Clinical trials: Treatment of Periodontitis
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Chronic Periodontitis, Diabetes Type 2
Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2
This study will evaluate if periodontal mechanical treatment is capable to alter immunological and genetical parameters related to systemic health in patients with chronic periodontitis ant diabetes type 2.
- Trial name
- NCT02589314
- Testing
- Mechanical periodontal therapy, nonsurgical periodontal therapy
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Periodontitis
Predictive Role of the Full-mouth Plaque Score on the Outcomes of Non-surgical Periodontal Therapy.
Oral hygiene quality is a key determinant of outcomes in both non-surgical and surgical periodontal therapy. Previous studies have demonstrated the negative impact of site-specific plaque accumulation on periodontal parameters.
- Trial name
- NCT07524504
- Testing
- Non-surgical periodontal therapy (NSPT)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Chronic Periodontitis Complex
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics.
- Trial name
- NCT03692819
- Testing
- Amoxicillin 500 Mg, Lactobacillus reuteri Oral Drops
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontitis, Periimplantitis
MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery
This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3)…
- Trial name
- MICROSURG (NCT07414498)
- Testing
- Resective Periodontal Surgery, Regenerative Periodontal Surgery, Surgical Peri-implantitis Therapy
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University Hospital Muenster
Periodontitis, Periodontal Diseases
Effect of Smoking and Periodontal Therapy on Salivary and Gingival Crevicular IL-17 and IL-35
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response.
- Conditions
- Periodontitis, Periodontal Diseases, Smoking, Smoking, Tobacco
- Trial name
- NCT05281848
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Smokers
This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients
This study is a randomized, controlled, split-mouth clinical trial designed to evaluate and compare the effectiveness of four different subgingival adjuncts used along side standard Scaling and Root Planning (SRP).
- Conditions
- Periodontitis, Smokers, Non Smokers, Periodontal Disease
- Trial name
- NCT07707063
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%)
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Periodontitis, Stage IV Periodontitis
Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV Periodontitis
Conventional periodontal treatment typically involves a combination of non-surgical and surgical approaches, such as scaling and root planing, followed by flap surgery and guided tissue regeneration.
- Conditions
- Periodontitis, Stage IV Periodontitis, Minimally Invasive Treatment, Splints
- Trial name
- NCT06772506
- Testing
- Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%), Minimally invasive non-surgical technique with mini five and after five minimally invasive instrument plus splint
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Periodontal Diseases
TREM-1 Pathway in Predicting Treatment Outcomes in Periodontitis
This study investigated modulations in salivary triggering receptor expressed on myeloid cells (TREM)-1, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)-1β levels between healthy, gingivitis and periodontitis…
- Trial name
- NCT06715176
- Testing
- Clinical periodontal measurements at baseline (T0), Saliva collection at baseline (T0), Scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis Complex, Xenograft Model
Papillae Tunneling Techniques in the Treatment of Isolated Intrabony Defects
Papillae tunneling techniques (PTT) are a new approach toward regeneration of isolated intrabony defects. Compared to regular papillae preservation techniques, PTT rely on complete preservation of involved interdental papillae…
- Trial name
- PTT (NCT04782921)
- Testing
- Xenogenic bone graft material
- Where
- 2 sites in Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Ljubljana
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Periodontitis
Air Polishing as an Adjunct in Non-surgical Periodontal Therapy
Periodontal disease is an infection that causes inflammation and destruction of the tooth supporting structures, and if untreated, will eventually lead to tooth loss.
- Trial name
- NCT04178291
- Testing
- Ultrasonic scaler and Gracey currettes, Air polishing with erythritol powder
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Periodontitis
Effect of Menstrual Cycle Phase on Pain Perception and Anxiety During Non-Surgical Periodontal Treatment
This study evaluates the effect of menstrual cycle phases on pain perception and dental anxiety during non-surgical periodontal therapy in premenopausal women with Stage II and III periodontitis.
- Trial name
- MAPP (NCT07719686)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Karadeniz Technical University
Combat and Operational Stress Reaction
Role of Stress Reduction Protocol on Outcome of Periodontal Therapy
Psychological conditions, particularly psychosocial stress, have been implicated as risk indicators for periodontal disease. Minimal evidence in literature exists to assess the effect of stress reduction therapy (SRT) in the…
- Trial name
- NCT02487862
- Testing
- Stress Reduction Protocol
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Diseases
Autologous Platelet Concentrate (APC) in Intrabony Defects
The aim of this 12-month clinical study is to treat patients affected by gum disease (periodontitis) by a minor gum surgery that aims to reduce the depth of the gum pockets.
- Trial name
- NCT04254861
- Testing
- Simplified Papilla Preservation Flap (SPPF) and PRGF ENDORET (PRGF ENDORET®-KMU16), Simplified Papilla Preservation Flap (SPPF) and GTR
- Where
- United Kingdom
- Volunteers
- 74 people
- Sponsor
- Queen Mary University of London
Periodontitis, Regeneration
Modified Entire Papilla Preservation Technique For Treatment Of Intrabony Defects. Clinical Trial.
Regeneration of periodontal tissues is the primary goal of periodontal surgery regenerative procedures. Most techniques include an incision of the interdental papilla associated with defect.
- Trial name
- MEPPT (NCT05029089)
- Testing
- Modified Entire Papilla Preservation Technique (MEPPT) For Periodontal Regenerative Treatment Of Intrabony Defects., Emdogain (EMD), Biomaterials (allograft, subepithelial connective tissue graft/sCTG), Modified Entire Papilla Preservation Technique (MEPPT) with Emdogain For Periodontal Regenerative Treatment Of Intrabony Defect
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Chronic Apical Periodontitis
The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels.
Chronic apical periodontitis is a chronic inflammatory condition characterized by periapical tissue destruction and alveolar bone resorption as a result of the host response to pulpal infection, often presenting asymptomatically.
- Trial name
- NCT07542223
- Testing
- single nucleotide polymorphism
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ataturk University
Periodontal Diseases
Effect of Internal and External Micro-needling in Treatment of Stage III Periodontitis
Periodontitis is a dysbiotic disease characterized by the destruction of the periodontium (alveolar bone, cementum, periodontal ligament, gingiva) and considered the main cause of tooth loss which is linked to a change in the…
- Trial name
- NCT06578403
- Testing
- external microneedling, minimally invasive non- surgical periodontal therapy, internal micro_needling
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Periodontal Intrabony Defects, Stage III Grade B Periodontitis
Sub-junctional Pinhole Technique
Pinhole Regenerative Therapy (PRT) following minimally invasive non-surgical periodontal therapy (MINST) in the treatment of intrabony defects associated with Stage III Grade B periodontitis.
- Trial name
- PRT (NCT07763223)
- Testing
- Sub-junctional Pinhole Technique (S-PHT)
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Post Operative Pain, Inflammation
Clinical and Biochemical Effects Of Cryotherapy Protocols On Mandibular Premolars With Symptomatic Apical Periodontitis
Pain is the major reason for patients' visits to dental clinics.Medications have side effects. Treatments including cryotherapy have been suggested to prevent these side effects.This study will compare the effect of oral and…
- Trial name
- NCT07138365
- Testing
- oral Cryotherapy, Intra radicular Cryotherapy, cold irrigation
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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