Clinical trials: Tuberculosis
Tuberculosis
Safety and Immunogenicity of 2 Formulations of Tuberculosis Vaccine GSK692342 Given at 0,1 Months to Healthy Adults
This study will assess the safety and immunogenicity of 2 different formulations of tuberculosis vaccine GSK692342 in healthy adults.
- Trial name
- NCT00397943
- Testing
- GSK's candidate Mycobacterium tuberculosis vaccine 692342, Comparator vaccine with recombinant Mycobacterium tuberculosis antigen and adjuvant system, Comparator vaccine with recombinant Mycobacterium tuberculosis antigen and physiological saline
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tuberculosis
Evaluation of an Enhanced Tuberculosis Infection Control Intervention in Healthcare Facilities in Vietnam and Thailand
Study Design: Stratified, matched, cluster-randomized, controlled trial Unit of Randomization: Healthcare facility Study Duration: 3 years; prevalence of latent Tuberculosis infection (LTBI) in healthcare workers (HCWs) will be…
- Trial name
- EnTIC (NCT02073240)
- Testing
- Enhanced TB IC Package
- Where
- 22 sites in Thailand, Vietnam
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Tuberculosis
Study to Investigate the Safety and Efficacy of GC3107 (BCG Vaccine) in Healthy Adults
Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally.
- Trial name
- NCT03363178
- Testing
- GC3107
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Tuberculosis
Evaluation of the Safety, Tolerability, PK of TBAJ-587 in Healthy Adults
Phase 1, Partially Blinded, Placebo-Controlled, Randomized, Combined Single Ascending Dose with Food Effect Cohort Trial (Part 1) and Multiple Ascending Dose Trial (Part 2) to Evaluate the Safety, Tolerability, and PK of TBAJ-587…
- Trial name
- NCT04890535
- Testing
- TBAJ-587
- Where
- Netherlands
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Tuberculosis (TB)
Safety and Immunogenicity of GSK Biological's Candidate Tuberculosis Vaccine Mtb72F/AS02 in Healthy PPD-negative Adults.
Vaccination against tuberculosis (TB) /healthy PPD-negative adults aged 18 to 45 years.Three doses of primary vaccination followed by a booster dose after completion of primary vaccination course.
- Trial name
- NCT00291889
- Testing
- Mtb72F/AS02.
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tuberculosis, Pulmonary
Post TB Sequelae Study
The goal of this prospective cohort study is to learn about the long-term health effects of tuberculosis (TB) in children, adolescents, and adults who have completed standard TB treatment in Bangladesh.
- Trial name
- NCT06744179
- Testing
- echocardiography, chest x-ray, full blood count , SGPT, lipid profile, HbA1C, AQ20 questionnaire, mmRC dyspnoea scale, Duke activity status index, COPD assessment test, Age and stage questionnaire
- Where
- Bangladesh
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Tuberculosis, Tuberculosis, Pulmonary
A Systemic Screening for TB Disease in High-risk Groups in Barcelona
The purpose of this screening study is to identify and screen vulnerable population in Barcelona for active pulmonary tuberculosis
- Trial name
- SYS-TB-S (NCT06706596)
- Testing
- Screening for TB symptoms, Chest X-ray
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Latent Tuberculosis Infection
Vitamin A Supplementation for Modulation of Mycobacterium Tuberculosis Immune Responses in Latent Tuberculosis
In populations with high prevalence of latent tuberculosis infection (LTBI), malnutrition (PEM) may influence incident rates of TB.
- Trial name
- NCT00558480
- Testing
- Vitamin A
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
HIV, Tuberculosis
A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects
The purpose of this study is to study the safety, tolerability and pharmacokinetics of rifabutin dosing with lopinavir/ritonavir tablets in healthy volunteers.
- Trial name
- NCT00743470
- Testing
- lopinavir/ritonavir, rifabutin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Abbott
Tuberculosis
Safety and Immunogenicity of Nyaditum Resae® Probiotic to Protect From Tuberculosis
This is a double-blind, masked, compared with placebo clinical trial in healthy volunteers with or without tuberculosis infection.
