Clinical trials: Tumor Markers, Biological
Renal Cell Carcinoma
Novel Prognostic Markers in Renal Cancer
The purpose of this project is to analyze tumour tissue from a group of subjects with renal cell carcinoma, who have been treated at the Royal Marsden Hospital.
- Trial name
- NCT01002937
- Where
- United Kingdom
- Volunteers
- 182 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer, Metastatic Breast Cancer
PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer
This prospective observational study aims to evaluate serum levels of PTEN, a tumor suppressor gene, and organ-specific microRNAs (miRNAs) associated with metastatic patterns in breast cancer.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, miRNAs, PTEN
- Trial name
- PTEN-miR-MBC (NCT07297134)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Atlas University
Leukemia
Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder
RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn about changes that occur in RNA and identify biomarkers related to cancer.
- Trial name
- NCT01511575
- Testing
- RNA analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis
- Volunteers
- 60 people
- Sponsor
- Children's Oncology Group
Recurrent Melanoma, Stage IV Melanoma
Intermittent LGX818 and MEK162 in Treating Patients With Metastatic Melanoma Who Have BRAFV600 Mutations
This phase II trial studies intermittent dosing of BRAF inhibitor LGX818 (encorafenib) and MEK inhibitor MEK 162 (binimetinib) in treating patients with melanoma that has spread to other parts of the body (metastatic) and have a…
- Trial name
- NCT02263898
- Testing
- Raf kinase inhibitor LGX818, binimetinib, laboratory biomarker analysis
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Cancer
Discovery of Microbiome-based Biomarkers for Patients With Cancer Using Metagenomic Approach
Multicentric prospective study with collection of biological samples as part of type II research
- Trial name
- ONCOBIOTICS (NCT04567446)
- Testing
- Stool, Blood sample
- Where
- 9 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Prostate Adenocarcinoma
Molecular PET/MR Imaging in Vivo Validation of Biomarker for Human Prostate Cancer
Primary objective: To correlate the blood/urine metabolomic biomarkers with PET/MR imaging. Secondary objectives: 1. To evaluate the sensitivity and specificity of the PET/MR in diagnosis of prostate cancer. 2.
- Trial name
- PCAPETMR (NCT03451812)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Head and Neck Cancer, Thyroid Cancer
New MRI Biomarkers in Head and Neck Cancers
Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt.
- Trial name
- NCT03483337
- Testing
- MRI examinations
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Molecular Signature for Breast Cancer
The main objective of this study is to evaluate and compare the diagnostic performance of a diagnostic assistance tool for analysis of 5 prognostic and predictive markers of breast cancer (HER2, Ki67 Index, Mitoses, Estrogen…
- Trial name
- MoSi4BCa (NCT05724407)
- Testing
- Diagnostic assistance tool
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adenocarcinoma, Neoplasms
Study Evaluating Biomarkers In Relapsed/Refractory Pediatric Solid Tumors
This is an open label, two-part study of temsirolimus given as a 60-minute intravenous (IV) infusion once weekly to pediatric subjects with advanced solid tumors.
- Trial name
- NCT00106353
- Testing
- Torisel
- Where
- 30 sites in United States, Canada and 5 more
- Volunteers
- 71 people
- Sponsor
- Pfizer
Breast Cancer
Sonographic Visibility of Breast Biopsy Marker Clips Up to 4 Weeks After Placement
The purpose of this study is to determine how long collagen based marker clips remain visible by ultrasound after placement in suspicious breast lesions and if collagen based marker clips can be reliably identified in the…
- Trial name
- NCT00548392
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Fred Hutchinson Cancer Center
Polycystic Ovary Syndrome, Insulin Resistance
Serum Biomarker Levels Improvement in Poly Cystic Ovarian Syndrome: Impact of Metformin Compared to Healthy Controls
The goal of this interventional study is to assess the effect of drug metformin in improving the fertility hormones and reducing the inflammatory hormones in polycystic ovarian syndrome (PCOS) patients.
- Trial name
- NCT06479434
- Testing
- Metformin
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Breast Cancer, Breast Cancer Mortality
Influence of Lifestyle, Inflammatory Biomarkers, and Genetic Factors on Long-term Breast Cancer Prognosis
The MARIEplus study is a prospective cohort of breast cancer patients recruited into the MARIE (Mamma Carcinoma Risk factor InvEstigation) study, a population-based case-control study of breast cancer conducted in two German…
- Conditions
- Breast Cancer, Breast Cancer Mortality, Breast Cancer Survival, Postmenopausal Breast Cancer
- Trial name
- NCT03401034
- Volunteers
- 3,813 people
- Sponsor
- German Cancer Research Center
BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma
Uterine Lavage to Detect Ovarian Cancer Risk
This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations.
- Conditions
- BRCA Hereditary Ovarian Carcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma, Primary Peritoneal High Grade Serous Adenocarcinoma
- Trial name
- NCT07772869
- Testing
- Uterine Lavage, Archive Sample, Survey Administration
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Washington
Colorectal Cancer
Assessment of Septin9 Biomarker for Detection of Colorectal Cancer in Patients With Positive Fecal Immunochemical Test
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States and affects men and women almost equally.
- Trial name
- NCT01574677
- Where
- 2 sites in United States
- Sponsor
- Epigenomics, Inc
Invasive Fungal Infections
Using of Biomarkers and Blood Culture in Early Detection of Systemic Infections
This work aims to: 1. Validate the performance of CRP, and PCT in early differentiating IFI from bacterial bloodstream infections. 2. Compare the results of CRP and PCT with the results of β-D- glucan. 3.
- Trial name
- NCT05737537
- Testing
- procalcitonin ,CRP and 1, 3- β -D- glucan in early diagnosis of invasive infections
- Volunteers
- 90 people
- Sponsor
- Assiut University
Cervical Cancer
Screening and Identification of Biomarkers on Cervical Cancers
Cervical cancer the most frequent neoplasm and the fifth mortality rate of malignancies of the women in the world. It results in about 1,000 women in Taiwan and about 200,000 women worldwide dying of cervical cancer each year.
- Trial name
- NCT00854269
- Testing
- surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer
Esophageal Squamous Cell Cancer Surveillance With Cytosponge
Surveillance and early detection of esophageal squamous cell carcinoma with minimally-invasive Cytosponge™ cell collection device coupled with molecular biomarkers.
- Trial name
- NCT04192695
- Testing
- Cytosponge cell collection device
- Where
- Poland
- Volunteers
- 178 people
- Sponsor
- Centre of Postgraduate Medical Education
Prostate Cancer
Intraoperational Prostate Loge Biopsies (iPROLOGX) After Radical Prostatovesiculectomy
This project is about the detection of occult tumor cells in surgical margins of radical prostatovesiculectomy by analysing the methylation status of Glutathione S-transferase P 1 (GSTP1).
- Trial name
- iPROLOGX (NCT02460861)
- Testing
- biopsies of the prostatic fossa in Magdeburg, RPVE, ETRARP
- Where
- 2 sites in Germany
- Volunteers
- 279 people
- Sponsor
- University of Magdeburg
Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic
Prospective Exploratory Study of a Multiomic Blood Biomarker Panel to Predict Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The goal of this prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months is to identify biomarkers to predict the overall occurrence of chronic…
- Conditions
- Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic, Taxane-induced Peripheral Neuropathy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
- Trial name
- PRECISE1 (NCT07511569)
- Testing
- longitudinal blood sampling and standardized neurological evaluation over 6 months
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier de Bligny
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