Clinical trials: Treponema Pallidum
Syphilis Infection, Syphilis
Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sites
This study is a prospective cross-sectional study in which surgically non-invasive sample- taking is done only for the purpose of the study.
- Trial name
- NCT06365606
- Testing
- iStatis Syphilis Ab Test
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
Gonorrhea, Chlamydia
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
The purpose of this study is to understand if taking an antibiotic called doxycycline by mouth as soon as possible after sexual contact without a condom can reduce the risk of sexually transmitted infections (STIs), including…
- Conditions
- Gonorrhea, Chlamydia, Syphilis
- Trial name
- NCT03980223
- Testing
- Doxycycline Hyclate Delayed-Release 200 mg
- Where
- 3 sites in United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Syphilis, HIV
Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia
Global and regional initiatives have been launched for the dual elimination of mother-to-child transmission (MTCT) of HIV and syphilis.
- Trial name
- NCT02454816
- Testing
- Single HIV RDT and single syphilis RDT, Dual HIV/syphilis RDT
- Where
- Colombia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Neurosyphilis, Biomarkers
Cohort-Based Study of Diagnostic Biomarkers for Neurosyphilis
The goal of this observational study is to identify diagnostic biomarkers for neurosyphilis in patients with the condition. The main questions it aims to answer are: What plasma biomarkers are associated with neurosyphilis? What…
- Conditions
- Neurosyphilis, Biomarkers, Proteomics
- Trial name
- NCT06680011
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Hiv, Syphilis
The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)
The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple…
- Conditions
- Hiv, Syphilis, HBV
- Trial name
- TRI-MOM (NCT05951751)
- Testing
- TRI-MOM intervention
- Where
- 2 sites in Burkina Faso, The Gambia
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
HIV, Syphilis
Implementation of an Efficacious Intervention for High Risk Women in Mexico
This project seeks to determine the personal and organizational conditions that are most conducive to the widespread adoption by community-based organizations (CBOs) of effective programs for reducing the spread of HIV and other…
- Conditions
- HIV, Syphilis, Gonorrhea, Chlamydia
- Trial name
- NCT01465607
- Testing
- Mujer Segura, CENSIDA counseling program
- Where
- 4 sites in Mexico
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Syphilis
Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis
The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test (POCT) to diagnose infectious syphilis in participants attending the…
- Trial name
- NCT06927843
- Testing
- point of care test
- Where
- Canada
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Syphilis, HIV Infections
Syphilis and HIV Point of Care Testing (POCT) in Saskatchewan
The goal of this clinical trial is to learn about Syphilis and HIV point of care testing among inner city, remote, rural and hard to reach populations in Saskatchewan. The main question[s] it aims to answer are: 1.
- Trial name
- SHIVER (NCT05863117)
- Testing
- Reveal Rapid TP (from MedMira)
- Where
- 2 sites in Canada
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- Wellness Wheel Medical Clinic
Syphilis
Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST)
Syphilis infection is a major global health problem, leading to substantial morbidity among key populations in low- and middle-income countries (LMICs).
- Trial name
- NCT04480749
- Testing
- Access to Facility based Syphilis Testing, Syphilis Self-Test
- Where
- Zimbabwe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Bacterial Infections, Acute Viral Infections
300 Antibody Diagnostic Test Kit
For the development of a Point of Care IVD test kit for acute phase disease detection against a variety of bacterial and viral infections.
- Trial name
- Antibody 300 (NCT01646411)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Plasma Source
HIV Infections
Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison
It is difficult to detect the intestinal protozoal infections among the HIV-infected persons or travelers diarrhea by using the traditional microscopy or staining methods.
- Trial name
- NCT00739258
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Multiplex Testing of HIV, HBV, HCV and Syphilis, HIV
Clinical Performance Evaluation of MagIA IVD-MD Multiplex Testing (HIV/HBV/HCV/Syphilis)
Performance study to evaluate the clinical performance of the In-Vitro Diagnostics Medical Device MagIA H3S (a Multiplex Point-of-Care test for the combined detection of Human Immunodeficiency Virus (HIV), Hepatitis B and C and…
- Conditions
- Multiplex Testing of HIV, HBV, HCV and Syphilis, HIV, HBV, HCV
- Trial name
- MAGICS IBCS (NCT07170748)
- Where
- 2 sites in Côte d’Ivoire, Kenya
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- MagIA Diagnostics
HIV Infections, Sexually Transmitted Diseases
Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
This is a prospective cohort study evaluating acceptability, feasibility, and effectiveness of integrating HIV pre-exposure prophylaxis (PrEP) into a sexually transmitted infection (STI) clinic alongside assisted partner…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Blood-Borne Infections, Communicable Disease
- Trial name
- NCT05307991
- Testing
- PrEP, STI testing, Assisted partner notification
- Where
- Malawi
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Syphilis
Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador
The purpose of this observational study is to estimate the number of new HIV infections and the number and variability of antiretroviral-resistant HIV strains among men who have sex with men (MSM).
- Conditions
- HIV Infections, Syphilis, Sexually Transmitted Diseases
- Trial name
- NCT00279331
- Where
- 6 sites in Ecuador, Peru
- Volunteers
- 2,608 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers, Syphilis Serologic Assay Development
Blood Donation Study for ALPCO Syphilis-T and Syphilis-NT Assay Development
This prospective, single-center study will collect blood from approximately 50 adult volunteers aged 22 years or older. Participants will provide informed consent, complete an eligibility review, and undergo one blood draw of…
- Conditions
- Healthy Volunteers, Syphilis Serologic Assay Development, Blood Specimen Collection, Diagnostic Assay Development
- Trial name
- NCT07830550
- Testing
- ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Syphilis
Azithromycin/Bicillin Syphilis
The purpose of this study is to determine if azithromycin, a drug approved for treatment of other infections, is as effective for syphilis (a sexually transmitted disease) as the standard treatment.
- Trial name
- NCT00031499
- Testing
- Azithromycin, Benzathine Penicillin, Doxycycline
- Where
- 10 sites in United States, Madagascar
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Syphilis, Gonorrhea
Lay Health Advisors for Sexually Transmitted Disease Prevention
Non-professional community leaders may be at a great advantage in reaching otherwise hard to reach populations for the purpose of advising on sexually transmitted disease (STD) prevention (lay health advisors), health care…
- Conditions
- Syphilis, Gonorrhea, Chlamydia Infections, HIV Infections
- Trial name
- NCT00207506
- Testing
- HoMBReS: A lay health advisor approach to STD prevention
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Syphilis
Multi-site Study of Rapid Diagnostic Syphilis Assays
The performance of an investigational immunochromatographic strip (ICS) test for the diagnosis of syphilis is compared with the Abbott Laboratories Determine ICS test.
- Trial name
- NCT00300534
- Testing
- Abbott Laboratories Determine test for syphilis, Investigational syphilis immunochromatographic strip test
- Where
- 5 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention