Clinical trials: Treatment-resistant Bipolar Depression
Bipolar Depression, Treatment Resistant Depression
Intensive TMS for Bipolar Depression
The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham.
- Trial name
- NCT05228457
- Testing
- Intensive intermittent theta-burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Pennsylvania
Metabolic Syndrome, Bipolar Depression
Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance
The study is an open-label 8-week adjunctive trial of pioglitazone for the acute relief of bipolar depression comorbid with metabolic syndrome/insulin resistance.
- Conditions
- Metabolic Syndrome, Bipolar Depression, Insulin Resistance
- Trial name
- NCT00835120
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Major Depressive Disorder, MDD
A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD)
The study will only detect hypomanic symptoms in treatment resistant MDD patients by mean of HCL-32 administration. Further re-evaluation of MDD diagnosis is not a direct aim of the study.
- Trial name
- Improve (NCT01344733)
- Where
- 29 sites in Italy
- Volunteers
- 660 people
- Sponsor
- AstraZeneca
Bipolar Disorder, Insulin Resistance
Pioglitazone for the Treatment of Bipolar Depression
The primary objective is to test the hypothesis that adjunctive pioglitazone is more effective than placebo for the relief of acute depressive symptoms resulting from bipolar disorder.
- Trial name
- NCT01717040
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University Hospitals Cleveland Medical Center
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Treatment-Resistant
DBS for Treatment Resistant Depression
The purpose of this study is to examine the effects of sub-callosal cingulate (SCC) deep brain stimulation (DBS) in patients with treatment resistant depression (TRD).
- Trial name
- CRIO-DBS (NCT01983904)
- Testing
- deep brain stimulation with short & long pulse width
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant
Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)
In this pilot study, we propose to test whether high frequency stimulation of the subcallosal cingulate (SCC) is a safe and efficacious antidepressant treatment in five TRD patients, to compare the effects of left-sided vs.
- Conditions
- Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
- Trial name
- NCT01898429
- Testing
- SCC DBS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Paul Holtzheimer
Bipolar Disorder
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
The purpose of this study is to compare the efficacy and side effects magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD).
- Trial name
- NCT04080778
- Testing
- magnetic seizure therapy (MST), electroconvulsive therapy (ECT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joao L. DeQuevedo
Schizophrenia, Schizophrenia and Related Disorders
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive…
- Conditions
- Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders
- Trial name
- NCT06748950
- Testing
- LCHF Ketogenic Diet, Diet-as-Usual (DAU)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Depression, Bipolar Disorder
Insulin Resistance in Patients With Mood Disorder
Insulin resistance is known to be associated with mood disorders and cognitive difficulties. The purpose of this study is to treat depressed patients with rosiglitazone (also known as [AKA] Avandia), therefore improving glucose…
- Conditions
- Depression, Bipolar Disorder, Insulin Resistance
- Trial name
- NCT00242619
- Testing
- rosiglitazone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Depression, Depressive Disorder
Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive Therapy
To evaluate the equivalent efficacy of ultrabrief pulsewidth right unilateral electroconvulsive therapy versus bitemporal brief pulse electroconvulsive therapy in the treatment of depression and to evaluate the cognitive effects…
- Conditions
- Depression, Depressive Disorder, Treatment Resistant Depressive Disorder, Bipolar Disorder
- Trial name
- NCT02238730
- Testing
- Ultrabrief Right Unilateral, Brief Pulse Bitemporal
- Sponsor
- Kaiser Permanente
Treatment Resistant Depression, Bipolar Depression
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders
This study aims to openly test the long-term safety, tolerability and effectiveness of repeated administration of IV, nasal spray and oral ketamine for treatment-resistant mood disorders.
- Conditions
- Treatment Resistant Depression, Bipolar Depression, Ketamine, Major Depressive Disorder
- Trial name
- GDKet (NCT04226963)
- Testing
- Ketamine
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Bipolar Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment Resistant Bipolar Depression
We hope to learn whether this stimulation of neurons in the front part of the brain may relieve depression.
- Trial name
- NCT00186485
- Testing
- MagStim
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
The goal of this observational study is to evaluate whether vagus nerve stimulation (VNS) intervention can reduce depressive symptoms and suicidality in adults with higher-grade treatment-resistant depression (HG-TRD)-individuals…
- Conditions
- Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder, Bipolar Depression
- Trial name
- VNS TRD HG-TRD (NCT07097025)
- Testing
- vagus nerve stimulation
- Where
- 2 sites in Israel
- Volunteers
- 19 people
- Sponsor
- Dr.Yoav Domany
Bipolar Depression
Deep Brain Stimulation of Treatment-Resistant Bipolar Depression
This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only.
- Trial name
- DBS in TRBD (NCT06599099)
- Testing
- Medtronic Percept RC System, One Month Blinded Discontinuation Period
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wayne Goodman MD
Depression
Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses
This is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different amounts of electrical charge for the treatment…
- Trial name
- NCT00305565
- Testing
- VNS Therapy
- Where
- 26 sites in United States
- Volunteers
- 331 people
- Sponsor
- Cyberonics, Inc.
Bipolar Disorder, Bipolar Depression
Ketamine for Treatment-Resistant Bipolar Disorder
Growing evidence has supported rapid and robust antidepressant effects with subanesthetic doses of intravenous (IV) ketamine for treatment resistant depression (TRD).
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- KET-BD (NCT05004896)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 71 people
- Sponsor
- Joshua Rosenblat
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Treatment- Resistant Bipolar Disorder, Bipolar Disorder
Nitrous TRD Bipolar Depression
Investigators will study approximately 64 patients with Treatment-Resistant Bipolar Depressive Disorder, defined as a failure of at least 1 antidepressants in the current depressive episode and 2 lifetime medication failures.
- Conditions
- Treatment- Resistant Bipolar Disorder, Bipolar Disorder, Bipolar Depressive Disorder
- Trial name
- NCT02757521
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder, Recurrent Depressive Disorder
Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression
Major depressive disorders are real public health issues in terms of diagnosis and treatment. Some forms of depression are chronic and resistant to treatment (TRD). In these forms suicide risk is important.
- Conditions
- Major Depressive Disorder, Recurrent Depressive Disorder, Bipolar Disorder
- Trial name
- STHYM (NCT01973478)
- Testing
- DBS
- Where
- 5 sites in France
- Volunteers
- 9 people
- Sponsor
- Rennes University Hospital