Clinical trials: Tumor Markers, Biological
Prostatic Adenocarcinoma
Dose Escalation Using Fiducial Markers in Image Guided Volumetric Modulated Arc Therapy to the Focal Lesion Micro Boost of Localized Prostate Cancer
Gold markers implanted in the prostate are used frequently for position verification of the prostate during external-beam radiotherapy.
- Trial name
- NCT03384199
- Testing
- Dose escalation to prostate focal lesion
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Cancer, Advanced Solid Tumor
StrataPATH™ (Precision Indications for Approved Therapies)
StrataPATH™ is a non-randomized, open-label trial designed to explore efficacy and safety of multiple FDA-approved and commercially available cancer therapies in new, biomarker-guided patient populations.
- Trial name
- StrataPATH (NCT05097599)
- Testing
- lorlatinib, encorafenib + binimetinib, talazoparib
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Strata Oncology
Prostate Cancer
Impact of Yoga As Complementary Therapy in Patients Undergoing Radical Prostatectomy
The researchers hope to learn if yoga complementary therapy would improve health-related quality of life, recovery of urinary continence and erectile function in patients who underwent prostate cancer surgery (i.e.
- Trial name
- NCT02620033
- Testing
- Yoga therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Bladder Cancer
Biomarker Discovery and Application in Bladder Cancer
The investigators' long-term objective is to research and develop innovative new tests which diagnostic laboratories can use to 1) detect methylated DNA targets, 2) tumor specific antigens, and 3) markers of Bacillus…
- Trial name
- NCT00962052
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Triple Negative Breast Neoplasms, Triple Negative Breast Cancer
Triple-negative Breast Cancer: a New Perspective on Biomarkers
A single-institutional cohort to determine the prevalence of new immunohistochemical panel in advanced triple-negative submitted to neoadjuvant chemotherapy and its association with response and survival.
- Trial name
- TNBCbrazil (NCT03539965)
- Where
- Brazil
- Volunteers
- 239 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Advanced Epithelial Ovarian Cancer
Comparison of Weekly Versus Every Three Weeks of Carboplatin Plus Paclitaxel in Patients With Advanced Epithelial Ovarian Cancer
The aim of the current study is to compare weekly versus three-week collective of carboplatin/paclitaxel in advanced epithelial ovarian cancer.
- Trial name
- NCT05963334
- Testing
- Carboplatin/paclitaxel
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Cairo University
Metastatic Melanoma
Multicenter Tissue Registry in Melanoma
The prospective multicenter translational study Tissue Registry in Melanoma (ADOREG/TRIM; CA209-578) aimed to validate the Tumor Mutational Burden (TMB) and the PD-L1 expression (PD-L1) from a pre-therapeutically obtained tumor…
- Trial name
- TRIM (NCT05750511)
- Testing
- molecular tissue analysis
- Where
- 14 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Dermatologic Cooperative Oncology Group
Advanced/Recurrent Ovarian Cancer
A Master Protocol Study to Investigate Biomarker-guided Novel Anticancer Agent(s) as Monotherapy or Combination Therapy in Participants With Advanced/Recurrent Ovarian Cancer
The main purpose of this study is to investigate the safety, tolerability, preliminary efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of biomarker-guided novel anticancer agent(s) as monotherapy or combination therapy…
- Trial name
- NCT07060365
- Testing
- Saruparib
- Where
- Spain
- Sponsor
- AstraZeneca
Kidney Cancer
Studying Biomarkers in Samples From Younger Patients With Wilms Tumor
RATIONALE: Studying samples of blood, tissue, or bone marrow from patients with cancer in the laboratory may help doctors to learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01576198
- Testing
- DNA analysis, nucleic acid amplification, diagnostic laboratory biomarker analysis
- Volunteers
- 2,227 people
- Sponsor
- Children's Oncology Group
Leukemia
Studying Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia Previously Enrolled on Clinical Trial POG-9421
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01035307
- Testing
- gene expression analysis, microarray analysis, proteomic profiling
- Volunteers
- 90 people
- Sponsor
- Children's Oncology Group
Lung Cancer, Pulmonary Neoplasm
Rarecells Molecular Biomarkers for Early Detection of Lung Cancer
Early diagnosis of lung cancer is a public health priority. Additionally, early detection of recurrences after treatment is crucial for optimizing disease management.
