Clinical trials: Trimethylamine-N-oxide
Cardiovascular Risk Factor
Choline and Cardiometabolic Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT04764162
- Testing
- Choline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Coronary Artery Disease
Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation
The purpose of this study is to see if reducing the number of hours during which one eats each day will help reduce levels of LDL cholesterol and improve other markers of metabolic and cardiovascular health (i.e.
- Trial name
- TRE x ICR (NCT05014880)
- Testing
- ICR (Intensive Cardiac Rehabilitation), ICR x TRE (Intensive Cardiac Rehabilitation x Time-Restricted Eating)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
Dietary Exposure
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity
In this project, the investigators aim to explore the impact of dietary L-carnitine supplementation on the TMAO production capacity of gut microbiota.
- Trial name
- NCT02838732
- Testing
- L-carnitine supplementation (500 mg per tablet per day, purchased from GNC company)
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypertension
The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration
The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration.
- Trial name
- BRJ_TMAO (NCT05004935)
- Testing
- beetroot juice, nitrate
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Inflammatory Response, Gut Microbiome
Effect of Jing Si Herbal Tea on Inflammation in Patients With Cardiovascular Disease
Jing Si herbal tea includes eight Chinese herbs: such as mugwort leaves, fish needle grass, Ophiopogon japonicus, platycodon, perilla leaves, chrysanthemum, and licorice.
- Conditions
- Inflammatory Response, Gut Microbiome, Life Quality, Trimethylamine N-oxide
- Trial name
- NCT05420987
- Testing
- Jing Si herbal tea liquid packet
- Volunteers
- 100 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Dietary Modification, Cardiovascular Diseases
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota.
- Trial name
- NCT03781011
- Testing
- Vegetarian diet intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiometabolic Risk Factors
Facilitated Vegan Diet on Cardiometabolic Endpoints and Trimethylamine N-oxide
Vegan meal kit delivery offers consumer convenience and has shown benefit in cardiometabolic parameters such as low-density lipoprotein cholesterol (LDL-c) and weight.
- Trial name
- NCT05071196
- Testing
- Facilitated Vegan Diet, Omnivorous Diet
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Inflammatory Marker, Gut Microbiome
The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink
Through empirical research evaluating the effects of "JING SI HERBAL TEA LIQUID PACKETS" and "JING SI HERBAL TANG HENG POWDER DRINK" as adjunctive treatments for various cardiovascular diseases, we aim to provide sufficient…
- Conditions
- Inflammatory Marker, Gut Microbiome, Trimethylamine N-oxide, HbA1c
- Trial name
- NCT06522412
- Testing
- JING SI HERBAL TEA LIQUID PACKETS, JING SI HERBAL TANG HENG POWDER DRINK
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Cardiovascular Risk Factor
Choline Supplementation and Cardiovascular Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT03646175
- Testing
- Choline
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Aortic Stenosis, Heart Failure
TMAO in Patients With Severe Aortic Stenosis
Trimethylamine N-oxide (TMAO) has recently gained increasing scientific interest in the field of cardiovascular disease, including its role in cell protection against osmotic and hydrostatic stress.
- Trial name
- TASTE (NCT04406805)
- Testing
- Measurement of plasma and urine trimethylamine-N-oxide concentration
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw
Infant Neurodevelopment, Nutrition
Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study
This prospective cohort study examines the relationship between maternal methyl-nutrient status during pregnancy and offspring neurodevelopment.
- Conditions
- Infant Neurodevelopment, Nutrition, Methylation, Birth Outcomes
- Trial name
- NCT07568561
- Where
- 2 sites in Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
Hypertension
Theobromine From Cocoa and Cardiovascular Risk Factors
The goal of this clinical trial is to examine whether consumption of dark chocolate affects blood pressure and a cardiovascular risk factor called trimethylamine N-oxide in Thai male participants with hypertension.
- Trial name
- NCT06820944
- Testing
- dark chocolate, white chocolate
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Chiang Mai University
Gestational Diabetes
Association Between Trimethylamine-N-oxide and Gestational Diabetes Mellitus
Background: The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) has been reported as a novel and independent risk factor for the development of cardiovascular and metabolic diseases, but the association with…
- Trial name
- NCT03415295
- Testing
- Plasma TMAO concentration
- Volunteers
- 1,694 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
CKD Stage 3b, CKD Stage 4
The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4
The aim of this study is to investigate effects of sevelamer carbonate on reducing TMAO in stage 3b-4 CKD (pre-dialysis) patients.
- Trial name
- NCT03596749
- Testing
- Sevelamer Carbonate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fan Fan Hou
Mediterranean Diet, Trimethylamine N-oxide
Mediterranean Diet, Trimethylamine N-oxide (TMAO) and Anti-oxidants in Healthy Adults
Trimethylamine N-oxide (TMAO) is a small organic compound naturally present in fish and seefood or generated by the bacterial breakdown of dietary phosphatidylcholine and carnitine-containing foods within the human gut…
- Conditions
- Mediterranean Diet, Trimethylamine N-oxide, Cardiovascular Risk Factor
- Trial name
- TMED (NCT03060811)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy
Trimethylamine-N-oxide Production and Metabolism
The purpose of this study was to understand the production of trimethylamine-N-oxide (TMAO) and its metabolites from dietary precursors found in fish, eggs and beef.
- Trial name
- NCT02558673
- Testing
- TMAO dietary precursors, Control (or active comparator)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cornell University
Trimethylamine-N-oxide, Gut Microbiota
Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) - WineFlora Study
Recent evidence indicates that Trimethylamine-N-oxide (TMAO) is a pro-atherosclerotic, phosphatidylcholine-dependent metabolite of diet and intestinal flora.
- Conditions
- Trimethylamine-N-oxide, Gut Microbiota, Effects of Red Wine, Atherosclerosis
- Trial name
- NCT03232099
- Testing
- Red Wine consumption, Period without alcohol consumption
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo General Hospital
Hidradenitis Suppurativa, Mediterranean Diet
Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)
Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity.
- Conditions
- Hidradenitis Suppurativa, Mediterranean Diet, Body Composition, Vitamin D Deficiency
- Trial name
- NutriHidra (NCT03683238)
- Testing
- Mediterranean Diet
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontitis, Inflammation
Evaluation of Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
Salivary and serum levels of TMAO and TNF-α can distinguish between individuals with periodontitis and periodontally healthy individuals.
- Conditions
- Periodontitis, Inflammation, Trimethylamine N-oxide (TMAO), TNF-alfa
- Trial name
- TMAO (NCT06906510)
- Testing
- Salivary and Serum TMAO Mesurement, Salivary and Serum TNF-α Mesurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University