has prompted the development of new approaches for the treatment of periodontitis.
- Trial name
- NCT05506371
- Testing
- Az+SRP, SRP, No interventions
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ukrainian Medical Stomatological Academy
Obesity, Periodontitis
Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis
Our objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of vaspin and omentin in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02563171
- Testing
- non surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Periodontitis
Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment
The goal of this clinical trial is to assess the safety and effectiveness of adjunctive Emdogain® therapy in non-surgical periodontal treatment for patients with stage 3 and 4 periodontitis.
- Trial name
- NCT06070181
- Testing
- Enamel matrix derivate, Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Ostergotland County Council, Sweden
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