Clinical trials: Trimethylamine N-oxide
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
End Stage Renal Disease, Haemodialysis
Combination of Medium Cut-off Dialyzer Membrane and Diet Modification to Alleviate Residual Uremic Syndrome of Dialysis Patients
The study will compare achieved levels of protein-bound uremic toxins with dialysis using a medium cut-off membrane compared to the treatment by online haemodiafiltration with a high-flux dialysis membrane.
- Conditions
- End Stage Renal Disease, Haemodialysis, Diet, Healthy
- Trial name
- NCT04247867
- Testing
- medium cut-off (MCO) dialysis membrane, Dietary fiber mixture (Plantago Psyllium and Inulin), Sodium propionate
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Inflammatory Marker, Gut Microbiome
The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink
Through empirical research evaluating the effects of "JING SI HERBAL TEA LIQUID PACKETS" and "JING SI HERBAL TANG HENG POWDER DRINK" as adjunctive treatments for various cardiovascular diseases, we aim to provide sufficient…
- Conditions
- Inflammatory Marker, Gut Microbiome, Trimethylamine N-oxide, HbA1c
- Trial name
- NCT06522412
- Testing
- JING SI HERBAL TEA LIQUID PACKETS, JING SI HERBAL TANG HENG POWDER DRINK
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Buddhist Tzu Chi General Hospital
STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods.
- Trial name
- TAMIR (NCT05406297)
- Testing
- pressure-temperature sensor guidewire-based measurement
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- Lithuanian University of Health Sciences
Periodontitis, Inflammation
Evaluation of Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
Salivary and serum levels of TMAO and TNF-α can distinguish between individuals with periodontitis and periodontally healthy individuals.
- Conditions
- Periodontitis, Inflammation, Trimethylamine N-oxide (TMAO), TNF-alfa
- Trial name
- TMAO (NCT06906510)
- Testing
- Salivary and Serum TMAO Mesurement, Salivary and Serum TNF-α Mesurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Diabetes Mellitus, Type 2, Heart Diseases
The Effects of an 8-week Vegan Diet on TMAO Levels and Post-challenge Glucose Levels in Individuals With Dysglycaemia
The amount of people with diabetes mellitus has now reached over 4 million in the United Kingdom. Type 2 diabetes accounts for the majority of all cases of diabetes and increases the risk of many other diseases such as heart…
- Trial name
- PYH (NCT03315988)
- Testing
- Adoption of a vegan diet
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Leicester
Periodontitis, Smoking
Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
Salivary and serum levels of TMAO and TNF-A can distinguish between individuals with periodontitis and periodontally healthy persons, including smoking and nonsmoking patients.
- Conditions
- Periodontitis, Smoking, Inflammatory Response
- Trial name
- NCT06580431
- Testing
- Saliva and serum sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Dietary Modification, Cardiovascular Diseases
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota.
- Trial name
- NCT03781011
- Testing
- Vegetarian diet intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Metabolism
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.
- Trial name
- NCT04255368
- Testing
- Water-soluble choline, Fat-soluble choline, No choline control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Utah State University