Clinical trials: Treatment of Periodontitis
Inflammatory Disease, Periodontal Diseases
Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis
Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth.
- Trial name
- NCT05546788
- Testing
- scaling and root planing, hydroxylated poly methoxy flavones, chlorhexidine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontitis
Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
ABSTRACT: Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which releases various growth factors that promote tissue regeneration.
- Trial name
- NCT02283554
- Testing
- open flap debridement (OFD), Platelet rich fibrin (PRF), Metformin
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Disease
Periodontal Treatment Associated With Hyperbaric Oxygen Therapy
Evaluation of the clinical effect of hyperbaric oxygen therapy (HBOT) adjunctively to scaling and root planing (SRP) in the treatment of severe case of chronic periodontitis.
- Trial name
- NCT00955643
- Testing
- oxygen, other
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Escola Bahiana de Medicina e Saude Publica
PERIAPICAL LESIONS
Effect of NSRCT on HbA1c and Inflammatory Markers in Healthy and Type 2 Diabetes Patients With Apical Periodontitis
To the best of knowledge, only 2 prospective studies, and 1 cross-sectional study have been reported which have seen the periapical healing after non surgical endodontic treatment in diabetic patients and their effect on HbA1c.
- Trial name
- NCT05609747
- Testing
- Nonsurgical root canal therapy
- Where
- 2 sites in India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis
Comparison of Moxifloxacin With Ciprofloxacin/Metronidazole on Patients With Chronic Periodontitis
The purpose of this study is to assess the clinical and microbiological effectiveness of the moxifloxacin compared with the combination ciprofloxacin - metronidazole, when used as adjunctive therapy to scaling and root planning…
- Trial name
- NCT00805558
- Testing
- moxifloxacin, Ciprofloxacin plus metronidazole
- Where
- Colombia
- Volunteers
- 76 people
- Sponsor
- Facultad Nacional de Salud Publica
Periodontitis, Probiotic
Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis
Most previous studies have evaluated standardized probiotic regimens as adjuncts to NSPT (Ausenda et al., 2023; Hardan et al., 2022; Mauriello et al., 2025).
- Conditions
- Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
- Trial name
- NCT07619040
- Testing
- non surgical periodontal therapy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Medipol University
Aggressive Periodontitis, Generalized
Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis
The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin…
- Trial name
- NCT03132714
- Testing
- Full-mouth ultrasonic debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Motivational Interviewing, Periodontitis
Motivational Interviewing and Subgingival Instrumentation Outcomes in Periodontitis
Motivational Interviewing (MI) represents a patient centered counselling approach designed to facilitate behaviour change by guiding patients through the exploration and resolution of ambivalence toward positive health actions.
- Conditions
- Motivational Interviewing, Periodontitis, Oral Hygiene
- Trial name
- NCT07618533
- Testing
- Motivational Interviewing, Oral hygiene instructions
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis
Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT03204058
- Testing
- Rosuvastatin, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontitis Chronic Generalized Severe
Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis
the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III…
- Trial name
- NCT05768243
- Testing
- Hyaluronic acid, red injectable platelet rich fibrin (i-prf)
- Where
- Lebanon
- Volunteers
- 75 people
- Sponsor
- Beirut Arab University
Periodontitis, Diabetes
Effect of Non Surgical Treatment of Periodontitis on Diabetes Control
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients.
- Trial name
- PARODIA1 (NCT02745015)
- Testing
- non-surgical periodontal treatment
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- Yaounde Central Hospital
Periodontitis, Adult, Periodontal Pocket
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant.
- Conditions
- Periodontitis, Adult, Periodontal Pocket, Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT03453476
- Testing
- SRP and Fotosan 630
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Chronic Periodontitis, Smoking, Cigarette
GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis
This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant…
- Trial name
- GCF (NCT04115176)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Periodontitis
The Effect of Time on the Outcome of Periodontal Treatment.
Re-evaluation after non-surgical periodontal treatment remains an integral part of comprehensive periodontal therapy. This re-evaluation determines if a patient is in need either of surgical periodontal therapy or a personalized…
- Trial name
- NCT05643287
- Testing
- Periodontal treatment
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- 251 Hellenic Air Force & VA General Hospital
Oral Hygiene, Photographs
Effect of Pre-treatment Photographs on Oral Hygiene Maintenance in Orthodontic Patients
Dental photography is an essential component of orthodontic treatment. Photographs enable the clinician to keep record of different stages of treatment.
- Trial name
- NCT06010797
- Testing
- Showing Pre-treatment photographs of the patient
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehmat Memorial Post Graduate Dental Teaching Hospital
Periodontitis
Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss.
- Trial name
- NCT05583643
- Testing
- Atorvastatin Calcium, Scaling and debridement only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
- Trial name
- NCT07261878
- Testing
- injectable platelet rich fibrin and xenograft, Xenograft alone
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis
Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study.
This research aims to evaluate the effectiveness of intentional replantation (IR) as a treatment for single-rooted teeth diagnosed as hopeless due to true periodontic lesions.
- Trial name
- NCT06893107
- Testing
- Intentional Replantation
- Where
- United Arab Emirates
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Fujairah
Root Canal Treatment, Postoperative Pain
Different Kinematics Within a Single-File System and Postoperative Pain
The goal of this clinical trial is to evaluating the influence of single file rotary system for root canal instrumentation using different kinematics on postoperative pain, the primary purpose: measuring post-operative pain by…
- Conditions
- Root Canal Treatment, Postoperative Pain, Apical Periodontitis
- Trial name
- NCT07699432
- Testing
- Twisted Adaptive motion (TFA), canal pro jeni, forward reciprocation
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
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