Clinical trials: Tumor Pancreas
Pancreatic Cancer
Positron Emission Tomography Using [18F]-Labeled Substance P Antagonist Receptor Quantifier in Finding Disease in Patients With Pancreatic Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography (PET) using [18F]-labeled substance P antagonist receptor quantifier, may be effective in finding disease in patients with pancreatic cancer.
- Trial name
- NCT00547612
- Testing
- high performance liquid chromatography, pharmacological study, [18F]-labeled substance P antagonist receptor quantifier
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pancreatic Cancer, Pancreatic Adenocarcinoma
Germline Mutations Associated With Hereditary Pancreatic Cancer in Unselected Patients With Pancreatic Cancer in Mexico
Pancreatic cancer is a highly lethal disease. The cause of pancreatic cancer is multifactorial. However, around 10% of cases are associated with hereditary predisposition.
- Trial name
- NCT05305001
- Testing
- Invitae Multi-Cancer Panel ®
- Where
- Mexico
- Volunteers
- 107 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Pancreatic Cancer
An Extension Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer
This open-label extension study will evaluate the long-term safety and efficacy of oral MNTX in participants with advanced pancreatic cancer (adenocarcinoma) who were previously enrolled in Study SAL-REL-2042 (NCT04083651).
- Trial name
- NCT04151719
- Testing
- Methylnaltrexone bromide (MNTX)
- Sponsor
- Bausch Health Americas, Inc.
Diabetes Mellitus, Type 2, PreDiabetes
Blood Markers of Early Pancreas Cancer
Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an…
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Pancreas Cyst, Chronic Pancreatitis
- Trial name
- NCT03568630
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Bladder Carcinoma, Ureter Carcinoma
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors.
- Conditions
- Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer
- Trial name
- ORACLE (NCT05059444)
- Testing
- Guardant Reveal
- Where
- 57 sites in United States, France and 3 more
- Volunteers
- 2,285 people
- Sponsor
- Guardant Health, Inc.
Pancreatic Neoplasms, Other Solid Tumors
Study of KRAS Neoantigen mRNA Vaccine (ABO2102) in Patients With KRAS -Mutated Solid Tumors
The purpose of this study is to evaluate the safety, immunogenicity, pharmacodynamics, as well as preliminary efficacy of KRAS neoantigen mRNA vaccine (ABO2102) alone and in combination with toripalimab (anti-PD-1 monoclonal…
- Trial name
- NCT06577532
- Testing
- ABO2102, Toripalimab
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Ruijin Hospital
Pancreatic Cancer
Ipilimumab +/- Vaccine Therapy in Treating Patients With Locally Advanced, Unresectable or Metastatic Pancreatic Cancer
Research Hypothesis: Ipilimumab (an antibody that blocks negative signals to T cells) administered alone or in combination with a pancreatic cancer vaccine (allogeneic pancreatic tumor cells transfected with a GM-CSF gene), has…
- Trial name
- NCT00836407
- Testing
- Ipilimumab, Pancreatic Cancer Vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Familial Pancreatic Cancer, Familial Pancreatic Carcinoma
A Liquid Biopsy for Pancreatic Cancer Early-detection and Disease Monitoring
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an asymptomatic early phase, late diagnosis, and poor survival, particularly in individuals who develop disease outside the context of…
- Conditions
- Familial Pancreatic Cancer, Familial Pancreatic Carcinoma, Hereditary Pancreatic Cancer, Hereditary Pancreatitis
- Trial name
- PANXEON (NCT07700992)
- Testing
- PANXEON
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Università Vita-Salute San Raffaele
Pancreatic Cancer
Study of Respiratory Gated Proton Beam Radiotherapy for Inoperable Pancreas Carcinoma
The only curative option for pancreatic cancer patients is surgery, but the patients within 20% of them are possible for a radical surgery.
- Trial name
- NCT00658801
- Testing
- Respiratory gated proton beam radiotherapy
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- National Cancer Center, Korea
Liver Cancer, Pancreas Cancer
PRIORITY-CONNECT 2 Pilot Trial
The provision of preoperative interventions (prehabilitation: including exercise, nutrition, and psychological treatment) have been reported to reduce postoperative complications by as much as 50% and reduce hospital stay by up…
- Conditions
- Liver Cancer, Pancreas Cancer, Oesophageal Cancer, Gastric Cancer
- Trial name
- NCT06212700
- Testing
- Preoperative Exercise, Postoperative Exercise, Preoperative Nutrition
- Where
- 2 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Pancreas Adenocarcinoma
PRECISE: Pancreatic Cancer and Exercise
The purpose of this study is to establish the feasibility of delivering a prescribed, individualised supervised aerobic and resistance exercise programme during adjuvant therapy, to improve survival and reduce symptom burden in…
- Trial name
- NCT04305067
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Queen's University, Belfast
Colorectal Cancer (CRC) and Pancreatic Cancer (PaCa)
Allocating Resources for Cancer Care in Times of the Sars-CoV-2 Outbreak. Health Care Research
The focus on treatment of COVID19 patients during the Sars-CoV-2 outbreak has most likely implications for the extent and quality of diagnosis and treatment of non-COVID19 patients.
- Trial name
- NCT05479292
- Testing
- Sars-CoV-2 outbreak
- Where
- Germany
- Volunteers
- 6,500 people
- Sponsor
- Technische Universität Dresden
Resectable Pancreatic Ductal Adenocarcinoma
A Phase II Study of Neoadjuvant FOLFIRINOX
The primary objective of this study is to evaluate the rate of pathologic complete response to neoadjuvant FOLFIRINOX in patients with resectable pancreatic cancer using a tissue collection component.
- Trial name
- NCT02178709
- Testing
- FOLFIRINOX
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Indiana University
Pancreatic Cancer
Evaluation of Survival Prognostic Factors for Patients With Exocrine Pancreatic Cancer Resectable or Potentially Resectable
This study aims to collect clinical, biological and quality of life data from patients with a borderline or resectable pancreatic cancer.
- Trial name
- Pancreas-CGE (NCT02818907)
- Testing
- Additional biological samples
- Where
- 8 sites in France
- Volunteers
- 290 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pancreatic Neoplasms
Larotaxel Compared To Continuous Administration of 5-FU in Advanced Pancreatic Cancer Patients Previously Treated With A Gemcitabine-Containing Regimen
The purpose of this study is to compare the efficacy and the safety Larotaxel administered as single agent every 3 weeks to continuous administration of 5-FU every 3 weeks, in patients with advanced pancreatic cancer (non…
- Trial name
- PAPRIKA (NCT00417209)
- Testing
- Larotaxel (XRP9881), 5-Fluorouracil, Capecitabine
- Where
- 21 sites in United States, Belgium and 19 more
- Volunteers
- 408 people
- Sponsor
- Sanofi
Pancreatic Cysts, Pancreatic Cancer
The Clinical,Radiologic,Pathologic and Molecular Marker Characteristics of Pancreatic Cysts Study
The aim is to propose and prospectively validate a diagnostic approach and model for prediction of mucinous versus non-mucinous, and malignant versus non-malignant pancreatic cysts using a combination of clinical, radiologic, and…
- Trial name
- PCyst (NCT01202136)
- Where
- 2 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Resectable Pancreatic Cancer
Study of Gemcitabine and Abraxane to Treat Potentially Operable Pancreatic Cancer
The main purpose of this research study is to evaluate whether Abraxane and gemcitabine are effective in treating patients with operable pancreatic cancer.
- Trial name
- NCT01298011
- Testing
- Gemcitabine and Abraxane
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Pancreatic Cancer Research Team
Breast Cancer, Pancreatic Cancer
Second Opinions in Oncology
The long-time goal is to understand what decision-making process and patient characteristics factor into a patient deciding to stay with their initial physician versus seeking treatment with a second opinion.
- Conditions
- Breast Cancer, Pancreatic Cancer, Colorectal Cancer
- Trial name
- NCT05102500
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Colorado, Denver
Pancreatic Cancer
Predicting Pancreatic Fistula After Pancreatic Surgery Using Preoperative Immunity
The goal of this observational study is to develop and validate a preoperative immunological signature for predicting postoperative pancreatic fistula (POPF) in adult patients undergoing pancreatic surgery for pancreatic cancer.
- Trial name
- NCT07827911
- Testing
- blood sampling
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Paoli-Calmettes
Colorectal Cancer, Pancreatic Cancer
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT02584244
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Lumicell, Inc.
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