Clinical trials: Tumor Markers, Biological
Hepatocellular Carcinoma
Prospective Cohort Study of Changes in Circulatory MicroRNA of Resected Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer death globally but only 20% are diagnosed in its early stages where curative treatment can be carried out.
- Trial name
- PROSECT (NCT05148572)
- Where
- 6 sites in Singapore
- Volunteers
- 101 people
- Sponsor
- National Cancer Centre, Singapore
Colorectal Cancer
Serum Endocan Levels in Colorectal Cancer
This case-control study aims to measure serum endocan levels in patients with colorectal cancer and healthy controls using ELISA and to compare the levels between the two groups.
- Trial name
- NCT07842692
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Circulating Tumor DNA and Immunophenotyping as Potential Biomarkers With Regional Nodal Irradiation for Breast Cancer
This study will assess how radiation affects the patterns of circulating tumor deoxyribonucleic acid (ctDNA) and immune cells (T cells) during radiation treatment in patients with breast cancer.
- Trial name
- NCT04308720
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- Mayo Clinic
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Endometrial Cancer
Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma
Endometrial cancer (EC) is the most frequent gynecological malignancy but there is currently lack of both non-invasive diagnostic tools and novel markers to stratify patients based on their risk of future recurrence.
- Trial name
- BioEndoCar (NCT03553589)
- Testing
- Blood sampling
- Where
- 5 sites in Netherlands, Poland and 1 more
- Volunteers
- 400 people
- Sponsor
- Andrea Romano
Breast Neoplasms
Identification of Breast Cancer Specific Markers in Patients Compared to Healthy Participants
This is an exploratory research study with the aim of identifying specific cancer biomarkers in various subtypes of breast cancer.
- Trial name
- NCT05054010
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Tethis S.p.A.
Breast Cancer Metastatic, Estrogen Receptor-positive Breast Cancer
Personalised Disease Monitoring in Metastatic Breast Cancer
Patients with metastatic breast cancer may respond well to treatment and metastases can remain stable for several years. Despite personalised medicine being increasingly used for diagnosis and treatment, follow-up still include…
- Trial name
- PDM-MBC (NCT04597580)
- Where
- 7 sites in Sweden, United Kingdom
- Volunteers
- 97 people
- Sponsor
- The Christie NHS Foundation Trust
Cancer of Ovary
Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific Biomarkers in Vaginal Fluids
The purpose of this study is to: 1. Identification and characterization of ovarian carcinoma well-known biomarkers, carcinoma antigen 125 (CA125) and Human epididymis protein 4 (HE4) and other potential biomarkers in vaginal…
- Trial name
- NCT02704650
- Testing
- fluid sample
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Plasma Cell Myeloma
Evaluation of Comprehensive Geriatric Assessment and Laboratory Biomarkers in Elderly Patients With Multiple Myeloma
This study evaluates the association between a comprehensive geriatric assessment and laboratory biomarkers with the side effects of chemotherapy in older patients with multiple myeloma (MM).
- Trial name
- NCT05918185
- Testing
- Biospecimen Collection, Comprehensive Geriatric Assessment, Electronic Health Record Review
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mayo Clinic
Clear-cell Renal Carcinoma, Clear-cell Metastatic Renal Cell Carcinoma
Biomarkers Before and After Nephrectomy of Locally Advanced or Metastatic Renal Cell Carcinoma Treated With Everolimus
Disease and Stage: Metastatic and locally advanced clear cell renal carcinoma An open-label, exploratory, single-arm, multicenter trial.
- Trial name
- NEORAD (NCT01715935)
- Testing
- Everolimus
- Where
- 10 sites in France
- Volunteers
- 25 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Complex Atypical Hyperplasia, Endometrial Cancer
18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy
Purpose: The purpose of this study is to evaluate FFNP PET/MRI's utility for predicting response to Levonorgestrel-releasing Intrauterine Device (LR-IUD) hormonal therapy for Complex Atypical hyperplasia (CAH) and Endometrial…
- Trial name
- NCT05483023
- Testing
- 18F-fluorofuranylnorprogesterone PET / MRI
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Early-stage Breast Cancer, Carbohydrate Engorgement
Breast Cancer Diet Intervention Study
The investigators have already proven that Mitotic Activity Index (MAI)is the most robust measure of proliferation in breast cancer tissue.
- Conditions
- Early-stage Breast Cancer, Carbohydrate Engorgement, Proliferation, Insulin Resistance
- Trial name
- BCDIS (NCT03886389)
- Testing
- PreOP
- Volunteers
- 80 people
- Sponsor
- Helse Stavanger HF
Anemia, Colorectal Neoplasm
IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia
116 eligible patients with confirmed non-metastatic colorectal adenocarcinoma and anemia will be randomized to receive either oral ferrous sulphate (control) or intravenous ferric carboxymaltose (intervention).
- Trial name
- IVICA (NCT01701310)
- Testing
- Ferric carboxymaltose, Ferrous Sulphate
- Where
- 8 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Colorectal Cancer, Colorectal Adenoma
Volatile Markers in Digestive Cancer
The study is aimed to determine the potential of volatile marker testing for identification of gastrointestinal cancers (in particular - colorectal and gastric cancers), the related precancerous lesions in the stomach and colon.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Gastric Cancer, Peptic Ulcer Disease
- Trial name
- VOLGACORE (NCT02332213)
- Testing
- Breath sampling for volatile marker detection, Upper endoscopy with biopsies, Colonoscopy with biopsies or lesion removal when required
- Where
- 2 sites in Latvia, Lithuania
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Prostate Cancer
Green Tea Extract and Prostate Cancer
The purpose of the study is to see if a green tea extract can beneficially alter several markers of cancer risk and progression.
- Trial name
- NCT00676780
- Testing
- Polyphenon E (EGCG)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Nasopharyngeal Carcinoma
Prognostic Utility of the Imaging and Biological Signatures in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) differs from other head and neck malignancies terms of its epidemiology, pathology, and treatment outcome. Although NPC is a radiosensitive tumor, distant recurrence remains a clinical challenge.
- Trial name
- NCT04417985
- Testing
- 18F-FDG PET/CT, MRI
- Volunteers
- 112 people
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer
Metabolic Biomarkers in Thoracic Cancers
The purpose of this research study is to develop a method of using magnetic resonance imaging (MRI) to evaluate lung tumors and other thoracic malignancies.
- Trial name
- NCT02095808
- Testing
- Imaging Biomarkers
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Colorectal Cancer (CRC)
Colon Cancer Liquid Biopsy Investigation of Methylation-based Biomarkers Evaluation Using Delta-HLD (CLIMBED)
CLIMBED (Colon cancer Liquid biopsy Investigation of Methylation-based Biomarkers Evaluation using Delta-HLD) is a non-randomized, observational, cross-sectional clinical validation study designed to assess the performance of…
- Trial name
- CLIMBED (NCT07168876)
- Where
- Argentina
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Epiliquid Holding, Inc
Breast Cancer, Breast Neoplasm Female
Targeting Stress-Driven Inflammatory and Angiogenic Pathways With Brief ACT to Enhance Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer
This clinical trial aims to learn whether a brief psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can improve the effectiveness of neoadjuvant chemotherapy in patients with locally advanced breast…
- Conditions
- Breast Cancer, Breast Neoplasm Female, Locally Advanced Breast Cancer (LABC), Locally Advanced Breast Cancer
- Trial name
- NCT07570368
- Testing
- Brief Acceptance and Commitment Therapy, Standard Counseling, Neoadjuvant Chemotherapy
- Volunteers
- 54 people
- Sponsor
- Universitas Airlangga
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