Clinical trials: Treatment-as-usual
Post-Traumatic Stress Disorder
Virtual Reality (VR) Therapy for Post-Traumatic Stress Disorder (PTSD)
It is proposed that using Virtual Reality as part of therapy will result in improvements in Post Traumatic Stress Disorder for Service Members with PTSD related to service in Iraq and/or Afghanistan.
- Trial name
- NCT00992953
- Testing
- Treatment as Usual, Virtual Reality Exposure with Stimulus Control
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Office of Naval Research (ONR)
Parkinsonism, Experimental, Parkinsonism, Treatment as Usual
BEWARE: Body Awareness Training in the trEatment of Wearing-off Related Anxiety in Patients With paRkinson's Disease
Approximately 60% of the patients with Parkinson's Disease (PD) that receive Levodopa therapy eventually develop response fluctuations in motor symptoms, such as rigidity, freezing and akinesia.
- Trial name
- BEWARE (NCT02054845)
- Testing
- Body awareness therapy, Physical therapy
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Amsterdam UMC, location VUmc
Intellectual Disabilities, Depression
Behavioural Activation and Severe Learning Disabilities
Research shows that people with severe learning disabilities get depressed at least as often as the wider population. Psychological therapies are recommended to treat depression, and some of these have been adapted for those…
- Trial name
- NCT06851741
- Testing
- Behavioural Activation for depression (BeatIt2)
- Volunteers
- 50 people
- Sponsor
- NHS Greater Glasgow and Clyde
Advanced Cancer, Neoplasms
The "Hand-in-Hand Study": Improvement of Quality of Life in Palliative Cancer Patients Through Collaborative Advance Care Planning
This study evaluates the effect of a collaborative advance care planning intervention on the quality of life in palliative oncological patients.
- Conditions
- Advanced Cancer, Neoplasms, End Stage Cancer
- Trial name
- COLAP (NCT03387436)
- Testing
- Study-Intervention
- Where
- 2 sites in Germany
- Volunteers
- 280 people
- Sponsor
- PD. Dr. med. Carola Seifart
Patient Decision Aid, Treatment As Usual
Shared Decision Making on Immunotherapy in Oncology
Patients with advanced melanoma are confronted with a serious treatment decision. The current guideline recommends considering the option of immunotherapy with checkpoint inhibitors.
- Trial name
- PEF-Immun (NCT04240717)
- Testing
- Patient Decision Aid
- Where
- 2 sites in Germany
- Volunteers
- 126 people
- Sponsor
- University Hospital Heidelberg
Psychosis, Intellectual Disability
Study to Compare Clozapine vs Treatment as Usual in People With Intellectual Disability & Treatment-resistant Psychosis
This clinical trial will prove whether a large number of people with intellectual disability and treatment-resistant psychosis could benefit from the use of clozapine.
- Trial name
- CLOZ-AID (NCT04529226)
- Testing
- Clozapine, haloperidol, pimozide, olanzapine, risperidone, amisulpride
- Where
- 20 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
COVID-19 Infection
Clinical Trial to Evaluate the Efficacy and Safety of an Immunomodulatory Therapy for the Treatment of Patients With Moderate to Severe COVID-19 Infection
An Open-label, prospective, randomized, comparative, multiple doses applied in addition to the standard of care treatment of patients with moderate to severe COVID-19 infection
- Trial name
- NCT04374032
- Testing
- metenkefalin + tridecactide, The standard of care
- Where
- 5 sites in Bosnia and Herzegovina
- Volunteers
- 120 people
- Sponsor
- Bosnalijek D.D
Compassion, Treatment as Usual
Cognitively-Based Compassion Training for Breast Cancer Survivors
There is a growing number of evidence of how mindfulness training enhances psychological and physical well-being and coping strategies in patients with oncological illnesses.
- Trial name
- CBCT-BC (NCT03305952)
- Testing
- CBCT, TAU
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- University of Valencia
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy
The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual (TAU) to improve the initiation of guideline-adherent postoperative radiation therapy…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer, Oral Cavity Cancer
- Trial name
- ENDURE (NCT05793151)
- Testing
- ENDURE
- Where
- 4 sites in United States
- Volunteers
- 532 people
- Sponsor
- Medical University of South Carolina
Schizophrenia
A 2-year Study of Patients With Schizophrenia Who Are Treated With Long-acting Injectable Risperidone.
The purpose of this study is to examine treatment practices of adult schizophrenia patients by their own doctors, and to assess patient outcomes when treated with long-acting risperidone injection over a two-year period of…
- Trial name
- NCT00261430
- Testing
- GAIN Acceptance Approach
- Volunteers
- 650 people
- Sponsor
- Janssen, LP
Deficits, Neurologic, Extreme Prematurity
SafeBoosC III Two-year Follow-up
The SafeBoosC-III 2 year follow up study will follow up on all patients randomised in the SafeBoosC-III clinical trial (NCT03770741).