- Trial name
- BioMolCTC (NCT06546007)
- Testing
- CTC-DNA
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Rarecells Diagnostics SAS
Pancreatic Cysts, Pancreatic Cancer
The Clinical,Radiologic,Pathologic and Molecular Marker Characteristics of Pancreatic Cysts Study
The aim is to propose and prospectively validate a diagnostic approach and model for prediction of mucinous versus non-mucinous, and malignant versus non-malignant pancreatic cysts using a combination of clinical, radiologic, and…
- Trial name
- PCyst (NCT01202136)
- Where
- 2 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Lymphoma, Nonneoplastic Condition
Biomarkers in Blood and Tissue Samples From Patients With Epstein-Barr Virus-Positive Hodgkin Lymphoma
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01490801
- Testing
- DNA analysis, RNA analysis, cytogenetic analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Lung Cancer, Lung
Establishing a Longitudinal Cohort Study of Lung Cancer Using Tissue and Peripheral Blood Metabolomics.
This study will utilize tissue and peripheral blood samples for metabolomics analysis and establish a longitudinal metabolomics cohort at multiple critical treatment time points to comprehensively investigate the role of…
- Conditions
- Lung Cancer, Lung, Lung Cancer (NSCLC), Metabolomics
- Trial name
- NCT06843707
- Testing
- Monitoring serum metabolites in lung cancer patients using tissue and peripheral blood samples.
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Colorectal Cancer
Serum Endocan Levels in Colorectal Cancer
This case-control study aims to measure serum endocan levels in patients with colorectal cancer and healthy controls using ELISA and to compare the levels between the two groups.
- Trial name
- NCT07842692
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sarcoma
Pharmacometabolomic of Trabectedin in Soft Tissue Patients
This perspective, mono institutional study is addressed to find potential serum and urine biomarkers predictive of the pharmacokinetic and pharmacodynamic profile of soft tissue sarcomas patients treated with trabectedin.
- Trial name
- Metabol-STS (NCT04394728)
- Testing
- Trabectedin
- Volunteers
- 44 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
IPMN, Pancreatic
Integration of Multiomics Markers for Invasive IPMNs Identification Through the Set-up of the INvasive Cyst bIomarkers Detection (INCITE) Consortium
Although intraductal papillary mucinous neoplasms (IPMNs) represent potential precursors of pancreatic cancer, IPMNs with invasive cancer are rare.
- Trial name
- INCITE (NCT06694792)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Lung Adenocarcinoma, Breast Adenocarcinoma
Prognostic Value of the Marker P63 in Adenocarcinoma of Lung, Breast, and Pancreas
The p63 gene is a recently discovered member of the p53 family located at chromosome 3q27Many studies have reported that overexpression of p63 can mimic p53 activities by binding DNA, activating transcription, and inducing…
- Conditions
- Lung Adenocarcinoma, Breast Adenocarcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT01942629
- Testing
- their will be no intervention in any of the groups, the study is retrospective
- Volunteers
- 300 people
- Sponsor
- Rambam Health Care Campus
Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma
Biomarkers in Patients With Advanced Rhabdomyosarcoma
This research trial studies tumor tissue to identify important proteins and biomarkers from patients with rhabdomyosarcoma that has spread to other places in the body and usually cannot be cured or controlled with treatment.
- Conditions
- Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma, Childhood Embryonal Rhabdomyosarcoma, Previously Treated Childhood Rhabdomyosarcoma
- Trial name
- NCT01668095
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
Leukemia
Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01229956
- Testing
- DNA methylation analysis, gene expression analysis, microarray analysis
- Volunteers
- 32 people
- Sponsor
- Children's Oncology Group
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