Clinical trials: True Coronary Bifurcation Lesions
True Coronary Bifurcation Lesions
COmplex BifuRcation Lesions: a Comparison Between the AXXESS Device and Culotte Stenting: an Optical Coherence Tomography (OCT) Study
Treatment of bifurcation lesions with drug-eluting stents (DES) (especially when a double stent technique is used) is associated with a higher risk for stent thrombosis.
- Trial name
- COBRA (NCT01486095)
- Testing
- AXXESS + Biomatrix Biolimus Eluting stent, Culotte technique with Xience V or Xience Prime stents
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, Ischemic Heart Disease
Comparison of PROVISIONal 1-stent Strategy with DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
[The Purpose of the Clinical Study] The purpose of this randomized comparison study is to compare the 1-stent strategy with a drug-eluting balloon and the 2-stent strategy in patients with non-LM coronary true-bifurcation…
- Trial name
- PROVISIONDEB (NCT06002932)
- Testing
- Procedure: planed 2-stent strategy, Procedure: provisional 1-stent plus DEB strategy
- Where
- South Korea
- Volunteers
- 750 people
- Sponsor
- Saint Vincent's Hospital, Korea
Coronary Bifurcation Lesions, Death
Mini-Crush Or Controlled Balloon-Crush For True Coronary Bifurcation Lesions
The mini-crush technique is one of the leading 2-stent techniques frequently applied by interventional cardiologists to treat complex bifurcation lesions.
- Conditions
- Coronary Bifurcation Lesions, Death, Myocardial Infarction (MI), Stent Thrombosis
- Trial name
- NCT06880978
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Disease
European Bifurcation Club Trial - Two-stent Versus One-stent Technique for Large Bifurcation Lesions
This study will examine use of two-stent versus one-stent techniques for patients with large calibre bifurcation lesions including significant side branch disease.
- Trial name
- EBC TWO (NCT01560455)
- Testing
- single stent, two stent
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Sussex County Hospital
Coronary Artery Disease
H-Side Branch Stent, A New Stent for the Treatment of True Bifurcation Lesions
Intervention for coronary bifurcation lesion is about 10~20% of entire percutaneous coronary intervention (PCI). Bifurcation lesion is difficult to be treated and prognosis of PCI at bifurcation lesion has been poorer compared to…
- Trial name
- NCT02037386
- Testing
- H-side branch stent
- Sponsor
- Yonsei University
Coronary Artery Disease (CAD), Coronary Bifurcation Lesion
Stenting Versus Drug Eluting Balloons Only in Treatment of Coronary Bifurcation Lesion (ROBUST Study)
The goal of this clinical trial is to learn immediate and follow up results of percutaneous treatment of coronary bifurcation lesion using drug eluting balloons (DEB) only in patients with chronic coronary syndrome (CCS).
- Conditions
- Coronary Artery Disease (CAD), Coronary Bifurcation Lesion, Coronary Stenting, Drug Eluting Balloon
- Trial name
- ROBUST (NCT07552194)
- Testing
- Balloon Angioplasty with or without drug administration
- Volunteers
- 272 people
- Sponsor
- Avtandil M. Babunashvili
Coronary Artery Disease
Optimal Stenting Strategy For True Bifurcation Lesions
It is unclear which stenting strategy will be optimal for true bifurcation coronary lesions.
- Trial name
- PERFECT (NCT00693251)
- Testing
- Crush technique, provisional T stenting
- Where
- 12 sites in South Korea
- Volunteers
- 420 people
- Sponsor
- Seung-Jung Park
Coronary Disease
"L-Sandwich" Strategy in the True Coronary Bifurcation Lesions
The treatment of coronary bifurcation lesions continue to remain challenges. Due to the complexity of the anatomical structure and the limitations of imaging, there are poor attachment and under-expansion of the stent at the…
- Trial name
- L-Sandwich (NCT04753827)
- Testing
- Drug eluting stent, Durg coated balloon
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease
Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions
This study is designed to investigate whether drug-coated balloon (DCB) compared to conventional balloon angioplasty for side branch after provisional stenting will lead to lower rates of the composite endpoint of major adverse…
- Trial name
- DCB-BIF (NCT04242134)
- Testing
- Drug-coating balloon
- Where
- China
- Volunteers
- 784 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease (non-left Main), Coronary Bifurcation Lesion
The European Bifurcation Club Randomized Trial of Stepwise Provisional Stenting Versus Drug Coated Balloon Therapy for Non-left Main True Coronary Bifurcations
Clinical outcomes are worse in patients with coronary artery bifurcation lesions, even if commonly encountered in clinical practice.
- Trial name
- EBC DCB (NCT06822322)
- Testing
- Percutaneous Coronary Angioplasty, Stepwise Provisional Stent Strategy, Drug Coated Balloon Strategy
- Volunteers
- 750 people
- Sponsor
- Ceric Sàrl
Coronary Heart Disease
Comparison of Double Kissing Culotte Stenting With Double Kissing Crush Stenting for True Bifurcation Lesions
Percutaneous coronary intervention (PCI) for the treatment of coronary bifurcation lesion (BL) remains a challenging task. The DK-crush have been established as a safe and efficacious dual-stenting technique, which can…
- Trial name
- NCT01735656
- Testing
- Resolute stents
- Where
- 12 sites in China
- Volunteers
- 328 people
- Sponsor
- Fujian Medical University
Percutaneous Transluminal Coronary Angioplasty, Coronary Artery Disease
The European Bifurcation Club Left Main Study
The objective of the study is to investigate clinical outcomes following single versus dual stenting strategies for the treatment of true bifurcation distal left main coronary artery lesions.
- Trial name
- EBC MAIN (NCT02497014)
- Testing
- 1 Stent, 2 Stents
- Where
- 24 sites in Denmark, France and 6 more
- Volunteers
- 450 people
- Sponsor
- European Cardiovascular Research Center
Coronary Artery Disease
Comparison of Double-kissing Crush and Double-kissing Culotte Stenting
True bifurcation lesions (TBLs) are not rare clinical conditions and may be associated with adverse cardiovascular outcomes due to their complex anatomy and the variety of interventional therapy.
- Trial name
- NCT04789161
- Testing
- double kissing crush stenting, double kissing culotte stenting
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital