Clinical trials: Tumor Markers, Biological
Melanoma
Bio-marker Analysis Using Circulating Tumor Cells in Patients With Melanoma
This research trial studies the levels of a type of biomarker, circulating tumor cells (CTCs), in the blood of patients with stage I-IV melanoma.
- Trial name
- NCT02828345
- Testing
- Specimen Collection
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pancreatic Adenocarcinoma, Pancreatic Cancer
The Influence of Secretin Stimulated Pancreatic Secretion on ctDNA Expression in Patients With Pancreatic Ductal Adenocarcinoma: The Role of Biomarkers in Determining the Prognosis of Pancreatic Ductal Adenocarcinoma
The goal of this study is to assess the influence of pancreatic secretion stimulation by intravenously administered secretin on circulating tumor DNA in patients with pancreatic ductal adenocarcinoma.
- Trial name
- NCT06807112
- Testing
- Intravenously administered secretin
- Where
- Czechia
- Volunteers
- 39 people
- Sponsor
- Charles University, Czech Republic
Adult Giant Cell Glioblastoma, Adult Glioblastoma
18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy
The purpose of the study is to conduct research of a new PET radiopharmaceutical in cancer patients. The uptake of the novel radiopharmaceutical 18F-FPPRGD2 will be assessed in study participants with glioblastoma multiforme…
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Male Breast Cancer
- Trial name
- NCT01806675
- Testing
- 18F-fludeoxyglucose (18F-FDG), 18F-FPPRGD2
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sanjiv Sam Gambhir
Premalignant Lesion, Head and Neck Squamous Cell Carcinoma (HNSCC)
A Clinical and Biological Umbrella Protocol for Smoker or Non-smoker Patients With OPML or HNSCC
This is a multicenter minimal risk or burden prospective 3-cohort follow-up and monitoring study that aims to collect clinical, socio-psychological, medico-economics data and biospecimens for patients with oral potentially…
- Trial name
- UMBRELLA (NCT03276819)
- Testing
- Samples collection, Psychological and Sociological evaluation, Intensive and sustained smoking cessation program
- Where
- 10 sites in France
- Volunteers
- 53 people
- Sponsor
- Centre Leon Berard
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prostate Cancer
Valid Biomarkers in Blood to Predict the Response to Therapy in Prostate Cancer Patients
Participants to the study will be assigned to 7 cohorts according to the stage of disease and planned antitumor treatment at time of study entry.
- Trial name
- NCT03408964
- Testing
- biological samples collection and analysis
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Oncology Institute of Southern Switzerland
Breast Cancer, Endocrine Therapy
Real-World Study on CDK4/6 Inhibitors Combined With Endocrine Therapy and Subsequent Treatment in HR+/HER2- MBC.
Exploring the Efficacy and Safety of Different Systemic Treatment Regimens after CDK4/6i Progression in the Real World has significant implications. This study is an observational, real-world study.
- Conditions
- Breast Cancer, Endocrine Therapy, CDK4/6 Inhibitors, Subsequent Treatment
- Trial name
- NCT06033287
- Testing
- Different treatment regimens following progression on CDK4/6 inhibitors.
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Hunan Cancer Hospital
Gynecologic Cancer
PERformance of Multi-Cancer Early-detectIon Based on Various Biomarkers in fEmale Cancers, PERCEIVE-I
This study is a prospective study aimed to develop and validate the performance of combined multi-omitcs assays for early detection of gynecologic cancers.
- Trial name
- NCT04903665
- Testing
- Multi-cancer early detection test
- Where
- China
- Volunteers
- 495 people
- Sponsor
- Fudan University
Lung Adenocarcinoma, Surgery
DNA Methylation Biomarkers to Predict Survival After Surgery for Lung Adenocarcinoma
This study is designed to assess DNA 5-methylcytosine (5mC) methylation modifications in lung adenocarcinoma (LUAD) samples and develop a prognosis-predictive model for LUAD based on cancer tissue DNA 5mC levels.
- Conditions
- Lung Adenocarcinoma, Surgery, Prognostic Cancer Model
- Trial name
- NCT06477211
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Nanjing University
Leukemia
Biomarkers in Samples of Bone Marrow From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01290107
- Testing
- DNA analysis, gene rearrangement analysis, microarray analysis
- Volunteers
- 9 people
- Sponsor
- Children's Oncology Group
Non-melanomatous Skin Cancer, Pancreatic Cancer
Studying a Tumor Marker for Testicular Cancer, Skin Cancer, Small Intestine Cancer, and Pancreatic Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Non-melanomatous Skin Cancer, Pancreatic Cancer, Small Intestine Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00899132
- Testing
- in situ hybridization, protein expression analysis, immunologic technique
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Case Comprehensive Cancer Center
Brain Tumor
Real-time Assessment of Frameless Intrafraction Motion
The purpose of this study is to assess the ability of a modified thermoplastic mask system in keeping an individual head stationary for a predefined amount of time.
- Trial name
- NCT01202539
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
This study aims to investigate the clinical value of small extracellular vesicle (sEV) miRNAs as predictive biomarkers for immunochemotherapy efficacy in extensive-stage small cell lung cancer (ES-SCLC).
- Trial name
- NCT07070011
- Testing
- EC/EP + ICIs
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Chest Hospital of Shanghai Jiao Tong University
Lung Neoplasm, Carcinoma Non-small Cell Lung Cancer Stage IIIA
Phase III Lucanix™ Vaccine Therapy in Advanced Non-small Cell Lung Cancer (NSCLC) Following Front-line Chemotherapy
Rationale: Vaccines made from gene-modified tumor cells may help the body build an immune response to kill tumor cells. It is not yet known whether vaccine therapy is more effective than a placebo as maintenance therapy in…
- Conditions
- Lung Neoplasm, Carcinoma Non-small Cell Lung Cancer Stage IIIA, Carcinoma Non-small Cell Lung Cancer Stage IIIB, Carcinoma Non-small Cell Lung Cancer Stage IV
- Trial name
- STOP (NCT00676507)
- Testing
- Lucanix™
- Where
- 82 sites in United States, Canada and 6 more
- Volunteers
- 532 people
- Sponsor
- NovaRx Corporation
Cancer
A Study of TS-1, Cisplatin (CDDP) and RAD001 (Everolimus)
Hypothesis: The addition of RAD001 to TS-1/CDDP is safe and can improved the efficacy of TS-1/CDDP. The rationale for combining RAD001 with TS-1/CDDP are: 1.
- Trial name
- NCT01096199
- Testing
- TS-ONE, Cisplatin, RAD001
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National University Hospital, Singapore
Hepatocellular Carcinoma
Assessing the Prognosis of TACE in Combination With PD-1/PD-L1 Inhibitors and Molecular Target Therapies for HCC by Using Clinical and Imaging Biomarkers
The purpose of this study is to id transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) and molecular targeted therapies in patients with hepatocellular carcinoma (HCC) .
- Trial name
- CHANCEsub (NCT05278195)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongda Hospital
Non-Small Cell Lung Cancer
Marker Guided Breathhold Radiotherapy in NSCLC
Proof of concept study evaluating safety and performance of a gel marker (BioXmark) used for image guidance in deep inspiration breathhold radiotherapy (DIBH IGRT) in patients with locally advanced non-small cell lung cancer…
- Trial name
- NCT02447900
- Testing
- BioXmark
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steen Riisgaard Mortensen
Colo-rectal Cancer
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in…
- Trial name
- NO-CUT (NCT03565029)
- Testing
- XELOX, Radiotherapy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Pleural Mesothelioma Malignant
Identification of Prognostic and Predictive Biomarkers of Toxicity in Patients With Malignant Pleural Mesothelioma and Treated With High Doses of Radiotherapy (MESORTIBO)
Malignant pleural mesothelioma (MPM) is a tumour that originates from the pleural layers (visceral and parietal) that envelop the lungs and the inner wall of the thoracic cage.
- Trial name
- MESORTIBO (NCT06637345)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
MS (Multiple Sclerosis)
Association Between Peripheral Immune Biomarkers and Functional Performance in Multiple Sclerosis
The aim of this observational study is to investigate whether certain substances in the blood associated with the immune system are linked to the physical and mental abilities of individuals with multiple sclerosis.
- Trial name
- NCT07831239
- Testing
- Peripheral Immune Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Halic University
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