Clinical trials: Tremors
Multiple Sclerosis
MRI Guided Focused Ultrasound for Tremor in Multiple Sclerosis
This project goal is to explore the option of (MRgFUS) as a treatment for tremor in MS patients with disabling refractory tremor.
- Trial name
- NCT02614989
- Testing
- MRI guided focused ultrasound thalamotomy
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Essential Tremor
Nonlinear Absorber in Essential Tremor Treatment
The goal of this study is to develop a non linear absorber for patients with essential tremor (ET). It 's an extern passive medical device which should improve patients tremor.
- Trial name
- TREM-AB (NCT06397391)
- Testing
- TREM-AB
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Movement Disorders, Essential Tremor
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders
The proposed study is to evaluate the effectiveness of ExAblate Transcranial MRgFUS as a tool for creating a unilateral lesion in the Vim thalamus or the globus pallidus (GPi) in patients with treatment-refractory symptoms of…
- Conditions
- Movement Disorders, Essential Tremor, Holmes Tremor, Parkinson's Disease
- Trial name
- NCT02252380
- Testing
- Transcranial ExAblate System
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- InSightec
Parkinson Disease
Transcutaneous Afferent Patterned Stimulation (TAPS) for Reduction of Parkinson's Disease (PD) Related Action Tremor
Demonstrate safety and efficacy of TAPS delivered by a Cala device as a treatment for action tremor in subjects with Parkinson's disease hand tremor
- Trial name
- NCT05012579
- Testing
- Cala Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cala Health, Inc.
Essential Tremor
A Study of Wearable Device in Essential Tremor Patients
The purpose of this research is to observe the daily loss of benefit from DBS therapy by performing a standardized set of tasks throughout the day while wearing an Apple Watch to collect movement and other physiological data.
- Trial name
- NCT05976074
- Testing
- Apple Watch, BrainRISE app
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Orthostatic Tremor
Modulating Cerebellar Activity With Low-intensity Focused Ultrasound Stimulation for Primary Orthostatic Tremor
Primary orthostatic tremor (POT) is a rare movement disorder that is manifested through high frequency tremor of weight bearing limbs. This is often accompanied by a debilitating sensation of falling.
- Trial name
- LIFUS-POT (NCT05547620)
- Testing
- LIFUS Online Real, LIFUS Offline
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Essential Tremor
Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients
The aim of the study is to investigate the Effect of Repetitive Transcranial Magnetic Stimulation on Essential Tremors.
- Trial name
- NCT05157321
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Parkinson Disease
PSA Versus STN DBS for TD-PD
The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of tremor-dominant Parkinson's disease (PD) in a…
- Trial name
- PSA-STN (NCT05382858)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Ruijin Hospital
Essential Voice Tremor, Vocal Tremor
Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Essential voice tremor is a neurological condition that produces a regular, shaking quality in the voice. One form of drug treatment that produces some improvement in tremor of the hands is octanoic acid, which is a food additive…
- Conditions
- Essential Voice Tremor, Vocal Tremor, Voice Tremor, Essential Tremor of Voice
- Trial name
- NCT01864525
- Testing
- Octanoic acid, Inactive capsule
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Syracuse University
Overweight
Shake It Up: Lipidomics of Lipoproteins and Diet
The purpose of this research is to understand how dietary fat is related to cardiovascular disease (CVD). This study tests the effect of different dietary fats on the level of fat in the blood and the particles that transport fat…
- Trial name
- NCT04120220
- Testing
- Heavy Cream, Soybean Oil
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Tics, Tic Disorders
Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder
The goal of this clinical study is to learn more about the timing of tics (sudden, fast movements and sounds that people do and make without meaning to) in people who have multiple tics that have been going on for more than one…
- Conditions
- Tics, Tic Disorders, Vocal Tic, Motor Tic
- Trial name
- PTD (NCT06385535)
- Testing
- Habit Reversal Training (HRT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Essential Tremor
Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor
Recently, there has been increasing interest in performing DBS under general anesthesia, where the stimulated targets are located anatomically (i.e.
- Trial name
- NCT02418858
- Testing
- Deep Brain Stimulation surgery
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Deep Brain Stimulation, Parkinson Disease
The BRAINMAP-DBS Study: BRain Network AnalysIs usiNg 7-Tesla MRI and MAgnetoencephalograPhy for Deep Brain Stimulation
Rationale: Deep brain stimulation (DBS) is an effective treatment for essential tremor and Parkinson's disease. The effect of DBS relies on the modulation of dysfunctional motor brain networks and on average 50% motor improvement…
- Conditions
- Deep Brain Stimulation, Parkinson Disease, Essential Tremor, Magnetoencephalography (MEG)
- Trial name
- BRAINMAP-DBS (NCT06932692)
- Testing
- magnetoencephalography
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
PARKINSON DISEASE (Disorder), Tremor
Effect of Kinesiotaping on Tremor in People With Parkinson's Disease
The goal of this clinical trial is to learn whether adding kinesiotaping to a strengthening and stretching home-exercise program can reduce hand tremor and improve hand function in people with Parkinson's disease.
- Conditions
- PARKINSON DISEASE (Disorder), Tremor, Tremor Associated With Tremor Dominant Parkinson's Disease
- Trial name
- NCT07555847
- Testing
- Therapeutic Kinesiotaping, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Neuroleptic-Induced Tremor
Gabapentin for the Treatment of Neuroleptic-Induced Tremor
We will attempt to establish whether gabapentin as compared with placebo will reduce the severity of tremors caused by the use of antipsychotic medications.
- Trial name
- NCT00533455
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Upper Limb Essential Tremor
Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Essential Tremor
Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating.
- Trial name
- NCT07673107
- Testing
- AGN-151607-DP
- Where
- 21 sites in United States, Canada
- Volunteers
- 94 people
- Sponsor
- AbbVie
Parkinson Disease, Essential Tremor
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor
This study investigates the long-term safety and tolerability of home peroneal eTNM® therapy using the URIS I™ device in subjects with Parkinson's disease (PD) or Essential Tremor (ET).
- Trial name
- NCT06570421
- Testing
- Peroneal electrical transcutaneous neuromodulation (peroneal eTNM®)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Stimvia s.r.o.
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Essential Tremor
Pregabalin (Lyrica) for the Treatment of Essential Tremor
This will be a multi-site, prospective, double-blind, randomized, placebo-controlled, crossover trial conducted over 6 months to assess the effectiveness and safety of PGB to treat symptoms of ET.
- Trial name
- NCT00584376
- Testing
- Pregabalin
- Where
- 8 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of South Florida
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)