Clinical trials: Treatment of Periodontitis
Periodontal Diseases, Periodontitis
Healthy Plant-based Diet and Periodontal Treatment
Background: Periodontitis is a highly prevalent chronic disease, affecting around 743 million people globally. In Hong Kong, over 90% of adults have bleeding gums, and 50% of the elderly have severe periodontitis.
- Conditions
- Periodontal Diseases, Periodontitis, Diet
- Trial name
- NCT06753682
- Testing
- Healthy Plant Based Diet
- Where
- Hong Kong
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Type 2 Diabetes, Halitosis
Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus
The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), in…
- Conditions
- Type 2 Diabetes, Halitosis, Periodontitis
- Trial name
- NCT07463859
- Testing
- Scaling and root planing, Photodynamic Therapy with Conventional Methylene Blue
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo
Periapical Abscess
"Is Antibiotic Therapy Necessary for Patients Undergoing Extraction of Teeth With Abscess?"
This is a triple-blind randomized controlled trial conducted at the Department of Oral and Maxillofacial Surgery, Subbaiah Institute of Dental Sciences, Shimoga.
- Trial name
- NCT07694531
- Testing
- Amoxicillin 500mg
- Where
- India
- Volunteers
- 176 people
- Sponsor
- Subbaiah Institute of Dental Sciences
Hemophilia A and B, Periodontitis
Effect of Non-Surgical Periodontal Treatment on Oral Health in Hemophilia Patients
This study aimed to evaluate the effect of non-surgical periodontal treatment (NSPT) on oral health-related quality of life in patients with hemophilia using the Oral Health Impact Profile-14 (OHIP-14) questionnaire.
- Conditions
- Hemophilia A and B, Periodontitis, Hemophilia
- Trial name
- NCT07691437
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Periodontitis, Coronariopathy
Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies
Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization.
- Trial name
- NCT02150005
- Testing
- Periodontal treatment
- Volunteers
- 22 people
- Sponsor
- Universidade Veiga de Almeida
Periodontitis
Enamel Matrix Derivative in Non-surgical Periodontal Treatment
The aim of the study is to investigate the effect of enamel matrix derivative in addition to scaling and root planing in comparison to scaling and root planing only in periodontitis patients that have already undergone initial…
- Trial name
- NCT04449393
- Testing
- Emdogain® FL, Scaling and root planing
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Vienna
Apical Periodontitis
Comparative Analysis of Photodynamic Therapy on Periapical Healing
As a result of tooth decay, lesions caused by infection occur at the root tip. These teeth can heal with root canal treatment. In this study, additional applications will be made to increase the success of root canal treatment.
- Trial name
- NCT06553144
- Testing
- control, methylene blue, erythrosine b
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Gaziantep
Dental Caries in Children, Dental Plaque
Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases
The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can…
- Conditions
- Dental Caries in Children, Dental Plaque, Tooth Decay, Periodontitis
- Trial name
- LumoPrevent (NCT06286501)
- Testing
- Lumoral Treatment, Standard, personalized oral health care
- Where
- Finland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wellbeing Services County of Pirkanmaa
Obesity, Periodontitis
Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis
Our objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of vaspin and omentin in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02563171
- Testing
- non surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Dental Pulp Necroses, Apical Periodontitis
Effects of Intracanal Cryotherapy on Endodontic Postoperative Pain
The goal of this clinical trial is to evaluate the effect of cold saline (2.5 degrees Celsius) irrigation on postoperative pain in patients who require root canal treatment in molar teeth because of dead dental pulp and infection…
- Conditions
- Dental Pulp Necroses, Apical Periodontitis, Post Operative Pain
- Trial name
- NCT05611736
- Testing
- cold saline, saline
- Where
- Saudi Arabia
- Volunteers
- 302 people
- Sponsor
- Qassim University
Periodontitis
Evaluation of Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non Surgical Therapy
Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status.
- Trial name
- ENLPPMNS (NCT02357745)
- Testing
- Non surgical periodontal therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontal Bone Loss
Application of Hyaluronic Acid in the Treatment of Periodontitis
The aim of the present investigation will be evaluated the healing of suprabony defects following surgical flap elevation and hyaluronic acid application respect to surgical flap elevation alone.
- Trial name
- NCT05073575
- Testing
- Hyaluronic acid, No-hyaluronic acid
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontitis, Periodontitis (Stage 3)
Minimally Invasive Non-Surgical Periodontal Treatment
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy…
- Trial name
- NCT07755644
- Testing
- Minimally Invasive Non-Surgical Therapy (MINST), Conventional Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Ataturk University
Periodontitis
Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis
The aim of the study was to assess the effect of nitazoxanide delivered subgingivally as thermosensitive hydrogel on the clinical and biochemical outcomes of SRP in patients with moderate periodontitis.
- Trial name
- NCT04768530
- Testing
- Scaling and Root Planing, Nitazoxanide hydrogel
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Maha Talaab
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontal Diseases
Periostin and Non-Surgical Periodontal Treatment
A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment.
- Trial name
- NCT04332965
- Testing
- Non-Surgical Periodontal Treatment
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Generalized Aggressive Periodontitis, Aggressive Periodontitis
Alternative Antibiotic Regime in the Treatment of GAgP
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized…
- Trial name
- NCT02223702
- Testing
- Amoxicillin, Metronidazole, Moxifloxacin
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Vitamin D Deficiency
Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients
Clinical Comparative Evaluation of the use of Photodynamic Therapy in conjunction with the use of Vitamin D in management Stage II Grade B Periodontitis Patients: A Randomized controlled clinical trial.
- Trial name
- NCT06700122
- Testing
- non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Type 2 Diabetes Mellitus
Effect of Non-surgical Periodontal Treatment on HbA1c in Type 2 Diabetic Patients
The main objective is to evaluate the effect of nonsurgical periodontal treatment on serum levels of HbA1c in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02652026
- Testing
- Nonsurgical periodontal treatment, Dental Prophylaxis
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontitis
A Clinical Trial to Evaluate the Effectiveness of Lactobacillus Reuteri for Periodontitis in a Chinese Population
The aim of this study is to determine the efficacy of application of Lactobacillus Reuteri probiotics therapy on clinical improvement and on microbial shift in Chinese periodontitis patients.
- Trial name
- NCT04129684
- Testing
- Probiotics
- Where
- China
- Volunteers
- 880 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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