- Trial name
- NCT02076139
- Testing
- Nyaditum resae® 10e4, Nyaditum resae® 10e5, Distilled water
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manresana de Micobacteriologia, SL
Prevention of TB Recurrence
Study to Check the Efficacy and Safety of Recombinant BCG Vaccine in Prevention of TB Recurrence
This is a Phase II/III trial with two groups of adults successfully cured of category 1 pulmonary TB receiving either VPM1002 or placebo.
- Trial name
- NCT03152903
- Testing
- VPM1002 (Recombinant BCG Vaccine)
- Where
- 10 sites in Bangladesh, India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Serum Institute of India Pvt. Ltd.
HIV I Infection, Tuberculosis
Evaluating the Safety and Immunogenicity of MTBVAC
The purpose of this study is to evaluate the safety and immunogenicity of MTBVAC in adolescents and adults living with and without HIV in South Africa
- Trial name
- HVTN605A5421 (NCT05947890)
- Testing
- MTBVAC, BCG
- Where
- 16 sites in South Africa
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
Tuberculosis
Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers
The purpose of this study is to evaluate the bactericidal activity against Mycobacterium tuberculosis of faropenem boosted with amoxicillin/clavulanic acid.
- Trial name
- NCT02393586
- Testing
- Faropenem, Amoxicillin/clavulanic acid 500mg/125mg, Rifampicin
- Where
- Singapore
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Pulmonary Tuberculosis
Phase 1 ID93 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
The purpose of this study is to determine the safety, tolerability, and immunogenicity in healthy adult subjects of an investigational vaccine being developed for the prevention of pulmonary tuberculosis.
- Trial name
- NCT01599897
- Testing
- ID93 + GLA-SE, ID93 alone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
TB Multi-drug Resistant
Epidemiology of MDR-TB in Peru
The purpose of this study is to better understand tuberculosis (TB) and the risk of infection with TB, in Peru. TB is a disease that is caused by bacteria and transmitted through droplets in the air that come from the lungs of an…
- Trial name
- Estudio Epi (NCT00676754)
- Testing
- Statens Serum Institut RT23 2TU tuberculin
- Where
- Peru
- Volunteers
- 18,544 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Tuberculosis
Using BCG Vaccine to Understand Tuberculosis Infection
Tuberculosis (TB) is a disease that usually causes an infection in the lungs. The only vaccine to prevent TB is called BCG (Bacillus Calmette-Guérin).
- Trial name
- Pilot BCG CHIM (NCT05820594)
- Testing
- Intradermal BCG (bacillus calmette-guerin) vaccine AJV
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
TB - Tuberculosis, Household Contact
Introduction of Dispersible 3HP Formulations for TB Preventive Treatment in Children: a Multi-country Evaluation
The WHO has recommended TB preventive therapy (TPT) for children living with HIV (CLHIV) and household contacts of people living with TB, however, the scale-up and implementation of TPT has been sub-optimal globally particularly…
- Conditions
- TB - Tuberculosis, Household Contact, HIV, Children, Only
- Trial name
- NCT06511180
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The Aurum Institute NPC
Allergic Rhinitis, Asthma
Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen
The investigators propose the development of a range of nasal spray challenge models to study the way the nose can respond to different types of nasal challenge that elicit different forms of inflammation.
- Conditions
- Allergic Rhinitis, Asthma, Latent Tuberculosis
- Trial name
- NCT02090374
- Testing
- Poly ICLC, Poly I:C, R848
- Where
- United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Tuberculosis
Quality of Tuberculosis Care in Mumbai, India
The purpose of this study is to evaluate the impact of the Private Provider Interface Agency (PPIA) program on quality of care. The PPIA is a tuberculosis pilot program implemented in the private health sector of Mumbai city…
- Trial name
- NCT02874755
- Testing
- Tuberculosis Program
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- McGill University
Volatile Organic Compounds, Radiography
Tuberculosis Screening in Paraguayan Prisons
Two diagnostic tools for TB screening in high risk groups need additional assessment: the AeoNose™, an 'electronic nose device' for breath sampling, and digital chest X-ray (CXR) with computer aided detection with CAD4TB®…
- Trial name
- Prinose (NCT04407325)
- Testing
- electronic nose device, dig chest Xray with automated readings
- Where
- 2 sites in Paraguay
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center