Clinical trials: Treatment of Periodontitis
Periodontitis
Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis
Comparing the effect of using vitamin C with injectable PRF as a locally delivered adjunct to scaling and root planing versus scaling and root planing with local delivery of injectable PRF and scaling and root planing alone on…
- Trial name
- NCT05129267
- Testing
- Group B, Group C
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Periodontal Disease
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging
- Trial name
- NCT06677736
- Testing
- conventional scaling and debridement, Diode laser as adjunctive to conventional scaling and debridement
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Rawda Saleh Saad Alashmawy
Irreversible Pulpitis, Apical Periodontitis
Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis
Statement of problem: Although performing full pulpotomy in mature permanent molars with irreversible pulpitis showed success rates comparable to RCT, there is a growing need for further studies in order to determine the…
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpitis
- Trial name
- NCT06767371
- Testing
- Patients with mature permanent molars diagnosed with severe pulpitis with apical periodontitis to be treated with full pulpotomy., Patients with mature permanent molars diagnosed with moderate pulpitis without apical periodontitis to be treated with full pulpotomy., Teeth with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Misr International University
Smoking ( Cigarette), Periodontitis Stage II
Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning
The aim of this study is to evaluate how smoking affects the healing process of the gums after treatment. The researchers will measure the levels of two specific proteins (PLAP-1 and Sclerostin) in the gum fluid of patients with…
- Trial name
- NCT07339670
- Testing
- Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Al-Azhar University
Periodontal Pocket
Evaluation of Endodontic Status on Periodontal Healing of Concomitant Endodontic Periodontal Lesions
Introduction: To evaluate the effect of untreated endodontic infection on periodontal status in untreated non vital teeth with periapical radiolucency as compared to contralateral vital teeth.
- Trial name
- NCT02630173
- Testing
- Scaling and root planing, Endodontic treatment
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis
Impact of Periodontal Therapy on Function and Quality of Life in Stage III Periodontitis
Stage III, Grade B periodontitis is a severe form of gum disease that damages the tissues and bone supporting the teeth. It can cause loose teeth, difficulty chewing, and reduced quality of life.
- Trial name
- NCT07450573
- Testing
- non-surgical periodontal treatment, surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Periodontitis, Hypertension
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis.
- Conditions
- Periodontitis, Hypertension, TNF Alpha, Endocan
- Trial name
- NCT06627192
- Testing
- NSPT, clinical and biochemical assesment
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
The Effect of A-PRF+ Versus Open Flap Debridement in the Treatment of Patients With Stage III Periodontitis
To assess the effectiveness of advanced PRF+ as compared to open flap debridement in treatment of periodontal intraosseous defects in stage III periodontitis patients.
- Trial name
- NCT03924336
- Testing
- Advanced- platelets rich fibrin (A-PRF+) + Open flap debridement (OFD), Open flap debridement (OFD) alone
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Diabetes Mellitus, Type 2
Clinical and Microbiological Evaluation of Periodontal Treatment of Diabetic Patients: A Longitudinal Study
The purpose of this study is to determine whether periodontal treatment improves the periodontal clinical parameters in the periodontal patients with diabetes regarding non-diabetics: two years follow-up.
- Trial name
- NCT02643771
- Testing
- Full Mouth Scaling and Root Planing
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Eduardo Aleixo Figueira
Periodontitis
Enamel Matrix Derivative in Non-surgical Periodontal Treatment
The aim of the study is to investigate the effect of enamel matrix derivative in addition to scaling and root planing in comparison to scaling and root planing only in periodontitis patients that have already undergone initial…
- Trial name
- NCT04449393
- Testing
- Emdogain® FL, Scaling and root planing
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Vienna
Periodontitis
Caffeine Intake and Periodontal Treatment Outcomes
This study will explore whether caffeine intake can affect recovery after periodontal (gum) treatment. Periodontitis is a common gum disease caused by bacteria.
- Trial name
- NCT07747545
- Testing
- No Caffeine Intake, Low Caffeine Intake, Moderate Caffeine Intake
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Haoran Feng
Periodontitis, Periodontitis (Stage 3)
Effect of Guided Biofilm Therapy in Patients With Stage 3 Periodontitis
This randomized interventional study aims to compare the clinical and biochemical effects of conventional non-surgical periodontal therapy (NSPT), adjunctive diode laser therapy, and guided biofilm therapy (GBT) in patients with…
- Trial name
- NCT07788937
- Testing
- Non-Surgical Periodontal Therapy, Diode Laser Therapy, Guided Biofilm Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Chronic Periodontitis
Evaluation of SilOss® in Periodontal Surgery
Siloss® (Azurebio, Madrid, Spain) is a synthetic and inorganic bone graft material and is composed of a dicalcium phosphate anhydrous (monetite), hydroxyapatite (HA), and amorphous silica and trace amounts of zinc.
- Trial name
- NCT02639572
- Testing
- Siloss® bone graft, Hydroxyapatitie Bone graft
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontal Diseases, Biomarkers
Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid
Objectives: Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG).
- Conditions
- Periodontal Diseases, Biomarkers, Bone Resorption
- Trial name
- NCT03787875
- Testing
- periodontal treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Periodontal Intrabony Defect
Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
clinical trial was conducted to evaluate regenerative potentials of cultured gingival fibroblasts and GMSCs carried in beta tri calcium phosphate scaffold into intrabony periodontal defects in human by clinical and radiographic…
- Trial name
- NCT03638154
- Testing
- GF+GMSCs carried on β TCP, β TCP bone substitute only
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis, Therapeutics
Omega-3 Polyunsaturated Fatty Acids in Non-surgical Treatment of Periodontitis
Periodontitis is a chronic multifactorial inflammatory disease that lead to the loss of supportive tissues around the teeth with gradual deterioration of masticatory function and esthetics, resulting eventually in the decrease of…
- Conditions
- Periodontitis, Therapeutics, Fatty Acids, Unsaturated
- Trial name
- NCT04477395
- Testing
- fish oil, SRP only
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Periodontitis, Menopause
Evaluation of Periodontal Response to Non Surgical Therapy in Pre and Post Menopausal Women With Periodontitis
The present study was evaluated periodontal status in pre and post-menopausal women with periodontitis following non-surgical therapy.
- Conditions
- Periodontitis, Menopause, Plaque, Inflammation
- Trial name
- EPRNPPMP (NCT02718014)
- Testing
- scaling and root planing (srp)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis, Periodontitis (Stage 3)
Minimally Invasive Non-Surgical Periodontal Treatment
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy…
- Trial name
- NCT07755644
- Testing
- Minimally Invasive Non-Surgical Therapy (MINST), Conventional Scaling and Root Planing
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Ataturk University
Chronic Periodontitis, Type2 Diabetes
1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus
The purpose of the present study was to evaluate the effects of subgingival delivery of 1.2% Rosuvastatin (RSV) gel as an adjunct to scaling and root planing in chronic periodontitis (CP) with Type 2 diabetes mellitus patients.
- Trial name
- NCT02985099
- Testing
- SRP plus Rosuvastatin gel
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
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