Clinical trials: Treponema Pallidum Infection
Acute Bacterial Infections, Acute Viral Infections
300 Antibody Diagnostic Test Kit
For the development of a Point of Care IVD test kit for acute phase disease detection against a variety of bacterial and viral infections.
- Trial name
- Antibody 300 (NCT01646411)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Plasma Source
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, Syphilis Infection
Multiplo Near Patient Non-HCP Study
To help reach the undiagnosed living with HIV and/or syphilis in Canada, point-of-care (POC) tests for HIV and Syphilis may have substantial utility for increased identification of infected individuals through their relative ease…
- Trial name
- NCT06463314
- Testing
- Multiplo TP/HIV Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Syphilis
Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)
According to European and US Centers for Disease Control and Prevention (CDC) guidelines, the recommended treatment for uncomplicated early syphilis in adults (i.e.
- Trial name
- SY-DOXY (NCT04838717)
- Testing
- BPG, Doxycycline
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV, Syphilis
Texting Intervention to Sustain HIV Prevention in Women in High-drug-use Contexts
The purpose of this study is to determine whether a program of regular, theory-based text messages that encourages the message recipient to continue practicing safer sex (i.e., using condoms with sex partners) is effective in…
- Conditions
- HIV, Syphilis, Gonorrhea, Chlamydia
- Trial name
- NCT02447484
- Testing
- Mujer Segura Siempre, General Health Message Texts
- Where
- Mexico
- Volunteers
- 600 people
- Sponsor
- University of California, San Diego
Sexually Transmitted Diseases, Syphilis
Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro
The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil…
- Conditions
- Sexually Transmitted Diseases, Syphilis, Gonorrhea, Chlamydia Infections
- Trial name
- NCT07500415
- Testing
- Doxycycline
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
HIV Infections, Sexually Transmitted Diseases, Viral
mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention
Men who have sex with men (MSM), especially young men who have sex with men (YMSM), and transgender women (TGW) have some of the highest rates of HIV and syphilis diagnoses in the United States.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Viral, Syphilis
- Trial name
- NCT06059443
- Testing
- mLab App Plus
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hiv, Syphilis
Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody Test
This study aims to validate the percent agreement of the INSTI Multiplex Human Immunodeficiency (HIV) 1/2 syphilis antibody (Ab) test (INSTI POCT) when used as a self-test by patients compared to conventional serologic testing.
- Trial name
- NCT06953024
- Testing
- INSTI HIV/syphilis Point of Care Self-Test Administration
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Syphilis
Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Department
The purpose of this study is to offer routine lab-based and rapid point of care (POC) syphilis diagnostic testing in the emergency department (ED) and obstetrical (OB) triage , thereby increasing screening and treatment…
- Trial name
- NCT06645106
- Testing
- Rapid Point of Care (POC) Syphilis testing
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections, Sexually Transmitted Diseases
Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
This randomized controlled trial conducted in Rakai District, Uganda, has enrolled 997 HIV positive men and 500 men who declined to learn HIV results (regardless of HIV status).
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Papillomavirus Infections, Genital Herpes
- Trial name
- NCT00124878
- Testing
- Male circumcision
- Where
- Uganda
- Volunteers
- 5,200 people, healthy volunteers welcome
- Sponsor
- Wawer, Maria J., M.D.
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
HIV Infections, Hepatitis C
Multicenter Performance Study of QuadQuik Invitro Diagnostic Device
To Demonstrate Clinical Performance of the TriQuik Invitro Diagnostic Device
- Conditions
- HIV Infections, Hepatitis C, Hepatitis B, Syphilis Infection
- Trial name
- NCT05692505
- Testing
- QuadQuik
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genlantis Diagnostics
Human Papillomavirus Infection, Human Immunodeficiency Virus Infection
HPV Infection, Sexually Transmitted Infections and Anal Dysplasia in the Transgender Population
The goal of this observational study is to estimate the prevalence of HPV infections anal and ENT level and according to HIV status in transgender (TG) population.
- Conditions
- Human Papillomavirus Infection, Human Immunodeficiency Virus Infection, Sexually Transmitted Diseases
- Trial name
- PrevHPV-TG (NCT05981807)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, Herpesvirus 2, Human
Male Circumcision for HIV Prevention in Rakai, Uganda
Circumcision in HIV unifected men may reduce the likelihood of becoming infected with HIV, reduce sexually transmitted infections (STIs) in men, not engender increases in sexual risk behaviors, and be acceptable to men as a…
- Conditions
- HIV Infections, Herpesvirus 2, Human, Syphilis, Genital Diseases, Male
- Trial name
- NCT00425984
- Testing
- Adult male circumcision
- Where
- Uganda
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Hepatitis C
A Methadone Maintenance Treatment Outcome Study in Three Provinces in China
The primary goal of this PHE is to determine the effectiveness of a tailored education program for MMT service providers. It was to be evaluated through methadone dose levels prescribed to new patients after training completion.
- Conditions
- HIV, Hepatitis C, Syphilis, Herpes Simplex Type II
- Trial name
- NCT01315054
- Testing
- MMT provider dosage training, targeted counseling, national guidelines
- Where
- China
- Volunteers
- 4,258 people
- Sponsor
- Centers for Disease Control and Prevention
Syphilis Infection, Gonorrhea
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last…
- Conditions
- Syphilis Infection, Gonorrhea, Chlamydia
- Trial name
- ThaiDoxyPEP (NCT07397403)
- Testing
- Doxycycline (200mg/day)
- Where
- Thailand
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bangrak STIs Center
Syphilis
Syphilis Video Tool to Promote Knowledge and Testing in the ED
The objective of this study is to determine whether the "Syphilis and Men" educational video can be a useful tool to increase syphilis knowledge and testing among English and Spanish-speaking urgent care and emergency department…
- Trial name
- NCT00552539
- Testing
- 'educational video'
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Jacobi Medical Center
Syphilis Infection, Diagnoses Disease
Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care in Burkina Faso
This study used a pre post intervention mixed methods quasi-experimental design with a group of health facilities offering antenatal care (ANC) services (primary health centers in rural area) as the sampling units.
- Trial name
- NCT03156751
- Testing
- Feasibility of introducing onsite test for syphilis in the package of antenatal care at rural primary health care in Burkina Faso
- Volunteers
- 1,205 people
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Syphilis
Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin
A continuing challenge to determining the response to treatment of early syphilis (primary, secondary, early latent syphilis) is exemplified by the substantial proportion of patients who fail to achieve serological cure and…
- Trial name
- NCT02884115
- Testing
- benzathine penicillin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Syphilis
The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings
The investigators compare the treatment results and clicical presentations of different Molecular subtyping of Treponema pallidum
- Trial name
- NCT02871505
- Testing
- Benzathine Penicillin G
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital