Clinical trials: Tuberculosis, Lymph Node
Mediastinal Lymph Node Enlargement, Sarcoidosis
Bronchoscopic Sampling Techniques in Sarcoidosis
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal lymph node (MLN) sampling.
- Conditions
- Mediastinal Lymph Node Enlargement, Sarcoidosis, Tuberculosis, Lymphomas
- Trial name
- NCT01836822
- Testing
- EBUS guided transbronchial forceps biopsy (EBUS-TBFB), EBUS guided transbronchial needle aspiration (EBUS-TBNA), large bore (19G) histologic needle biopsy of the mediastinal lymph nodes
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Warsaw
Tuberculosis
Role of EBUS-TBNA in Diagnosing TB in Mediastinal/Hilar Lymph Nodes
This is an observational prospective study. Role of EBUS-TBNA (endobronchial ultrasound transbronchial needle aspiration) is evaluated to diagnose tuberculosis in mediastinal and/or hilar lymph nodes.
- Trial name
- NCT01350674
- Testing
- EBUS-TBNA
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Tuberculous Lymphadenitis, Cervical
Steroids vs Placebo in Treatment of Tuberculous Lymphadenitis
This study will be conducted as a single blinded randomized control trial. The goal of this clinical trial is to learn about the role of low dose steroids in the resolution of tuberculous lymphadenitis.
- Trial name
- NCT06236152
- Testing
- Ferrous sulfate, Deltacortril
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Fahad Javed Awan
Tuberculosis, Mediastinal and Hilar Lymph Node Enlargement
Diagnostic Performance and Safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy in Diagnosing Tuberculous Mediastinal Lymphadenitis: a Randomised Controlled Trial
The goal of this clinical trial is to compare the diagnostic efficacy and safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy (EBUS-TBMC) versus standard EBUS-guided Transbronchial Needle Aspiration…
- Trial name
- NCT07459569
- Testing
- EBUS-TBMC, EBUS-TBNA
- Where
- China
- Volunteers
- 108 people
- Sponsor
- China-Japan Friendship Hospital
Lymphadenitis, Tuberculous, Immune Defect
Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient' Block Paraffins 2019 Until 2021
Mycobacterium tuberculosis (M. tuberculosis) infection is still a problem that cannot be overcome in Indonesia. In 2018 the number of tuberculosis (TB) sufferers in Indonesia reached more than 850/100,000 population, an increase…
- Trial name
- NCT05202548
- Testing
- Immuno-histochemical staining
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Katolik Widya Mandala Surabaya
Tuberculosis, Tuberculosis, Pulmonary
Shortened Regimen for Drug-susceptible TB in Children
While drug-susceptible tuberculosis (TB) disease in children currently requires four to six months of treatment, most children may be able to be cured with a shorter treatment of more powerful drugs.
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Tuberculosis, Lymph Node, Mycobacterium Tuberculosis
- Trial name
- SMILE-TB (NCT06253715)
- Testing
- Isoniazid, Rifampin, Pyrazinamide
- Where
- 9 sites in India, Indonesia and 5 more
- Volunteers
- 860 people
- Sponsor
- Johns Hopkins University
Non-small Cell Lung Cancer
Endobronchial Ultrasound Guided Transbronchial Aspiration (EBUS-TBNA) in Non Small Cell Lung Cancer (NSCLC) in a Tuberculosis-endemic Country
In lung cancer with enlarged or non-enlarged mediastinal lymph nodes, contrast-enhanced computed tomography (CT) and Positron emission tomography (PET) scan frequently show discrepancy in tuberculosis-endemic area.
- Trial name
- NCT01156623
- Testing
- EBUS-TBNA
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Extrapulmonary Tuberculosis
MBLA to Differentiate IRIS From Treatment Failure in Extrapulmonary Tuberculosis
This prospective, multi-center study aims to evaluate the Molecular Bacterial Load Assay (MBLA) on lymph node aspirates as a tool to distinguish between late immune reconstitution inflammatory syndrome (IRIS) and treatment…
- Trial name
- MBLA_IRIS (NCT07778082)
- Testing
- MBLA from routine lymph node aspirate
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Research Center Borstel
Lymphadenopathy, Tuberculosis
Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples
The purpose of this study is to compare the diagnostic efficacy of nested and realtime polymerase chain reaction for Mycobacterium tuberculosis using EBUS-TBNA samples in patients with isolated intrathoracic lymphadenopathy.
- Conditions
- Lymphadenopathy, Tuberculosis, Sarcoidosis
- Trial name
- NCT02497079
- Testing
- Nested PCR for formalin-fixed tissues, Nested PCR for fresh tissues, Real-time PCR for fresh tissues
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Hospital
Tuberculous Lymphadenitis
Applying Shear Wave Elastography for Adjunct Steroid on Tuberculous Lymphadenitis
1. To prospectively collect the radiologic data from the initial phase till the post-treatment phase of tuberculous lymphadenitis. 2.
- Trial name
- NCT05861440
- Testing
- Prednisolone, standard anti-tuberculosis agents
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Mediastinal Lymphadenopathy, Tuberculous Mediastinal Lymphadenopathy
Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)
Although mediastinal tuberculous lymphadenopathy is not rare in adults of such an abnormality. Isolated mediastinal without a parenchymal lung lesion in adults is unusual with the incidence of 0.25%-5.8%.
- Trial name
- NCT01121432
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Lymphadenopathy, Lymphnode Metastasis
Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes
Lymph nodes are one of the most important components of the human immune system, and superficial lymph node enlargement lacks specificity.
- Conditions
- Lymphadenopathy, Lymphnode Metastasis, Lymphoma, Lymphatic Tuberculosis
- Trial name
- NCT07155954
- Testing
- SRUS imaging of the lymph nodes before surgery or biopsy
- Where
- China
- Volunteers
- 779 people
- Sponsor
- Peking University Third Hospital
Lymphadenopathy, Lung Cancer
Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT04743583
- Testing
- Endosonography B-mode examination
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Extrapulmonary Tuberculosis, Lymph Node Tuberculosis
Positron Emission Tomography in Extrapulmonary Tuberculosis
Tuberculosis (TB) remains a major public health problem. In extra-pulmonary forms, evidence of bacteriological cure is difficult to be obtained raising the need for other therapeutic assessment tools.
- Conditions
- Extrapulmonary Tuberculosis, Lymph Node Tuberculosis, Bone Tuberculosis
- Trial name
- TUBOGTEP (NCT01613196)
- Testing
- Positron Emission Tomography with 18F-Fluoro-deoxy-glucose
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris