Clinical trials: Tumor Gastric
Gastric Cancer, Gastroesophageal Junction Cancer
Human Epidermal Growth Factor Receptor 2 (HER2) Advanced Gastric Epidemiology Study in Korea
This study is designed to gather epidemiological data in Korea on HER2 incidence in gastric and gastroesophageal junction cancer as assessed by local laboratories in a real-life setting.
- Trial name
- NCT02538562
- Where
- 14 sites in South Korea
- Volunteers
- 1,695 people
- Sponsor
- Hoffmann-La Roche
Gastric Cancer, Leucine-restricted Diet
Safety and Efficacy of Leucine-Restricted Diet Combined With Neoadjuvant Chemotherapy and Immunotherapy in Gastric Cancer
Consistent with previous literature, the investigators postulate that a leucine-restricted diet is safe and well-tolerated in gastric cancer patients receiving neoadjuvant chemo-immunotherapy.
- Trial name
- LUCENT-GC-02 (NCT07537361)
- Testing
- Leucine-restricted diet
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Qilu Hospital of Shandong University
Gastric Cancer, Adenocarcinoma of Esophagogastric Junction
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach…
- Trial name
- NCT06300879
- Testing
- Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Neoplasms, Gastrointestinal Tract
Lapatinib in Combination With Weekly Paclitaxel in Patients With ErbB2 Amplified Advanced Gastric Cancer
EGF104578 is two-part study (Pilot part/Randomized part).Pilot part is designed to find the optimal (best) doses of lapatinib and paclitaxel when given together,Randomized part is designed to evaluate the overall survival in…
- Trial name
- NCT00486954
- Testing
- Lapatinib, Paclitaxel
- Where
- 17 sites in China, Japan and 2 more
- Volunteers
- 273 people
- Sponsor
- GlaxoSmithKline
Gastric Cancer
Microbiota and Metabolomics of Intestinal Type of Gastric Cancer
Compare with the gastric cavity without cancerous transformation in atrophic gastritis, analyze the microbiota and metabolomics changes in intestinal type of gastric cancer under the background of atrophic gastritis, and explore…
- Trial name
- NCT06079554
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Jilin University
Gastric Cancer, Surgery
Billroth II With Braun Anastomosis After Radical Distal Gastrectomy for Gastric Cancer
The primary aim of this trial is to rigorously evaluate the comparative benefits and potential risks associated with Billroth II reconstruction with Braun anastomosis versus Billroth II reconstruction alone following distal…
- Conditions
- Gastric Cancer, Surgery, Anastomosis, Gastrostomy
- Trial name
- NCT06229197
- Testing
- Billroth II reconstruction, Braun Anastomosis
- Volunteers
- 176 people
- Sponsor
- Sichuan University
Gastric Cancer
Neoadjuvant FOLFIRINOX in the Treatment of Locally Advanced Gastric Cancer
Phase II single-arm study designed to evaluate the efficacy and safety of preoperative chemotherapy with FOLFIRINOX regimen. The investigators will include 27 patients with resectable locally advanced gastric cancer.
- Trial name
- FOLFIRINOX (NCT03825861)
- Testing
- FOLFIRINOX
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Gastric Cancer
Randomized Phase III Trial of Adjuvant Chemotherapy or Chemoradiotherapy in Resectable Gastric Cancer (CRITICS)
The purpose of this study is to evaluate the efficacy and safety of combined chemotherapy and radiotherapy (in comparison to chemotherapy alone) as adjuvant treatment after surgery for gastric cancer.
- Trial name
- NCT00407186
- Testing
- cisplatin+capecitabine, radiotherapy, epirubicin+cisplatin+capecitabine
- Where
- Netherlands
- Volunteers
- 788 people
- Sponsor
- Dutch Colorectal Cancer Group
Laparoscopic Gastrectomy, Laparoscopic Bursectomy
Laparoscopic Total Gastrectomy With Versus Without Bursectomy
Bursectomy is widely performed in open surgery for advanced gastric cancer in East Asia. However laparoscopic D2 radical total gastrectomy with complete bursectomy is difficult and rare performed.
