Clinical trials: Tumor Markers, Biological
Prostate Cancer
Improved Prostate Cancer Diagnosis - Combination of Rapid Prebiopsy Magnetic Resonance Imaging and Biomarkers
This study will enroll 200 men with clinical suspicion of prostate cancer due to higher serum level of PSA than 2.5 ng/ml or abnormal digital rectal examination.
- Trial name
- IMPROD2_0 (NCT02844829)
- Testing
- Prostate MRI
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital
Advanced or Metastatic Solid Tumors
PRISM-NK: Precision-Matched Allogeneic Single- or Dual-Target CAR-NK Cells for Advanced Solid Tumors
This Phase 1/2, open-label, biomarker-guided platform study evaluates the safety, tolerability, and preliminary anti-tumor activity of banked allogeneic donor-derived chimeric antigen receptor natural killer (CAR-NK) cells in…
- Trial name
- PRISM-NK (NCT07510828)
- Testing
- EB-PT-CAR-NK-S, EB-PT-CAR-NK-D, Lymphodepleting chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Biotech
Diffuse Large B Cell Lymphoma
Is Trogocytosis a Predictive Marker of CAR-T Cell Response in Diffuse Large B-cell Lymphoma?
CAR-T cell therapy has improved survival in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL R/R). However, only 65% of patients achieve a complete metabolic response after this treatment.
- Trial name
- CARTROG (NCT06352242)
- Testing
- Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in patients, Flow cytometry analysis to determine the level of trogocytosis by effector immune cells in volunteers
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Non-Small Cell Lung Cancer, Radiation-Induced Cardiac Disease
Biomarker Testing to Predict Radiation-Related Heart Disease in Lung Cancer Patients
The study will measure serum Pro-N-Cadherin and NT-proBNP (pro B-type natriuretic peptide) levels in adults with non-small cell lung cancer receiving hypofractionated radiation therapy and evaluate whether these biomarkers…
- Trial name
- NCT07869329
- Testing
- Serum Pro-N-Cadherin Biomarker Assessment, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Anal Cancer Metastatic, Squamous Cell Carcinoma of the Anus Stage Unspecified
A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab
This is an open-label, phase 1/2, multiple-indication platform study to explore safety, potential predictive immune-related biomarkers, and early efficacy (as measured by objective response rate [ORR; Cohorts 1,2, 4,and 5] and…
- Conditions
- Anal Cancer Metastatic, Squamous Cell Carcinoma of the Anus Stage Unspecified, Pancreatic Cancer Metastatic, Unresectable Pancreatic Carcinoma
- Trial name
- GOBLET (NCT07280377)
- Testing
- Pelareorep, Atezolizumab, Gemcitabine and nab-paclitaxel
- Where
- 15 sites in Germany
- Volunteers
- 122 people
- Sponsor
- Oncolytics Biotech
Breast Neoplasms
Biomarkers Investigation of Neoadjuvant Chemotherapy for Breast Cancer
The BINC-B trial is a diagnostic and interventional study in which various function imaging methods as Magnetic Resonance Imaging (PWI, DWI and DCE-MRI) and will be compared with common imaging methods (mammography and/or…
- Trial name
- BINC-B (NCT03242551)
- Testing
- Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Shenzhen People's Hospital
Neuroblastoma
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01493830
- Testing
- fluorescence in situ hybridization, gene expression analysis, microarray analysis
- Volunteers
- 5 people
- Sponsor
- Children's Oncology Group
Endometrial Cancer
Endometrial Cancer Biomarker Changes Following Exposure to Metformin
The investigators will explore the chemopreventive role of metformin. The purpose of this study is to determine whether, among patients with endometrial cancer, treatment with the currently approved insulin sensitizing drug…
- Trial name
- NCT02042495
- Testing
- Metformin
- Where
- Canada
- Sponsor
- Jewish General Hospital
E-cigarette Use, Vaping
A Trial of Varenicline for E-cigarette Cessation
This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.
- Conditions
- E-cigarette Use, Vaping, Nicotine Dependence
- Trial name
- NCT07040566
- Testing
- Varenicline 1mg BID
- Where
- 2 sites in United States
- Volunteers
- 326 people
- Sponsor
- Yale University
Cancer
To Identify Potential New Urine Marker Panel for Cancer Screening
Polyamines are naturally produced metabolites in our cells. There were some reports suggested the urinary levels of polyamines were altered in patients with different cancers.
- Trial name
- NCT04689802
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer
Anti-Mullerian Hormone (AMH) as Marker of Ovarian Reserve
This is a multicentre, prospective study willing to evaluate AMH levels changes in response to chemotherapy plus GnRHa. In the present study we propose to determine AMH levels in breast cancer patients, aged <40yrs receiving…
- Trial name
- NCT02113553
- Testing
- Triptorelin
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Armando Santoro, MD
Gastric Cancer
As a Second-line Treatment for Metastatic Gastric Adenocarcinoma Patients, the Safety and Effective of Vactosertib Administration in Combination With Paclitaxel+Ramucirumab is Evaluated, and a Phase 2a Clinical Trial to Biomarkers
This clinical trial is to evaluate the efficacy and safety of subjects with metastatic gastric adenocarcinoma or adenocarcinoma of the gastroesophageal junction.
- Trial name
- NCT04656002
- Testing
- Vactosertib
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Phase 2 Study of Lovastatin as Breast Cancer Chemoprevention
The study evaluates if a 6-month course of oral lovastatin at 80 mg/day would decrease abnormal breast duct cytology in women with a high inherited breast cancer risk.
- Trial name
- NCT00285857
- Testing
- Lovastatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Pancreas Adenocarcinoma
Verification of Predictive Biomarkers for Pancreatic Cancer Treatment Using Multicenter Liquid Biopsy
This study is for verification of predictive biomarkers for pancreatic cancer treatment using multi-center liquid biopsy.
- Trial name
- NCT04241367
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- National Cancer Center, Korea
Insulin Resistance, Inflammatory Markers
Effectiveness of Low Level Laser Therapy on Insulin Resistance and Inflammatory Biomarkers
It is an interventional study in which 60 women estimated to enroll according to random allocation and assigned into two groups equal.
- Trial name
- NCT04477109
- Testing
- low level laser in addition to diet recommendations
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gastric Cancer
Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer
<Background> 1. Current status of treatment options in advanced gastric cancer. The cytotoxic chemotherapy, usually fluoropyrimidine + platinum combination regimen is current standard of care.
- Trial name
- NCT03694977
- Testing
- MCS110/PDR001 combination
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Head and Neck Cancer
Exploratory Study of Early Biomarkers Allowing Dynamic Assessment of Response to Treatment in Cancers of the Head and Neck
DART is an exploratory molecular analysis study to assess potential early biomarkers of treatment response in squamous cell carcinoma of the head and neck (HNSCC)
- Trial name
- DART (NCT05644457)
- Testing
- Circulating tumour DNA dynamics
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Leukemia, Lymphoma
Blood Samples to Identify Biomarkers of Busulfan
Specific Aim 1: To determine whether endogenous metabolomics-based biomarkers obtained before IV BU administration can predict IV BU clearance. Specific Aim 2: To characterize IV BU metabolism by metabolomics.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma, Immunodeficiency
- Trial name
- NCT02291965
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy.
- Trial name
- TAILOR RT (NCT03488693)
- Testing
- Radiation, No Radiation
- Where
- 485 sites in United States, Canada
- Volunteers
- 2,138 people
- Sponsor
- Canadian Cancer Trials Group
Breast Cancer, Breast Cancer Survivor
Effects of Supervised Aerobic Exercise on Biomarkers, Physical Function, and Quality of Life in Breast Cancer Survivors
This study evaluates the effects of a 12-week supervised aerobic exercise program in women who have completed primary treatment for early-stage breast cancer and are in remission.
- Conditions
- Breast Cancer, Breast Cancer Survivor, Aerobic Exercise
- Trial name
- NCT07798492
- Testing
- Supervised Aerobic Exercise Program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
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