Clinical trials: Tremor
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Essential Tremor
Electroclinical Correlates in Essential Tremor
Essential tremor (ET) is a neurological disorder that affects nearly 0.9% of the world's population. High-frequency Deep Brain Stimulation (DBS) of the ventral-intermediate nuclei of the thalamus (VIM) has been proven as an…
- Trial name
- ECOLOVIM (NCT05671848)
- Testing
- Recordings of thalamic activity
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Essential Tremor
Image-Guided DBS Programming
The objective of this study is to compare the effects of image-guided programming algorithm using various image segmentations vs standard clinical programming on reduction of tremor and patient satisfaction.
- Trial name
- NCT07433699
- Testing
- programming a, programming b
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Essential Tremor, Essential Tremor (ET)
Circadian Adaptive DBS in Essential Tremor
Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the…
- Conditions
- Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
- Trial name
- NCT06635811
- Testing
- Circadian Adaptive DBS, Conventional DBS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease, Essential Tremor
Sensory-specific Peripheral Stimulation for Tremor Management
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons.
- Trial name
- NCT04501133
- Testing
- Peripheral electrical stimulation, Single pulse TMS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Essential Tremor, Healthy Individuals
Impact of Sensory Electrical Stimulation on Sensation and Tremor
The purpose of this study is to understand the acute, short-term and long-term impact of transcutaneous and/or percutaneous electrical stimulation with afferent-specific electrical stimulation (asES) on proprioception and fine…
- Trial name
- NCT06428526
- Testing
- Continuous stimulation strategy, Closed-loop stimulation strategy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Tremor, Essential Tremor
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System.
- Trial name
- rT DBS (NCT07049003)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Cleveland Clinic
Essential Tremor
Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor
The goal of this clinical study is to compare Felix NeuroAI Wristband and sham device in patients with essential tremor. The main question it aims to answer is: Is Felix a safe and efficacious treatment for patients with…
- Trial name
- TRANQUIL (NCT06235190)
- Testing
- Felix NeuroAI Wristband
- Where
- 12 sites in United States, China
- Volunteers
- 125 people
- Sponsor
- Fasikl Inc.
Essential Tremor, Parkinson Disease
Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson's Tremor
A prospective, open-label, multi-center pilot study designed to evaluate the safety and effectiveness of the Felix system in the relief of upper limb tremors in adults with essential tremor and Parkinson's disease.
- Trial name
- NCT05842434
- Testing
- Felix NeuroAI Wristband
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Fasikl Inc.
Parkinson's Disease, Movement Disorders
Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
The goal of this clinical trial is to explore the effects of cerebellar nuclei TIS stimulation on improving tremor and gait disorders in PD patients.
- Trial name
- NCT07384442
- Testing
- Real Temporal Interference Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- YangPan
Loss of Consciousness, Parkinson Disease
Brain Networks and Consciousness
General anesthesia (GA) is a medically induced state of unresponsiveness and unconsciousness, which millions of people experience every year.
- Conditions
- Loss of Consciousness, Parkinson Disease, Essential Tremor, Anesthesia
- Trial name
- NCT04502550
- Testing
- Propofol
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Texas Southwestern Medical Center
Essential Tremor
Optimization of VIM Targeting in Essential Tremor Surgery
Deep brain stimulation (DBS) for essential tremor is based on the intermedius ventralis nucleus of the thalamus (VIM) stimulation. This structure is however very difficult to target, as it remains invisible on imaging.
- Trial name
- Opti-VIM (NCT03760406)
- Testing
- Opti-VIM targeting in DBS surgery
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Essential Tremor
Decision-making and Emotion Recognition in Essential Tremor
The present study aims at investigating cognitive functions requiring orbitofrontal control, namely decision-making and facial emotion recognition.
- Trial name
- EMOTREM (NCT01223144)
- Testing
- Iowa Gambling Task and Ekman facial recognition test
- Where
- France
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Essential Tremor of the Upper Limb
A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm
The purpose of this study is to determine whether a single treatment with NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the motor-dominant arm (Unilateral Period).
- Trial name
- NCT04766723
- Testing
- NT 201
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 78 people
- Sponsor
- Merz Pharmaceuticals GmbH
Kidney Transplant Recipients, Old Age
Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients
The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extended-release tacrolimus…
- Trial name
- Neuro-KTR (NCT06751992)
- Testing
- Conversion to extended-release tacrolimus, Maintenance of immediate-release tacrolimus
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Essential Tremor, Parkinsonian Disorders
Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL)
Radiosurgical thalamotomy on GammaKnife has been shown to be effective in the management of tremors. However, several teams describe a significant risk of severe neurological complications.
- Trial name
- FRACTHAL (NCT04727658)
- Testing
- Radiosurgical thalamotomy on GammaKnife
- Where
- Monaco
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Essential Tremor, Dystonia
The Effect of Alcohol on Common Tremor Syndromes
The aim of this interventional study is to compare the response to alcohol in patients with essential tremor (ET), essential tremor plus (ETplus), dystonic tremor (DT), tremor associated with dystonia (TaD) and tremor in…
- Conditions
- Essential Tremor, Dystonia, Parkinson Disease
- Trial name
- NCT06403280
- Testing
- Alcoholic drink
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Graz
Essential Tremor
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor
This open-label pilot study will evaluate the safety, tolerability, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound pulsation (LIFUP) targeting the ventral intermediate nucleus (Vim) of the…
- Trial name
- NCT07599592
- Testing
- Low Intensity Focused Ultrasound (LIFU)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles