Clinical trials: Tryptophan Metabolism Alterations
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Bruxism, Anxiety State
Evaluation of the Relationship Between Bruxism and Tryptophan Metabolites
Psychological causes are often cited as the most important of the underlying factors for bruxism. However, there are very few studies that can objectively demonstrate this.
- Conditions
- Bruxism, Anxiety State, Tryptophan Metabolism Alterations
- Trial name
- NCT05760482
- Testing
- Metobolites serum level measurement, Anxiety and stress level measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Selcuk University
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Tryptophan Metabolism Alterations, Polymorphism
Effect of Genetic Alterations Affecting the Genes Encoding the Major Enzymes of the Kynurenine Pathway on Suicidal Behavior
Current research has shown that an imbalance in the Kynurenine pathway plays a role in the physiopathology of neurogenerative and mental disorders (with a decrease in neuroprotective metabolites and an increase in neurotoxic…
- Conditions
- Tryptophan Metabolism Alterations, Polymorphism, Suicidal Behavior
- Trial name
- SuiKYN (NCT04565834)
- Testing
- SNP (single nucleotide polymorphism) genotyping
- Where
- 2 sites in France, Spain
- Volunteers
- 849 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes