Clinical trials: Treatment of Periodontitis
L-PRF, Photodynamic Therapy
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria.
- Conditions
- L-PRF, Photodynamic Therapy, Aggressive Periodontitis
- Trial name
- NCT05043935
- Testing
- L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Asymptomatic Apical Periodontitis, Root Canal Infection
Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis
This randomized controlled clinical trial aimed to evaluate the effect of sonic activation using the EDDY device on root canal microbiota and postoperative pain in teeth with asymptomatic apical periodontitis.
- Conditions
- Asymptomatic Apical Periodontitis, Root Canal Infection, Periapical Diseases, Dental Pain
- Trial name
- NCT07120126
- Testing
- EDDY Sonic Activation, Conventional Syringe Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Abdulkadir Tiftik,DDS
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Periodontal Pocket
The Efficacy of Salvia Officinalis Gel in the Treatment of Periodontitis CLINICAL TRIAL
From each participant, two sites of periodontal pockets ( ≥ 5 mm ) were selected and randomly allocated to either the test site (treated with scaling and RSD with S.
- Trial name
- clinical (NCT06900517)
- Testing
- Salvia officinalis Gel
- Volunteers
- 23 people
- Sponsor
- University of Baghdad
Periodontitis
Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis
This study is to determine whether scaling and root planning (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with…
- Trial name
- NCT00297518
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ondine Research Laboratories
Chronic Periodontitis, Generalized
Flapless Emdogain in the Treatment of Periodontal Residual Pockets
48 adult patients participated in a single-centre randomized clinical trial with split- mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for…
- Trial name
- NCT05823389
- Testing
- Re-instrumentation with flapless Emdogain application
- Where
- Palestinian Territories
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Coronary Heart Disease, Periodontitis
Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing
The purpose of this study is to determine whether scaling and root planing as a periodontal intervention helps in improving the overall health of patients suffering from coronary heart disease.
- Trial name
- NCT02417376
- Testing
- piezoelectric ultrasonic scaler (frequency of 28-36 KHz), Gracey curettes
- Volunteers
- 70 people
- Sponsor
- Government College of Dentistry, Indore
Periodontitis
Application of CIELab Spectrophotometry to Analyze Gingival Color: a New Perspective for Evaluating the Effectiveness of Periodontal Basic Treatment
Objective: This study aims to explore the correlation between gingival color and clinical indicators and inflammatory factors in patients with periodontitis.
- Trial name
- NCT06698718
- Testing
- Periodontal basic treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontitis
The Use of a Probiotic Lozenge in the Treatment of Residual Pockets After Classical Non-surgical Therapy
The aim of this study is to determine the efficacy of the usage of a probiobitc lozenge in patients with residual bleeding pockets of ≥ 5mm 3 months following scaling and rootplaning.
- Trial name
- NCT02490618
- Testing
- Probiotic tablet- Biogaia
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Apical Periodontitis
Effect of Different Instrumentation Technique on Endodontic Outcome
Aim: To evaluate and compare the outcome of primary endodontic treatment following use of different instrumentation techniques. Materials and methods: Study subjects were recruited from the pool of patients referred for the…
- Trial name
- NCT03278054
- Testing
- Root Canal Treatment with hand instruments, Root canal treatment with Protaper instruments, Root canal treatment with hybrid instrumentation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Apical Periodontitis
Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis
This randomized, controlled, double-blinded clinical trial aims to directly compare the efficacy of Sonically Activated Irrigation (SAI) versus Passive Ultrasonic Irrigation (PUI) in the root canal treatment of teeth with chronic…
- Trial name
- NCT07069881
- Testing
- Sonic-Activated Irrigation, Passive Ultrasonic Irrigation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Periodontitis, Furcation Defects
Efficacy of PRF and Xenograft in Treating Mandibular Molar Furcation Involvements
The purpose of this randomized controlled clinical trial is to compare the effectiveness of advanced platelet-rich fibrin (A-PRF+) combined with xenograft versus a collagen membrane combined with xenograft in the treatment of…
- Trial name
- NCT07764029
- Testing
- A-PRF+ and Xenograft, Collagen Membrane and Xenograft
- Where
- Vietnam
- Volunteers
- 22 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Peri-implantitis, Periodontitis
Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis
This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients…
- Conditions
- Peri-implantitis, Periodontitis, Non-surgical Periodontal Therapy
- Trial name
- MINST vs NSPT (NCT07466966)
- Testing
- Non-Surgical Peri-implant Therapy (NSPT), Minimally-Invasive Non-Surgical Therapy (MINST)
- Where
- Czechia
- Volunteers
- 106 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Periodontal Diseases
Treatment of Advanced Periodontitis Using an Oscillating Chitosan Device Versus Regular Curettes Alone
40 patients diagnosed with localised periodontitis will be included at each center, 20 patients will be treated with the control treatment, 20 patients will be treated by test treatment.
- Trial name
- NCT04173156
- Testing
- Labrida Bioclean, Gracey Periodontal curettes
- Where
- 3 sites in Norway, Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Labrida AS
Periodontitis
Evaluation of the Effects of Immune Cells on Periodontal Healing
Periodontitis is an inflammatory disease with an infectious character, where, as the result of the host response to a dysbiotic microflora, attachment and bone loss occur.
- Trial name
- EMTA (NCT04792372)
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Biruni University
Periodontitis
Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress
This study began enrollment in 2003 with final report completed in October of 2015. This submission is being provided to acquire an NCT number.
- Trial name
- BCU2 (NCT03375372)
- Testing
- Scaling and Root Planing (S&RP)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Risk Markers, Chronic Periodontitis
Non-surgical Peridontal Treatment on Cardiovascular Risk Markers
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
- Trial name
- NCT04540328
- Testing
- Non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontitis
Conservative Surgery with Modified Widman Flap Vs Papilla Preservation Technique for the Treatment of Residual Pockets
The primary aim of the study is to evaluate the efficacy of conservative surgery with or without papilla preservation technique in the treatment of deep residual pockets ≥ 6 mm in stage III-IV periodontitis patients after cause…
- Trial name
- MWF vs PPT (NCT06661928)
- Testing
- Papilla preservation flap, Widman flap procedure
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Aloe Vera in Chronic Periodontitis With Type 2 Diabetes Mellitus
The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes…
- Trial name
- NCT02386020
- Testing
- aloe vera
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
- Trial name
- NCT07261878
- Testing
- injectable platelet rich fibrin and xenograft, Xenograft alone
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
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