- Conditions
- Laparoscopic Gastrectomy, Laparoscopic Bursectomy, A Left Outside Bursa Omentalis Approach
- Trial name
- NCT03117283
- Testing
- Laparoscopic D2 radical total gastrectomy with bursectomy using a left outside bursa omentalis approach, Laparoscopic D2 radical total gastrectomy without bursectomy
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Gastric Carcinoma
Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer
This clinical trial evaluates the usefulness of various risk assessment tests, including Helicobacter pylori (H. pylori) breath testing, questionnaires, and endoscopies for identifying participants at high risk for stomach…
- Trial name
- NCT06408220
- Testing
- Biopsy, Biospecimen Collection, Breath Test
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Advanced Gastric Carcinoma, CD8+ Tumor Infiltrating Lymphocytes
Study Evaluating Neoadjuvant Immunotherapy Increasing CD8+ Cell Infiltration in Advance Gastric Adenocarcinoma
Focusing on the clinical question of whether patients with advanced gastric cancer can benefit from immunotherapy, this project intends to detect the degree of CD8+ tumor-infiltrating lymphocyte infiltration in patients with…
- Conditions
- Advanced Gastric Carcinoma, CD8+ Tumor Infiltrating Lymphocytes, Neoadjuvant Immunotherapy
- Trial name
- NCT05270824
- Testing
- radical surgery after neoadjuvant immunotherapy, radical surgery after neoadjuvant chemotherapy
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Endometrial Cancer, Esophageal Cancer
ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
This study will investigate the safety and tolerability of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and MAGE-A4 tumor antigen.
- Conditions
- Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer
- Trial name
- NCT04044859
- Testing
- Autologous genetically modified ADP-A2M4CD8 cells alone or in combination with nivolumab every four weeks or pembrolizumab every 6 weeks
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 120 people
- Sponsor
- USWM CT, LLC
Stomach Neoplasms
Density of Neurons in the Stomach and Prognosis of Gastric Adenocarcinoma
Preclinical studies at our institution, based on a genetic mouse model of stomach cancer, strongly suggest that innervation of the stomach wall is deeply involved in tumorigenesis of stomach cancer.
- Trial name
- NCT01821196
- Testing
- biopsy
- Sponsor
- St. Olavs Hospital
Gastric Cancer
Circulating Free DNA Analysis in Gastrointestinal Cancer, Genitourinary Cancer, Rare Cancer
The investigators planned this study to Patients with histologically confirmed metastatic gastrointestinal cancer, genitourinary cancer , rare cancer with treated any anti-cancer therapy : Extra blood sample collection during…
- Trial name
- NCT02067754
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
Gastric Adenocarcinoma, Esophageal Adenocarcinoma
Pilot Study of Perioperative Docetaxel, Oxaliplatin, and 5-Fluorouracil (FLOT) in Gastroesophageal Adenocarcinoma
Gastric or gastroesophageal junction adenocarcinoma is commonly treated with chemotherapy before and after surgery. The chemotherapy regimen used in our institution, called DCF (docetaxel,cisplatic, 5-fluorouracil) is active…
- Trial name
- NCT01932580
- Testing
- FLOT (5-fluorouracil, oxaliplatin, docetaxel)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Gastric Neoplasm
The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study
Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer or premalignant lesions in the stomach.
- Trial name
- NCT02235246
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Advanced Gastric Carcinoma
A Study of Pemetrexed Plus Oxaliplatin as First Line Therapy in Advanced Gastric Carcinoma
Open label single arm phase II study of Pemetrexed plus Oxaliplatin in patients with advanced gastric carcinoma not previously treated with palliative chemotherapy. 43 Patients will be enrolled in this local trial.
- Trial name
- NCT00192088
- Testing
- pemetrexed, oxaliplatin
- Where
- 13 sites in Italy
- Volunteers
- 43 people
- Sponsor
- Eli Lilly and Company
Gastric Cancer
Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer
Standard treatment for patients with early stage gastric cancer consists of perioperative chemotherapy and surgical resection. If radiation therapy is administered in the adjuvant setting, the radiated area is often large and…
- Trial name
- TNT-SHORT (NCT07101666)
- Testing
- Short course radiation therapy, Standard of care neoadjuvant chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Remimazolam Benzenesulfonate on Nenhanced Recovery After Surgery, Possible Molecular Mechanism of Remimazolam Benzenesulfonate
Effect and Mechanism of Remimazolam Benzenesulfonate on Enhanced Recovery After Surgery in Patients Undergoing Radical Gastrectomy for Gastric Cancer
The purpose of this study is to discuss the benzene sulfonic acid red horse azole shimron the occurrence of postoperative complications in patients with gastric cancer radical and its severity, at the same time, comparing the…
- Trial name
- NCT05559151
- Testing
- Remimazolam Benzenesulfonate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhonghua Chen,MD
Esophageal Cancer, Gastric Cancer
Vinorelbine in Unresectable or Metastatic Esophageal and Gastric Adenocarcinoma
The purpose of this study is to collect anti-tumor activity of vinorelbine when given to patients with esophageal or gastric tumors. We will also collect information on the toxicities of vinorelbine in these patients.
- Conditions
- Esophageal Cancer, Gastric Cancer, Stomach Cancer
- Trial name
- NCT00215462
- Testing
- Vinorelbine
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Dana-Farber Cancer Institute
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