- Conditions
- Deficits, Neurologic, Extreme Prematurity, Brain Damage
- Trial name
- NCT05134116
- Testing
- Treatment as usual + cerebral oximetry monitoring the first 72 hours of life
- Where
- Denmark
- Volunteers
- 1,601 people
- Sponsor
- Gorm Greisen
Osteoarthritis, Knee, Osteoarthritis, Hip
Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention
The purpose of this study is to evaluate how older adults might benefit from sessions that teach behavioral coping skills for increasing physical activity and reducing interference from arthritis pain.
- Trial name
- NCT04490395
- Testing
- Engage PA, Treatment as Usual plus (TAU+)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Somatic Symptom and Related Disorders, Intensive Short Term Dynamic Psychotherapy
Halifax Somatic Symptoms Disorder Trial
The purpose of this pilot study is to compare the effectiveness of Intensive Short-Term Dynamic Psychotherapy (ISTDP) plus Medical Care As Usual (MCAU) compared to MCAU for Somatic Symptom and Related Disorders (SSRD).
- Trial name
- NCT02076867
- Testing
- Intensive Short-Term Dynamic Psychotherapy, Medical Care As Usual (MCAU)
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Nova Scotia Health Authority
Substance Use Disorders, Alcohol Use Disorder
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
Substance Use Disorders continue to increase across the United States with significant adverse effects resulting in more than $700 billion annually (NIDA, 2017) with high co-occurring rates of IPV.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Stimulant-Related Disorder
- Trial name
- NCT05943171
- Testing
- Cognitive Behavioral Therapy, Standard CBT
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Psychological Distress, Cancer Recurrence
COMpassion FOcused Therapy and Breathing Pattern REtraining After Cancer Recurrence
The purpose of this study is to investigate how effective a particular psychological intervention is at reducing psychological distress for people who were diagnosed with cancer 'recurrence' since the beginning of the COVID…
- Trial name
- COMFORT (NCT05518591)
- Testing
- Compassion Focused Therapy (CFT) combined with Breathing Pattern Retraining (BPR)
- Where
- Ireland
- Volunteers
- 160 people
- Sponsor
- University College Dublin
Psychological Intervention, Treatment as Usual
Does Five Session CAT Consultancy Lead to Improved Outcomes?
Five session CAT (Cognitive Analytic Therapy) consultancy was developed for patients whom services 'struggle to help', such as those with diagnoses of personality disorder.
- Trial name
- NCT03998072
- Testing
- Five session cognitive analytic therapy (CAT) consultancy
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Amrit Sinha
Osteoarthritis
Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis
Comparison of treatment cost of knee osteoarthritis (OA) in patients treated with Synvisc® versus usual treatments as well as evaluation of safety and effectiveness of these treatments.
- Trial name
- NCT02197026
- Testing
- Hylan G-F 20, Standard treatment, Physiotherapy
- Volunteers
- 518 people
- Sponsor
- Boehringer Ingelheim
Depression - Major Depressive Disorder, Anxiety
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
This parallel three-arm, single-blind (assessor-blinded), randomized controlled trial (RCT) aims to compare the effects of ACT, CBT, and treatment-as-usual (TAU) on the severity of depressive symptoms (primary outcome), the…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Marital Conflict
- Trial name
- NCT07808021
- Testing
- Acceptance and Commitment Therapy, Cognitive Behavioral Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Hand Eczema
A 24-week Single-blind Trial of Prevention of Hand Eczema in Cleaners
This study aims to investigate the effectiveness of picture-based prevention education among professional hospital cleaners in relation to hand eczema.
- Trial name
- HEIC (NCT05763914)
- Testing
- Change in the incidence of hand eczema, Change in severity of hand eczema, Change in the number of self-reported days with absence from work due to having hand eczema
- Where
- Denmark
- Volunteers
- 234 people
- Sponsor
- Zealand University Hospital
Severe Mental Illness, Substance Use Disorder (SUD)
A Study to Investigate Health Related Quality of Life With a Pharmacist Intervention Compared to Treatment as Usual in Participants With Severe Mental Illness and Substance Use Disorder Receiving Treatment From FACT Teams.
The study aims to evaluate the impact of integrating a clinical pharmacist into Flexible Assertive Community (FACT) teams on health-related quality of life and pharmacotherapy for individuals with severe mental illness and…
- Trial name
- pharmaFACT (NCT07597863)
- Testing
- Clinical Pharmacist Intervention
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- Sykehuset Innlandet HF