Clinical trials: Treatment of Periodontitis
Periodontitis, Treatment Adherence
I-Smads in Periodontitis
Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation.
- Trial name
- NCT04846166
- Testing
- Periodontally healthy group, Periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Symptomatic Apical Periodontitis, Postoperative Pain
Photobiomodulation After Nonsurgical Root Canal Treatment
This randomized, double-blind controlled clinical trial will evaluate whether adjunctive photobiomodulation improves recovery after nonsurgical root canal treatment in adults with teeth diagnosed with symptomatic apical…
- Conditions
- Symptomatic Apical Periodontitis, Postoperative Pain, Mechanical Allodynia
- Trial name
- NCT07886723
- Testing
- Adjunctive Photobiomodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Chronic Periodontitis, Generalized, Gingivitis
Measurement of Oncostatin M, Leukemia Inhibitory Factor and Interleukin-11 Levels of Patients With Periodontal Disease
This study aims to determine Oncostatin M (OSM), Leukemia inhibitory factor (LIF), and Interleukin-11 (IL-11) levels in gingival crevicular fluid (GCF), saliva, and serum in periodontally healthy individuals and those with…
- Trial name
- NCT04597073
- Testing
- Initial Periodontal Therapy
- Volunteers
- 72 people
- Sponsor
- Ataturk University
Periodontitis
Application of CIELab Spectrophotometry to Analyze Gingival Color: a New Perspective for Evaluating the Effectiveness of Periodontal Basic Treatment
Objective: This study aims to explore the correlation between gingival color and clinical indicators and inflammatory factors in patients with periodontitis.
- Trial name
- NCT06698718
- Testing
- Periodontal basic treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontitis
Human Dental Pulp Mesenchymal Stem Cells for the Treatment of Chronic Periodontitis Patients
The primary objective:To evaluate the efficacy of different administration protocols of human dental pulp mesenchymal stem cells for the treatment of chronic periodontitis patients.
- Trial name
- NCT05924373
- Testing
- Human Dental Fulp Stem Cells
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
Cardiovascular Diseases, Periodontitis
Effects of Non-surgical Periodontal Therapy on Cardiovascular Risk
This study is to evaluate whether non-surgical periodontal therapy can help to control the cardiovascular risk among patients with moderate/severe periodontitis and at risk of cardiovascular disease.
- Trial name
- NCT05459727
- Testing
- Non-surgical periodontal therapy, Control periodontal treatment
- Where
- 2 sites in China
- Volunteers
- 376 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Periodontitis
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
The study will follow a parallel arm, randomised, double blinded, placebo controlled design. There will be two groups Group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) Group 2 = receiving placebo…
- Trial name
- NCT03790605
- Testing
- 1 % curcumin chip, Scaling and root planing
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Halitosis
Efficacy of Glycine Powder Air-Polishing Combined With Scaling and Root Planing in the Treatment of Periodontitis and Halitosis
The aim of this clinical study was to evaluate the clinical efficacy of using perio flow adjunctively with mechanical instrumentation on periodontal parameters and halitosis.
- Trial name
- NCT03031756
- Testing
- glycine powder air-polishing (Air-Flows)Perio Powder, ultrasonic (Piezon Master 700; EMS, Nyon, Switzerland)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Periodontitis, Type2 Diabetes
Effect of Aspirin Vs Omega 3 Fatty Acid After Scaling and Root Planing in Type II Diabetic Patients With Chronic Periodontitis
The main aim and objective of this study is to compare the effectiveness of low dose aspirin vs omega 3 fatty acids as adjuvants to non-surgical periodontal therapy and also to evaluate the levels of pentraxin 3 and glycosylated…
- Trial name
- EAOFASRPDMCP (NCT03599401)
- Testing
- Scaling and root planing
- Where
- India
- Volunteers
- 42 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis
IL-32 Levels in Patients With Chronic Periodontitis
Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α.
- Trial name
- NCT02632981
- Testing
- nonsurgical periodontal treatment, Gingival crevicular fluid and saliva collection
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The study proposes to assess the effect of multiple applications of antimicrobial Photodynamic Therapy (aPDT) as an adjunct to non-surgical periodontal treatment (nsPT) in smokers without use of antibiotics.
- Trial name
- NCT03039244
- Testing
- Photodynamic therapy, Control Group, Diode Laser
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Amelogenins
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of amelogenins, compared to MINSD alone.
- Trial name
- NCT05315804
- Testing
- MINSD and amelogenins, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontitis
Impact of Periodontal Bacteria on the Effectiveness of Periodontal Therapy
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of periodontitis, the aim of this study was to evaluate, at 6 months…
- Trial name
- NCT05558293
- Testing
- Scaling and root planing
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontitis (Stage 3)
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis
This study aimed to assess the effect of Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent in surgical periodontal treatment on clinical parameters and cytokine levels (IL-6, IL-8, IL-10, IL-17A, TOS, and TAS) in…
- Trial name
- Periodontit (NCT06842511)
- Testing
- open flap debridement and Hyaluronic Acid-Based Gel application, open flap debridement
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Ordu University
Periodontitis, Aggressive, Periodontal Diseases
Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.
The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with…
- Conditions
- Periodontitis, Aggressive, Periodontal Diseases, Periodontitis
- Trial name
- ERISRP (NCT05112471)
- Testing
- Airflow, Perioflow and Erythritol powder and ultrasonic debridement, Ultrasonic debridement and curettes
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Periodontitis
Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation.
- Trial name
- NCT05608564
- Testing
- Piperacillin and Tazobactam in gel form, Amoxicillin and Metronidazole
- Where
- Serbia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Peri-implant Mucositis
Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis
the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators.
- Trial name
- PiM_Inc (NCT05356806)
- Testing
- Supportive periodontal and periimplant care
- Where
- Spain
- Volunteers
- 277 people
- Sponsor
- Universidad Complutense de Madrid
Periodontitis, Dysbiosis
Gut Microbial Changes After Periodontal Treatment
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients.
- Conditions
- Periodontitis, Dysbiosis, Intestinal Disease
- Trial name
- NCT04982302
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- University of Turin, Italy
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Periodontitis, Adult
Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects
The aim: Clinical and Radiographic Evaluation for intra-osseous defects in stage III periodontitis using NIPSA versus M-MIST Steps in short Pre-surgical therapy Before surgical intervention, each patient will be given careful…
- Trial name
- NCT04149834
- Testing
- Group A (Test): Patients will receive NIPSA, Group B (Control): Patients will receive M-MIST
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
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